Figure 2From: High glucose induces human endothelial dysfunction through an Axl-dependent mechanismHG concentrations and Gas6/Axl, ICAM-1 and VCAM-1 expression in HMEC-1Â s. HMEC-1Â s were cultured in 5, 20 and 40Â mM glucose and equimolar concentrations of mannitol for 24Â h. (A,B) Gas6/Axl mRNA and Axl proteins expression were decreased by HG. (C) The expressions of ICAM-1 and VCAM-1 proteins were increased with a glucose dose-dependent manner. HMEC-1Â s grown in mannitol did not change in Gas6/Axl, ICAM-1 and VCAM-1 expression.Back to article page