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Table 4 Odds ratios for the presence of carotid plaques by urinary NAG and urinary ACR in participants without history of coronary artery disease or ischemic stroke (N = 232)

From: The renal tubular damage marker urinary N-acetyl-β-d-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes

 

ORs (95% CI)

Urinary NAG (0 = at or below mediana, 1 = above median)

Urinary ACR (0 = normoalbuminuriab, 1 = micro- or macroalbuminuriac)

Model 1

1.96 (1.12–3.41)

2.33 (0.97–5.63)

Model 2

1.88 (1.05–3.36)

3.42 (1.20–9.77)

Model 3

2.03 (1.12–3.68)

3.58 (1.25–10.3)

  1. Presence of carotid plaques was defined as the existence of one or more carotid plaques
  2. Model 1: unadjusted
  3. Model 2: adjusted for age (< or ≥40 years), sex, and history of hypertension
  4. Model 3: adjusted for age (< or ≥40 years), sex, history of hypertension, use of lipid-lowering drugs, and eGFR CKD-EPI (< or ≥60 ml/min/1.73 m2)
  5. NAG N-acetyl-β-d-glucosaminidase, ACR albumin-to-creatinine ratio, ORs odds ratios, eGFR estimated glomerular filtration rate, CKD-EPI chronic kidney disease epidemiology collaboration
  6. Bolditalics denotes statistical significance at p < 0.05
  7. aMedian of NAG = 7.21 U/g creatinine, b ACR < 30 mg/g creatinine, c ACR ≥ 30 mg/g creatinine
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Cardiovascular Diabetology

ISSN: 1475-2840