Fig. 1

HRs and 95% CIs for biomarkers based on the presence or absence of DM, and statistical significance of the interaction covariate for DM and the biomarkers. A 1SD increase was used for HR calculations in the logarithm-transformed variables NTproBNP, hs-TnT, hs-CRP, cystatin-C, galectin-3, STfR, and neprilysin. ST2 analyses were performed for every 10 ng/mL change. Age was included as a covariate in the neprilysin analysis. For the quadratic form of ST2: p = 0.02 for all-cause death and p = 0.03 for cardiovascular death. For the quadratic form of log(hs-TnT): p = 0.82 for all-cause death and p = 0.1 for cardiovascular death. Interactions between DM and the quadratic form of ST2: p = 0.02 for all-cause death and p = 0.03 for cardiovascular death. Interactions between DM and the quadratic form of log(hs-TnT): p = 0.82 for all-cause death and p = 0.1 for cardiovascular death. hs-CRP, high-sensitivity C reactive protein; hs-TnT, high-sensitivity troponin T; NTproBNP, N-terminal pro-brain natriuretic peptide; STfR, soluble transferrin receptor