Table 3 qRT-PCR-based fold changes in gene expression in control vs diabetic GK rats treated with or without ABT-627.
Aorta | Â | Mesenteric artery | ||
|---|---|---|---|---|
| Â | C vs GK | GK vs GK+ABT627 | C vs GK | GK vs GK+ABT627 |
MMP-2 | ↑10* | No change | ↑11* | ↓3** |
MMP-9 | ↑3* | No change | ↑10* | ↓2** |
MT1-MMP | ↑6* | No change | ↑7* | ↓7** |
COL1A1 | ↑27* | No change | ↑7* | ↓8** |
Fibronectin | ↑1.23 | ↓1.25 | ↑9* | ↓3** |
c-Fos | ↓3* | ↑2 | ↓3* | ↑2** |
c-Jun | ↑3* | No change | ↑3* | ↓5** |