Fig. 2

Effect of short-term (7 days) empagliflozin treatment on daily 24-h sodium balance (a), cumulative 24-h sodium balance (b), 24-h water balance (c), and cumulative 24-h water balance (d) of SHRcp. Control SHRcp fed control diet; SGLT2, SHRcp fed control diet containing empagliflozin; UGE urinary glucose excretion; NS not significant. Values are mean ± SEM n = 6 in control, n = 5 in SGLT2. Statistical analysis was performed by two-factor ANOVA with repeated measures followed by post hoc Bonferroni’s multiple comparisons test. ^#P < 0.05, *P < 0.01 versus control