Effects of metformin and exercise training, alone or in association, on cardio-pulmonary performance and quality of life in insulin resistance patients

Table 3 Metabolic features before and after 12 weeks of therapy

	Metformin			Exercise Training			Metformin and Exercise Training
	PRE	POST	P value	PRE	POST	P value	PRE	POST	P value
Homa	5.1 ± 3.0	3.1 ± 1.3	<0.05	5.5 ± 3.3	3.2 ± 1.1	<0.05	5.6 ± 2.1	3.3 ± 1.2	<0.05
BMI (Kg/m²)	29.7 ± 4.8	28.4 ± 4.6	<0.05	28.3 ± 4.7	28.9 ± 5.6	ns	31.8 ± 3.8	29.8 ± 3.8	<0.01
VO2 (l/min)	1.5 ± 0.4	1.5 ± 0.3	<0.01	1.4 ± 0.1	1.70 ± 0.5	<0.05	1.7 ± 0.5	1.8 ± 0.4	<0.05
%	70.7 ± 9.9	66.7 ± 8.6	<0.01	67.5 ± 6	82.0 ± 17.9	<0.05	76.3 ± 18.1	84.4 ± 16.8	<0.05
WORK (Watt)	108 ± 32	104 ± 30	Ns	104 ± 18	114 ± 8	<0.05	115 ± 27	137 ± 33	<0.01
AT (l/min)	1.0 ± 0.3	1.0 ± 0.2	Ns	0.9 ± 0.1	1.1 ± 0.1	<0.05	1.09 ± 0.3	1.05 ± 0.15	<0.05
VE/VCO2	28.2 ± 2.4	27.8 ± 3.3	Ns	22.4 ± 3.2	23.7 ± 1.9	Ns	23.2 ± 2.3	22.2 ± 1.6	<0.05
VO2/WORK	9.5 ± 1.3	9.2 ± 0.8	Ns	9.7 ± 0.9	9.43 ± 3.3	Ns	9.3 ± 1.3	9.3 ± 0.8	Ns

Abbreviations: HOMA Homeostasis Model Assessment, BMI Body Mass Index, VO2peak Maximum oxygen uptake, % VO2 Maximum oxygen uptake in percentage compared to normal values, Work Maximum work, AT Anaerobic threshold, VE max Ventilation at maximum exercise, VCO2 carbon dioxide production, VO2/Work Oxygen uptake-Work rate relationship, VE/VCO2 Ventilatory equivalent for carbon dioxide.

ISSN: 1475-2840