Fig. 1

Cumulative incidence of type 2 diabetes across co-exposure to elevated inflammation and adiposity and their relative risks of contributions to incident type 2 diabetes. For the analysis of the supra-additive effect, the baseline category was defined as having no exposure to adiposity or elevated inflammation. A and B display the results when adiposity was indicated by BMI. C and D display the results when adiposity was indicated by waist circumference. E and F display the results when adiposity was indicated by fatty liver status. In the RERI analysis, all models were adjusted for age, sex, education, smoking status, drinking status, physical activity, family history of diabetes, anti-hypertensives, lipid-lowering drugs, log(TG/HDL-C) (continuous), and SBP (continuous). RERI, relative excess risk due to interaction; others as Table 1