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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study

Fig. 3

Mediating role of each mediator in the causal associations of birthweight with MI and AF. Two-step MR was used to evaluate the mediating role of each mediator in the causal associations of birthweight with MI (A) and AF (B). Left: UVMR estimates for the causal effect of birthweight on each mediator. Middle: MVMR estimates for the causal effect of each mediator on MI or AF with adjustment for birthweight. Right: mediation proportion of each mediator in the causal association between birthweight and MI or AF. Negative mediation proportions were truncated at a lower limit of 0%, as it is the lowest threshold to determine a mediation proportion. AF  atrial fibrillation, ApoB  Apolipoprotein B, BMI  body mass index, CI  confidence interval, HbA1c  Glycated hemoglobin, LDL-C  low-density lipoprotein cholesterol, MI  myocardial infarction, MVMR  multivariable Mendelian randomization, SBP  systolic blood pressure, UVMR  univariable Mendelian randomization, WC  Waist circumference

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Cardiovascular Diabetology

ISSN: 1475-2840