Figure 5From: Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathwayCompared to control cells, compared to control cells, rapamycin along increased the autophagy level indicated by the number of average number of LC3-labeled puncta per cell (Figure 5). RAGE antibody pretreatment markedly reduced the formation of autolysosome in cultured cardiomyocytes, which can be induced again by the addition of rapamycin.Back to article page