Figure 9

PV loop analysis before and after I/R in diabetic rats. The parameters of PV loop analysis are derived from LV pressure and LV volume. Ventricular contractility assessment is shown in maximum rising (+dP/dt, A) and falling (-dP/dt, B) velocity, left ventricular end systolic (LVESP, C) and end diastolic pressure (LVEDP, D) of the ventricular pressure that occurs during the cardiac cycle. E, ejection fraction (%). F, stroke volume. G, stroke work. Arterial elastance (Ea, H). End-systolic pressure volume relationship (ESPVR, I) and end-diastolic pressure volume relationship (EDPVR, J). Preload recruitable stroke work (PRSW, K). All values are represented as mean ± SEM before (baseline) and after I/R (I/R). *P < 0.05 compared to age- and sex-matched non-diabetic control rats. ^#P < 0.05 versus age- and sex-matched diabetic rats treated with vehicle.