Parameter | Pre-treatment | Post-treatment | ||||||
---|---|---|---|---|---|---|---|---|
CkC (9) | DbC (6) | DbE (6) | P value | CkC (9) | DbC (6) | DbE (6) | P value | |
Diastolic function | ||||||||
 E, m s−1 | 665 ± 28 | 641 ± 40 | 696 ± 50 | ND | 632 ± 25 | 680 ± 29 | 647 ± 57 | ND |
 A, m s−1 | 455 ± 34 | 508 ± 19 | 463 ± 34 | ND | 417 ± 24 | 510 ± 31 | 470 ± 45 | ND |
 E/A | 1.52 ± 0.12 | 1.26 ± 0.05 | 1.53 ± 0.12 | ND | 1.5 ± 0.08 | 1.35 ± 0.09 | 1.39 ± 0.06 | ND |
 Dt, ms | 29.4 ± 3.0 | 32.7 ± 3.9 | 27.8 ± 1.8 | ND | 24.9 ± 1.8 | 31.1 ± 3.3 | 26.3 ± 1.8 | ND |
 E′, m s−1 | 27.0 ± 1.8 | 14.0 ± 1.6* | 15.9 ± 2.2 | <0.001 | 26.9 ± 1.4 | 15.5 ± 1.7* | 20.4 ± 1.2 | <0.001 |
 A′, m s−1 | 21.5 ± 2.5 | 16.6 ± 0.8 | 18.0 ± 4.1 | ND | 19.0 ± 1.7 | 18.3 ± 2.7 | 11.9 ± 0.9§ | 0.036 |
 E′/A′ | 1.31 ± 0.09 | 0.84 ± 0.08* | 0.93 ± 0.07§ | 0.002 | 1.47 ± 0.11 | 0.89 ± 0.08*,†| 1.76 ± 0.17 | <0.001 |
 E/E′ | 25.3 ± 1.7 | 48 ± 5.6* | 47 ± 2.5§ | <0.001 | 24 ± 1.6 | 46 ± 4.4*,†| 29 ± 1.8 | <0.001 |
 (E/E′/IDd) | 8.7 ± 0.4 | 13.4 ± 1.8 | 12.4 ± 0.6 | ND | 7.8 ± 0.5 | 12.3 ± 1.3*,†| 7.8 ± 0.9 | 0.009 |
 IVRT, ms | 20.9 ± 1.8 | 19.9 ± 0.8 | 18.0 ± 1.0 | ND | 19.0 ± 2.3 | 16.0 ± 0.4 | 15.8 ± 0.4 | ND |
 LA, mm | 1.55 ± 0.10 | 2.35 ± 0.13* | 2.25 ± 0.10§ | <0.001 | 1.40 ± 0.06 | 1.97 ± 0.03* | 2.04 ± 0.1§ | <0.001 |
 Ao, mm | 1.21 ± 0.06 | 1.37 ± 0.02 | 1.42 ± 0.05 | 0.077 | 1.26 ± 0.06 | 1.29 ± 0.02 | 1.27 ± 0.05 | ND |
 LA/Ao | 1.29 ± 0.07 | 1.72 ± 0.09* | 1.60 ± 0.11a | 0.009 | 1.14 ± 0.08 | 1.54 ± 0.11* | 1.61 ± 0.1§ | 0.003 |
Parameter | Pre-treatment | Post-treatment | ||||||
---|---|---|---|---|---|---|---|---|
CkC (5) | DbC (6) | DbE (6) | P value | CkC (5) | DbC (6) | DbE (6) | P value | |
Systolic function | ||||||||
 EF, % | 72 ± 6 | 76 ± 1 | 71 ± 2 | ND | 74 ± 2 | 74 ± 3 | 76 ± 2 | ND |
 FS, % | 42 ± 5 | 44 ± 1 | 39 ± 2 | ND | 42 ± 2 | 43 ± 3 | 45 ± 2 | ND |
 CO, ml min−1 | 21 ± 2 | 41 ± 5* | 41 ± 4§ | 0.001 | 29 ± 3 | 49 ± 5* | 39 ± 5 | 0.02 |
 SV, μl | 56 ± 4 | 101 ± 11* | 95 ± 5§ | 0.016 | 63 ± 7 | 108 ± 9* | 87 ± 10 | 0.01 |
Left ventricle wall and lumen measures | ||||||||
 LVAWTd, mm | 0.70 ± 0.07 | 0.91 ± 0.05* | 0.85 ± 0.04 | 0.052 | 0.81 ± 0.05 | 0.82 ± 0.11 | 0.84 ± 0.05 | ND |
 LVIDd, mm | 3.40 ± 0.14 | 3.52 ± 0.11 | 3.68 ± 0.14 | ND | 3.50 ± 0.05 | 3.79 ± 0.17 | 3.86 ± 0.19 | ND |
 LVPWTd, mm | 0.69 ± 0.04 | 0.83 ± 0.04* | 0.78 ± 0.04 | 0.026 | 0.75 ± 0.02 | 0.92 ± 0.09 | 0.83 ± 0.05 | ND |
 LVIDs, mm | 2.00 ± 0.24 | 1.96 ± 0.08 | 2.23 ± 0.13 | ND | 2.13 ± 0.12 | 2.28 ± 0.17 | 2.27 ± 0.11 | ND |
 RWT | 0.41 ± 0.03 | 0.49 ± 0.03 | 0.45 ± 0.03 | ND | 0.45 ± 0.02 | 0.48 ± 0.08 | 0.43 ± 0.03 | ND |
 LVM, mg | 59 ± 3 | 86 ± 4* | 81 ± 3§ | 0.001 | 76 ± 3 | 97 ± 7 | 98 ± 9 | 0.073 |
 LVM/TL, mg mm−1 |  |  |  |  | 4.30 ± 0.17 | 5.56 ± 0.36 | 5.71 ± 0.52 | 0.057 |