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Table 2 Risk of incident type 2 diabetes mellitus (T2DM) by quartiles of TyG and TyG-D

From: Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

P trend

TyG

 Range

<8.16

8.16 to 8.47

8.48 to 8.81

≥8.82

 

 No. of cases

18

35

52

88

 

 No. of person-years

8740.50

8526.83

8529.25

8399.50

 

 Incidence ratea

2.06

4.10

6.10

10.48

<0.001

 Unadjusted model

1 (ref)

2.36 (1.33–4.16)

3.58 (2.09–6.12)

6.30 (3.78–10.50)

<0.001

 Multivariable adjusted model 1b

1 (ref)

2.38 (1.17–4.85)

3.71 (1.89–7.29)

5.54 (2.87–10.71)

<0.001

 Multivariable adjusted model 2c

1 (ref)

2.49 (1.22–5.08)

3.89 (1.98–7.65)

5.69 (2.94–11.01)

<0.001

 Multivariable adjusted model 3d

1 (ref)

2.48 (1.20–5.11)

3.77 (1.83–7.79)

5.30 (2.21–12.71)

<0.001

TyG-D

 Range

<−0.27

−0.27 to 0

0.01 to 0.31

≥0.32

 

 No. of cases

41

39

30

83

 

 No. of person-years

8520.00

9747.08

7373.00

8556.00

 

 Incidence ratea

4.81

4.00

4.07

9.70

<0.001

 Unadjusted model

1 (ref)

0.95 (0.58–1.55)

1.15 (0.68–1.93)

2.19 (1.41–3.39)

<0.001

 Multivariable adjusted model 1b

1 (ref)

0.92 (0.52–1.63)

1.09 (0.59–2.03)

2.51 (1.50–4.19)

<0.001

 Multivariable adjusted model 2c

1 (ref)

0.92 (0.52–1.64)

1.10 (0.59–2.05)

2.52 (1.51–4.22)

<0.001

 Multivariable adjusted model 3d

1 (ref)

1.14 (0.63–2.09)

1.54 (0.80–2.99)

3.91 (2.22–6.87)

<0.001

  1. Data are hazard ratios (HRs) and 95% confidence intervals (95% CIs)
  2. TyG triglyceride glucose index, TyG-D difference in TyG value at the end of follow-up minus that at baseline
  3. aPer 1000 person-years
  4. bAdjusted for gender, age, family history of diabetes and WC
  5. cAdjusted for variables in b as well as education level, marital status, smoking, alcohol consumption and physical activity
  6. dAdjusted for variables in c as well as SBP, DBP and TC, HDL-C and LDL-C levels