Fig. 7

Linear plots of left ventricular mass (LVM) at EDIC years 14–16 vs. LW-1 and CLF, as indicated. Preliminary Spearman correlation analysis showed that both LW-1 and CLF were significantly (P < 0.05) associated with LVM, but not SIF (P > 0.05). LW-1 and CLF were adjusted for age, diabetes duration and HbA1c (both DCCT and EDIC). However, LVM did not significantly correlate with any of these latter variables, thus no adjustments were made (P = 0.27, P = 0.98, P > 0.25, respectively). For both graphs (n = 142), the regression line and 95 % CI prediction are shown: (left) LVM = 59 + 0.021 (LW-1); (right) LVM = 59 + 0.081 (CLF). For each graph, the correlation (r) and significance (P) are inserted. Symbols used: see Fig. 1