Table 1 Genes related to the insulin signaling cascade which are specifically modulated by OxLDL in comparison to mmLDL and vehicle in hyperinsulinemic hyperglycemic conditions.
From: Insulin and glucose play a role in foam cell formation and function
| Â | Â | Mean absolute intensity | Â | Â | Â | ||
|---|---|---|---|---|---|---|---|
Description | Locus Link | Vehicle | mmLDL | OxLDL | Fold change: OxLDL vs. Vehicle | P: OxLDL vs. Vehicle | P: OxLDL vs. mmLDL |
Insulin receptor | 3643 | 19.7 | 33.0 | 76.8 | 3.90 | <0.004 | <0.009 |
Insulin receptor substrate 2 (IRS2) | 8660 | 193.0 | 199.0 | 471.1 | 2.44 | <0.000001 | <0.000001 |
Glucose-6-phosphate dehydrogenase | 2539 | 1665.8 | 3410.6 | 3866.6 | 2.32 | <0.000001 | N.S.* |
Insulin induced gene 1 (Insig-1) | 3637 | 1485.7 | 1024.8 | 274.6 | -5.41 | <0.000001 | <0.000001 |
Phosphoinositide-3-kinase. Catalytic; delta polypeptide (PIK3CD) | 5293 | 1890.4 | 1427.2 | 984.2 | -1.92 | <0.000001 | = 0.001 |