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Figure 8 | Cardiovascular Diabetology

Figure 8

From: High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

Figure 8

Diabetes increased Smad activity. Smad7, an inhibitory Smad, increases as TGF-β/Smad activity increases. Diabetes increased Smad activity compared to control animals. Treatment with curcumin reduced diabetes enhanced TGF-β/Smad activity. Whole hearts were used for analysis. Smad7 mRNA levels expressed as fold change relative to housekeeping gene RPL32. (*p < 0.01 c/w control, †p < 0.05 c/w vehicle treated diabetic Ren-2 rats).

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Cardiovascular Diabetology

ISSN: 1475-2840