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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

Fig. 3

IGF-IR contributes to basal VSMC migration. a Effect of PPP (IGF-IR inhibitor) at different doses on IGF-IR tyrosine phosphorylation of four VSMC lines. We performed the immunoprecipitation against IGF-IRβ followed by Western blot against p-tyrosine. b Effect of PPP on basal VSMC migration at 12 h by wound healing closure and the percentage of inhibition of VSMC migration induced by PPP. Experiments were performed 4–7 times. *p < 0.05, **p < 0.005, ***p < 0.001 vs. each control

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Cardiovascular Diabetology

ISSN: 1475-2840