Table 2 MR estimates for the causal associations of birthweight with MI and AF
Exposure | Method | No. of SNPs or outliers | F-statistic | OR (95% CI)a | P value |
|---|---|---|---|---|---|
Association between lower birthweight and MI | |||||
 Birthweight | IVW | 121 | 52 | 1.40 (1.22–1.60) | 2.31E−06 |
MR Egger | 1.17 (0.84–1.61) | 3.53E−01 | |||
Simple mode | 1.34 (0.98–1.83) | 6.62E−02 | |||
Weighted median | 1.27 (1.13–1.43) | 8.60E−05 | |||
Weighted mode | 1.22 (1.03–1.44) | 2.46E−02 | |||
MR-PRESSO | 7 | 1.30 (1.17–1.43) | 1.16E−06 | ||
 Fetal-specific birthweight | IVW | 50 | 33 | 1.31 (1.13–1.51) | 3.12E−04 |
MR Egger | 1.25 (0.84–1.85) | 2.72E−01 | |||
Simple mode | 1.35 (0.99–1.85) | 6.43E−02 | |||
Weighted median | 1.30 (1.12–1.52) | 7.62E−04 | |||
Weighted mode | 1.30 (1.05–1.61) | 1.89E−02 | |||
MR-PRESSO | 3 | 1.34 (1.19–1.51) | 1.82E−05 | ||
 Maternal-specific birthweight | IVW | 29 | 32 | 1.44 (1.10–1.88) | 7.42E−03 |
MR Egger | 1.24 (0.52–2.95) | 6.36E−01 | |||
Simple mode | 1.34 (0.92–1.95) | 1.38E−01 | |||
Weighted median | 1.22 (1.01–1.48) | 3.63E−02 | |||
Weighted mode | 1.37 (0.94–1.99) | 1.16E−01 | |||
MR-PRESSO | 4 | 1.36 (1.16–1.59) | 8.81E−04 | ||
Association between higher birthweight and AF | |||||
 Birthweight | IVW | 123 | 52 | 1.29 (1.16–1.44) | 4.50E−06 |
MR Egger | 1.48 (1.15–1.91) | 3.16E−03 | |||
Simple mode | 1.29 (1.01–1.63) | 4.30E−02 | |||
Weighted median | 1.29 (1.16–1.44) | 5.18E−06 | |||
Weighted mode | 1.24 (1.06–1.45) | 7.57E−03 | |||
MR-PRESSO | 5 | 1.27 (1.15–1.40) | 2.65E−06 | ||
 Fetal-specific birthweight | IVW | 51 | 33 | 1.18 (1.02–1.36) | 2.31E−02 |
MR Egger | 1.48 (1.01–2.17) | 5.05E−02 | |||
Simple mode | 1.23 (0.96–1.59) | 1.06E−01 | |||
Weighted median | 1.28 (1.12–1.47) | 3.52E−04 | |||
Weighted mode | 1.25 (1.03–1.50) | 2.48E−02 | |||
MR-PRESSO | 3 | 1.22 (1.09–1.37) | 1.58E−03 | ||
 Maternal-specific birthweight | IVW | 29 | 32 | 1.13 (0.96–1.32) | 1.31E−01 |
MR Egger | 1.37 (0.85–2.21) | 2.11E−01 | |||
Simple mode | 1.37 (1.02–1.86) | 4.91E−02 | |||
Weighted median | 1.07 (0.92–1.25) | 3.78E−01 | |||
Weighted mode | 1.02 (0.80–1.29) | 8.95E−01 | |||
MR-PRESSO | 2 | 1.12 (0.99–1.27) | 8.90E−02 | ||