Fig. 5
Comparison of α1C-subunit expressions of CaL channel in cerebral arteries isolated from CON, CON +100 mg/kg/day berberine, diabetic, and diabetic +100 mg/kg/day berberine rats. Representative band was used to show the protein expressions of CaL channel in different groups (a). Normalized band intensities are shown as a percentage of the β-actin density (b). Chronic administration of 100 mg/kg/day berberine markedly reduced the augmented α1C-subunit expressions of CaL channel in cerebral arteries isolated from diabetic rats. CON control rats, CON + berberine control rats administrated with berberine (100 mg/kg/day), Diabetic diabetic rats, Diabetic + berberine diabetic rats administrated with berberine (100 mg/kg/day). Values are expressed as mean ± SEM from four independent experiments, and each sample based on tissue pooled from 3–4 animals. *P < 0.05 vs. CON rats and # P < 0.05 vs. diabetic rats