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Table 3 Risk of VTE according to HbA1c in patients with CVD

From: Association between glycemic control and risk of venous thromboembolism in diabetic patients: a nested case–control study

Characteristics

Number of cases (%)

Number of controls (%)

Unadjusted ORs

(95% CI)

Adjusted ORs*

(95% CI)

CVD and risk of VTE

 ≤ 6.5%

670 (33.0)

2998 (37.9)

0.99 (0.87–1.13)

1.01 (0.89–1.15)

 > 6.5–7.0%

352 (17.3)

1524 (19.3)

1 (reference)

1 (reference)

 > 7.0–7.5%

307 (15.1)

1142 (14.4)

1.19 (1.02–1.39)

1.14 (0.97–1.34)

 > 7.5–8.0%

163 (8.0)

610 (7.7)

1.18 (0.98–1.43)

1.13 (0.93–1.38)

 > 8.0–9.0%

193 (9.5)

568 (7.2)

1.49 (1.24–1.78)

1.39 (1.16–1.68)

 > 9.0%

201 (9.9)

624 (7.9)

1.47 (1.22–1.77)

1.16 (0.95–1.42)

 No Recording

147 (7.2)

450 (5.7)

1.55 (1.25–1.94)

1.56 (1.24–1.96)

HbA1c-Values (last measurement before the index date) and risk of VTE in women

 ≤ 6.5%

377 (34.4)

1689 (39.2)

1.04 (0.87–1.23)

1.07 (0.90–1.28)

 > 6.5–7.0%

177 (16.2)

818 (19.0)

1 (reference)

1 (reference)

 > 7.0–7.5%

166 (15.2)

618 (14.4)

1.29 (1.04–1.59)

1.21 (0.96–1.51)

 > 7.5–8.0%

87 (7.9)

317 (7.4)

1.30 (1.00–1.69)

1.26 (0.95–1.66)

 > 8.0–9.0%

93 (8.5)

285 (6.6)

1.39 (1.08–1.80)

1.30 (0.99–1.70)

 > 9.0%

107 (9.8)

318 (7.4)

1.64 (1.28–2.12)

1.27 (0.97–1.68)

 No Recording

89 (8.1)

260 (6.0)

1.80 (1.35–2.41)

1.83 (1.35–2.46)

HbA1c-Values (last measurement before the index date) and risk of VTE in men

 ≤ 6.5%

293 (31.3)

1309 (36.3)

0.94 (0.78–1.14)

0.94 (0.78–1.13)

 > 6.5–7.0%

175 (18.7)

706 (19.6)

1 (reference)

1 (reference)

 > 7.0–7.5%

141 (15.1)

524 (14.5)

1.09 (0.87–1.37)

1.06 (0.84–1.34)

 > 7.5–8.0%

76 (8.1)

293 (8.1)

1.07 (0.82–1.41)

0.98 (0.74–1.31)

 > 8.0–9.0%

100 (10.7)

283 (7.8)

1.59 (1.23–2.05)

1.50 (1.15–1.96)

 > 9.0%

94 (10.0)

306 (8.5)

1.30 (0.99–1.72)

1.06 (0.79–1.41)

 No Recording

58 (6.2)

190 (5.3)

1.26 (0.90–1.78)

1.26 (0.88–1.81)

  1. *Adjusted for BMI (categorical), smoking (categorical), CHF, IHD, MI, stroke, hypertension, osteoarthritis, and use of insulin, bisphosphonate, systemic corticosteroids, low-dose acetylsalicylic acid, current and past use of metformin, and current and past use of sulfonylureas