Skip to main content

Table 1 GWAS data sources of MR study

From: Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study

Phenotype

PMID or GWAS ID

Sample size (overall or case/control)

Ancestry

Unit

Consortium or cohort study

Exposure

     

 Birthweight

31043758

298,142

European

1-SD (about 500 g)

EGG

Outcome

 MI

33532862

61,000/577,000

European

Event

CARDIoGRAMplusC4D and UK Biobank

 AF

30061737

60,620/970,216

European

Event

HUNT, deCODE, MGI, DiscovEHR, UK Biobank, and AFGen Consortium

Candidate mediator

Socioeconomic indicators (n = 4)

 Education

30038396

1,131,881

European

1-SD

SSGAC

 Household income

29846171

397,751

European

1-SD

UK Biobank

 Occupational attainment

34613391

248,847

European

1-point in skill levela

 Townsend deprivation index

29846171

462,464

European

1-SD

Psychological well-being indicators (n=4)

 Positive affect

30643256

410,603

European

Z score

Meta

 Life satisfaction

30643256

80,852

European

Z score

 Neuroticism

30643256

582,989

European

Z score

 Depressive symptoms

30643256

1,295,946

European

Z score

Lifestyle behaviours (n=7)

 Cigarettes smoked per day

30643251

337,334

European

1-SD

GSCAN

 Alcoholic drinks per week

30643251

335,394

European

1-SD

 Coffee consumption

31046077

375,833

European

1% change

UK Biobank

 Long sleep (≥9 h per night)

30846698

34,184/305,742

European

log-transformed odds

 Short sleep (<7 h per night)

30846698

106,192/305,742

European

log-transformed odds

 Chronotype

29846171

413,343

European

1-SD

 MPA (device-measured)

29899525

91,084

European

1-SD

Body composition and strength (n=7)

 Childhood obesity

22484627

5,530/8,318

European

log-transformed odds

EGG

 BMI

25673413

322,154

European

1-SD

GIANT

 WC

25673412

210,088

European

1-SD

 WHR

25673412

210,088

European

1-SD

 Height

25282103

253,288

European

1-SD

 Appendicular lean mass

33097823

450,243

European

1-SD

UK Biobank

 Grip strength

29846171

461,026

European

1-SD

Cardiometabolic traits (n = 30)

Blood pressure

 Hypertension

29846171

42,857/162,837

European

log-transformed odds

FinnGen

 SBP

30224653

757,601

European

1 mmHg

ICBP

 DBP

30224653

757,601

European

1 mmHg

Glucose metabolism

 Type 2 diabetes

30054458

62,892/596,424

European

log-transformed odds

DIAGRAM, GERA, and UK Biobank

 Fasting glucose

34059833

200,622

European

mmol/L

MAGIC

 2-h glucose

34059833

63,396

European

log-transformed mmol/L

 HbA1c

34059833

146,806

European

%

 Fasting insulin

34059833

151,013

European

log-transformed pmol/L

Lipid and lipoprotein

 Total cholesterol

24097068

188,577

Mixed

1-SD

GLGC

 HDL-C

24097068

188,577

Mixed

1-SD

 LDL-C

24097068

188,577

Mixed

1-SD

 Triglycerides

24097068

188,577

Mixed

1-SD

 ApoA-I

27005778

24,925

European

1-SD

Meta

 ApoB

27005778

24,925

European

1-SD

Metabolites

 Omega-3 fatty acids

met-d-Omega_3

114,999

European

1-SD

UK Biobank

 Omega-6 fatty acids

met-d-Omega_6

114,999

European

1-SD

 DHA

met-d-DHA

114,999

European

1-SD

 Linoleic acid

met-d-LA

114,999

European

1-SD

 Isoleucine

met-d-Ile

115,075

European

1-SD

 Leucine

met-d-Leu

115,074

European

1-SD

 Valine

met-d-Val

115,048

European

1-SD

 Phenylalanine

met-d-Phe

115,025

European

1-SD

 Tyrosine

met-d-Tyr

115,075

European

1-SD

 Alanine

met-d-Ala

115,074

European

1-SD

 Glutamine

met-d-Gln

114,750

European

1-SD

 Glycine

met-d-Gly

114,972

European

1-SD

Kidney function

 CKD

31152163

41,395/439,303

European

log-transformed odds

CKDGen

 eGFR

31152163

567,460

European

1-SD

 UACR

31511532

547,361

European

1-SD

Inflammation marker

 CRP

35459240

575,531

European

1-SD

Meta

  1. aOccupational attainment was recoded as numeric ordinal variables ranging from one to nine with higher values reflecting greater and more complex occupational attainment
  2. AF atrial fibrillation, AFGen atrial Fibrillation Genetics, ApoA-I Apolipoprotein A-I, ApoB Apolipoprotein B, BMI body mass index, CARDIoGRAMplusC4D  Coronary ARtery Disease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics, CKD  Chronic kidney disease, CKDGen  CKD Genetics, CRP  C-reactive protein, DBP  diastolic blood pressure, DHA  docosahexaenoic acid, DIAGRAM  DIAbetes Genetics Replication and Meta-analysis, eGFR  estimated glomerular filtration rate, EGG  Early Growth Genetics; eMERGE  Electronic Medical Records and Genomics, GIANT  Genetic Investigation of ANthropometric Traits, GLGC  Global Lipids Genetics Consortium, GWAS  genome-wide association study, HbA1c  Glycated hemoglobin, HDL-C  high-density lipoprotein cholesterol, HUNT  Nord-Trøndelag Health Study, ICBP  International Consortium of Blood Pressure, LDL-C  low-density lipoprotein cholesterol, MAGIC  Meta-Analyses of Glucose and Insulin-related traits Consortium, MGI  Michigan Genomics Initiative, MR  Mendelian randomization, SBP  systolic blood pressure, SD  standard deviation, SSGAC  Social Science Genetic Association Consortium, WC  Waist circumference; WHR waist-to-hip ratio, UACR  urinary albumin-to-creatinine ratio
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840