From: Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle
Basal
GKA (RO28-1675) (10 μM)
TGF-β (2 ng/ml)
Vmax
0.14 ± 0.02
0.17 ± 0.02
0.21 ± 0.01
Km
6.42 ± 1.97
9.08 ± 2.12
4.47 ± 0.83
R2
0.83
0.92
0.91