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Table 3 Multivariable Cox regression models showing the association between sTNFR1 and sTNFR2, with major cardiovascular events in all individuals and in those without kidney disease

From: Association of soluble tumor necrosis factor receptors 1 and 2 with nephropathy, cardiovascular events, and total mortality in type 2 diabetes

Biomarker

Model

Hazard ratio

95 % confidence intervals

p value

sTNFR1 all

A

1.68

(1.33–2.13)

<0.001

B

1.66

(1.29–2.14)

<0.001

C

1.61

(1.26–2.06)

<0.001

D

1.65

(1.29–2.11)

<0.001

E

1.79

(1.39–2.14)

<0.001

Without kidney disease

A

1.88

(1.42–2.25)

<0.001

B

1.94

(1.47–2.56)

<0.001

C

1.77

(1.32–2.39)

<0.001

D

1.85

(1.39–2.47)

<0.001

E

2.06

(1.51–2.82)

<0.001

sTNFR2 all

A

1.51

(1.17–1.93)

0.001

B

1.47

(1.13–1.91)

0.004

C

1.44

(1.10–1.88)

0.008

D

1.46

(1.13–1.89)

0.004

E

1.48

(1.14–1.93)

0.003

Without kidney disease

A

1.67

(1.25–2.25)

0.001

B

1.72

(1.29–2.28)

<0.001

C

1.56

(1.13–2.17)

0.008

D

1.70

(1.26–2.30)

0.001

E

1.74

(1.26–2.40)

0.001

  1. Model A: adjusted for age, and sex; Model B: adjusted for age, sex, eGFR and ACR; Model C: adjusted for age, sex, CRP IL-6; Model D: adjusted for age, sex, HbA1c, and diabetes treatment (diet, oral antidiabetics or insulin); Model E (secondary analysis): established cardiovascular risk factors (smoking, LDL-cholesterol, HDL-cholesterol, systolic blood pressure), cardiovascular medication, antihypertensive medication (ACE-inhibitors/ARBs, calcium channel blockers, beta blockers and diuretics), and lipid lowering treatment (statins), to model B