Fig. 8

Linagliptin inhibits ultrastructural abnormalities in WD-fed hearts. Panels A, D and G depict the normal organized appearance of sarcomeres (S) alternating with a row of intermyofibrillar mitochondria (Mt). WD induces abnormal remodeling of mitochondria and sarcomeres as depicted in Panels B, E and H. Inset in panel E shows Mt swelling and loss of cristae structure. Linagliptin prevented these WD-induced ultrastructural abnormalities (Panels C, F and I). Panels A–C ×800: scale bar 2 μm. Panels B–I ×2000; scale bar 0.5 or 1 μm