Effects of metformin and exercise training, alone or in association, on cardio-pulmonary performance and quality of life in insulin resistance patients

Table 4 Differences between metabolic and anthropometric features after and before 12 weeks of therapy

				P value
	M	MEx	EX	M vs MEx	M vs EX	MEx vs EX
Homa	-1.98 [-2.87 to -1.08]	-2.21 [-3.34 to -1.08]	2.31 [1.60 to 3.02]	ns	ns	ns
BMI (Kg/m²)	-1.35 [-2.27 to -0.43]	-1.99 [-2.24 to -1.74]	0.67 [-0.01 to 1.35]	ns	< 0.01	< 0.01
VO2 (l/min)	-0.09 [-0.15 to -0.03]	0.19 [0.05 to 0.33]	0.26 [0.05 to 0.47]	< 0.01	< 0,01	ns
%	-4.70 [-7.31 to -2.1]	8.11 [1.37 to 14.85]	14.42 [9.31 to 19.53]	< 0.01	< 0.01	ns
WORK(Watt)	-3.72 [-9.85 to -2.41]	21.85 [12.52 to 31.17]	10.22 [1.45 to 18.99]	< 0.01	< 0.01	ns
AT (l/min)	-0.06 [-0.14 to 0.02]	-0.04 [-0.13 to 0.05]	0.18 [0.15 to 0.22]	ns	< 0.01	< 0.01

Abbreviations: HOMA Homeostasis Model Assessment, BMI Body Mass Index, VO2 Maximum oxygen uptake, % VO2peak Maximum oxygen uptake in percentage compared to normal values, Work Maximum work, AT Anaerobic threshold.

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