Skip to main content
Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study

Fig. 1

Overview of the MR study design.  This MR study consisted of two analysis phases. In Phase 1, the causal associations of birthweight with MI and AF were estimated using UVMR, and the MR estimates showed that birthweight had opposite effects on MI and AF. In Phase 2, two-step MR was applied to screen for 52 candidate mediators that may lie in the pathways between birthweight and MI or AF and quantify the mediation proportions for qualified mediators.  AF  atrial fibrillation, EGG  Early Growth Genetics, IV  instrumental variable; MR  Mendelian randomization; MI  myocardial infarction, MVMR  multivariable Mendelian randomization, UVMR  univariable Mendelian randomization

Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840