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Table 2 Medications

From: Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study

Variable

IR (+)

IR(-)

p-valuea

NGT

IGT

T2DM5#

p-valuea

n (%)

38 (18)

113 (54)

-

64 (31)

54 (26)

90 (43)

-

Glucose lowering treatment

       

Metformin, n (%)

0 (0)

1 (0.9)

0.748

0 (0)

1 (2)

64 (71)

<0.001*

Sulfonylurea, n (%)

0 (0)

1 (0.9)

0.748

0 (0)

0 (0)

1 (1)

<0.001*

Insulin therapy, n (%)

0 (0)

0 (0)

-

0 (0)

0 (0)

24 (34)

<0.001*

Thiazolidinediones, n (%)

0 (0)

0 (0)

-

0 (0)

0 (0)

2 (2)

0.266

Glinide, n (%)

0 (0)

0 (0)

-

0 (0)

0 (0)

2 (2)

0.266

Hypertension treatment

       

Beta-blocker, n (%)

23 (61)

72 (63)

0.434

33 (52)

39 (72)

62 (69)

0.033*

AT1 receptor blocker, n (%)

5 (13)

16 (14)

1.000

9 (14)

6 (11)

15 (17)

0.653

ACE-inhibitor, n (%)

24 (36)

65 (58)

0.573

31 (48)

37 (69)

55 (61)

0. 076

Calcium antagonist, n (%)

7 (18)

18 (16)

0.801

9 (14)

6 (11)

23 (26)

0.055

Diuretics, n (%)

12 (32)

31 (27)

0.679

16 (25)

16 (30)

31 (34)

0.450

Other Medications

       

Nitrate, n (%)

5 (13)

7 (6)

0.181

1 (2)

7 (13)

16 (18)

0.008*

Acetyl salicylic acid, n (%)

24 (63)

76 (68)

0.691

38 (60)

40 (74)

65 (73)

0.169

Clopidrogel, n (%)

11 (29)

34 (31)

1.000

13 (21)

18 (33)

28 (32)

0.259

Allopurinol, n (%)

5 (13)

6 (5.4)

0.147

3 (5)

3 (6)

15 (17)

0.022*

Aldosterone antagonist, n (%)

1 (3)

0 (0)

0.248

0 (0)

1 (2)

0 (0)

0.245

Statin, n (%)

16 (42)

60 (53)

0.423

27 (42)

28 (52)

49 (55)

0.598

  1. Values are median (interquartile range) or n (%).a Wilcoxon-Mann-Whitney-Test, Jonckheere-Terpstra test, Fisher or χ2 Test were used as appropriate, * statistically significant (p < 0,05). #Subjects with diabetes before inclusion or new detected diabetes based on oGTT results