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Figure 1 | Cardiovascular Diabetology

Figure 1

From: The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus

Figure 1

The phospholipids component of HDL from T2DM enhanced COX-2 expression and PGI-2 release. A-B: glycated HDL (equal to 30 μg/ml of HDL) loss its function in regulation COX-2 expression compared with N-HDL (A) and diabetic HDL (equal to 30 μg/ml of HDL) has more increased COX-2 expression than glycated HDL (equal to 30 μg/ml of HDL) (B). C-D: HDL only containing protein components without any the lipid from N-HDL (N-apoHDL) (equal to 30 μg/ml of HDL) is more functional than it’s from diabetes mellitus (D-apoHDL) (equal to 30 μg/ml of HDL) in regulating COX-2 expression (C) and the preservation of phospholipids and protein components of HDL from type 2 diabetes mellitus, D-apoHDL&PL (equal to 30 μg/ml of HDL), reversed the function in regulating COX-2 expression compared with the control subjects, N-apoHDL&PL (equal to 30 μg/ml of HDL) (D). Each experiment was repeated three times.

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Cardiovascular Diabetology

ISSN: 1475-2840