Parameter | EF | FS | LVID d | LVID s | LV vol d | LV vol s | HR | SBP | DBP | LV mass |
---|---|---|---|---|---|---|---|---|---|---|
WT (n=6) | 91 ± 3 | 60 ± 4 | 2.7 ± 0.3 | 1.1 ± 0.1 | 27.8 ± 7.2 | 2.5 ± 0.5 | 619 ± 98 | 132 ± 4 | 81 ± 3 | 102 ± 22 |
EphA2-R-M (n=9) | 82 ± 4 | 49 ± 4* | 2.7 ± 0.2 | 1.4 ± 0.2 | 27 ± 5.7 | 4.8 ± 1.5 | 636 ± 71 | 129 ± 4 | 77 ± 2 | 71 ± 15 |
WT STZ (n=8) | 88 ± 2 | 57 ± 3 | 2.8 ± 0.2 | 1.2 ± 0.1 | 30.1 ± 4.7 | 3.6 ± 0.9 | 578 ± 98 | 185 ± 6* | 107 ± 11* | 69 ± 11 |
EphA2-R-M STZ (n=18) | 78 ± 6 | 46 ± 6● | 2.7 ± 0.2 | 1.5 ± 0.2 | 27.8 ± 5.6 | 6.1 ± 2.4 | 492 ± 142† | 148 ± 4 | 91 ± 3 | 60 ± 15 |
WT 4d (n=7) | 77 ± 1 | 45 ± 5 | 3.4 ± 0.4* | 1.9 ± 0.3 | 51.0 ± 14.1* | 13.5 ± 5.4* | 658 ± 91 | 129 ± 8 | 73 ± 5 | 169 ± 51 |
EphA2-R-M 4d (n-8) | 79 ± 3 | 46 ± 3 | 3.2 ± 0.1 | 1.7 ± 0.1 | 39.5 ± 2.2 | 8.5 ± 1.5 | 632 ± 93 | 126 ± 4 | 76 ± 3 | 94 ± 24‡ |
WT STZ + 4d (n=7) | 55 ± 13‡ | 28 ± 8‡ | 3.3 ± 0.3 | 2.4 ± 0.5‡ | 44.9 ± 10.0 | 21.0 ± 9.1‡ | 602 ± 98 | 127 ± 6 | 73 ± 7 | 107 ± 32‡ |
EphA2-R-M STZ + 4d (n=11) | 62 ± 12¥ | 33 ± 8¥ | 3.1 ± 0.7 | 2.1 ± 0.5 | 39.7 ± 18.6 | 15.4 ± 9.2 | 536 ± 80 | 130 ± 5 | 69 ± 2 | 81 ± 40 |