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Table 3 Association between SFRP5 serum concentrations and prediabetes/type 2 diabetes

From: Inverse associations between serum levels of secreted frizzled-related protein-5 (SFRP5) and multiple cardiometabolic risk factors: KORA F4 study

Group

n

SFRP5 levels (ng/ml)

Model 1

Model 2

Model 3

Model 4

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Normal glucose tolerance

430

55.9 (42.6, 69.6)

1

1

1

1

Prediabetes/type 2 diabetes

666

48.8 (35.5, 65.7)***

0.60 (0.50; 0.73)***

0.60 (0.50; 0.73)***

0.75 (0.61; 0.91)**

0.72 (0.58; 0.89)**

  1. The prediabetes/type 2 diabetes group comprised all individuals with impaired fasting glucose and/or impaired glucose tolerance or with newly diagnosed or known type 2 diabetes. SFRP5 levels are given as median (25th; 75th percentiles) and were log2-transformed for the logistic regression analysis, so that OR (95% CI) refer to a doubling in SFRP5 levels
  2. Model 1 adjusted for age, sex, Model 2 model 1 + physical activity, smoking, alcohol consumption, Model 3 model 2 + BMI, Model 4 model 3 + HDL cholesterol, LDL cholesterol, triglycerides, lipid-lowering medication, hypertension, history of myocardial infarction, estimated glomerular filtration rate
  3. ** P < 0.01, *** P < 0.001
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Cardiovascular Diabetology

ISSN: 1475-2840