Table 4 Period effects on cardiovascular risk factors after 3 and 6 months in all 13 subjects combined (mean ± SD)
Baseline | 3 months | 6 months | P* | |
|---|---|---|---|---|
HbA1C (%, Mono-S) | 6.6 ± 0.6 | 5.9 ± 0.9 | 5.6 ± 0.6 | 0.10 |
Cholesterol (mmol/l) | 4.4 ± 1.1 | 4.4 ± 1.1 | 4.3 ± 1.3 | 0.6 |
LDL (mmol/l) | 2.9 ± 0.9 | 2.8 ± 1.0 | 2.7 ± 1.0 | 0.5 |
HDL (mmol/l) | 1.3 ± 0.2 | 1.3 ± 0.3 | 1.3 ± 0.3 | 0.9 |
TG (mmol/l) | 1.5 ± 0.7 | 1.3 ± 0.7 | 1.2 ± 0.5 | 0.5 |
CRP (mg/l) | 2.4 ± 1.8 | 2.8 ± 2.5 | 1.8 ± 1.0 | 0.14 |
SBP (mmHg) | 150 ± 21 | 144 ± 16 | 145 ± 21 | 0.9 |
DBP (mmHg) | 83 ± 8 | 80 ± 8 | 82 ± 8 | 0.4 |
Weight (kg) | 87 ± 17 | 83 ± 15 | 82 ± 12 | 0.4 |
BMI (kg/m2) | 30 ± 7 | 29 ± 6 | 28 ± 4 | 0.4 |
Waist (cm) | 103 ± 14 | 96.8 ± 12 | 95 ± 9 | 0.5 |
fP-glucose (mmol/l) | 7.8 ± 1.2 | 7.1 ± 1.6 | 7.3 ± 1.3 | 0.5 |
fP-insulin (pmol/l) | 98 ± 44 | 74 ± 28 | 63 ± 21 | 0.2 |
AUC glucose (mmol/l·min) | 1607 ± 218 | 1438 ± 350 | 1437 ± 329 | 1.0 |
AUC glucose (mmol/l·min)1 | 667 ± 186 | 583 ± 189 | 558 ± 219 | 0.6 |
AUC insulin (nmol/l·min) | 30 ± 12 | 29 ± 12 | 23 ± 14 | 0.01 |
AUC insulin (nmol/l·min)1 | 18 ± 8 | 21 ± 11 | 16 ± 13 | 0.01 |
ISI0,120 (mg·l2/mmol·mU·min) | 40 ± 9 | 50 ± 16 | 56 ± 25 | 0.2 |
HOMA2 %B | 65 ± 34 | 65 ± 27 | 53 ± 18 | 0.04 |
HOMA2 %S | 59 ± 27 | 80 ± 42 | 87 ± 28 | 0.6 |
HOMA2 IR | 2.0 ± 0.8 | 1.5 ± 0.6 | 1.3 ± 0.4 | 0.2 |
Diabetic values at OGTT yes/no (n) | 12/1 | 8/5 | 9/4 | 1.0 |