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Table 3 Odds ratio and 95% CI for the individual components of the MetS according to tertiles of serum sTWEAK concentrations

From: Reduced circulating sTWEAK levels are associated with metabolic syndrome in elderly individuals at high cardiovascular risk

 

Tertiles of sTWEAK concentrations

 

Effects on components of the MetS

1st tertile

2nd tertile

3rd tertile

P value for trend*

 

<453.1 ng/mL

453.1 to <706.4 ng/mL

≥706.4 ng/mL

 

Abdominal obesity

    

No. abdominal obesity/No. non abdominal obesity

120/30

94/57

108/43

 

Crude model

1.60 (0.93 - 2.71)

0.65 (0.40 - 1.06)

1.00 [Ref.]

0.091

Model 1

2.01 (1.15 - 3.52)

0.86 (0.51 - 1.43)

1.00 [Ref.]

0.012

Model 2

2.03 (1.14 - 3.60)

0.88 (0.52 - 1.47)

1.00 [Ref.]

0.013

Model 3

1.85 (1.03 - 3.33)

0.87 (0.51 - 1.47)

1.00 [Ref.]

0.036

Hyperglycemia

    

No. hyperglycemia/No. non hyperglycemia

74/76

60/91

49/102

 

Crude model

2.03 (1.27 - 3.23)

1.37 (0.86 - 2.19)

1.00 [Ref.]

0.003

Model 1

1.94 (1.20 - 3.11)

1.29 (0.80 - 2.09)

1.00 [Ref.]

0.006

Model 2

1.95 (1.20 - 3.19)

1.37 (0.84 - 2.24)

1.00 [Ref.]

0.007

Model 3

1.71 (1.04 - 2.83)

1.37 (0.82 - 2.27)

1.00 [Ref.]

0.037

Hypertriglyceridemia

    

No. hypertriglyceridemia/No. nonhypertriglyceridemia

60/90

54/97

41/110

 

Crude model

1.79 (1.10 - 2.90)

1.49 (0.92 - 2.46)

1.00 [Ref.]

0.021

Model 1

1.73 (1.05 - 2.82)

1.40 (0.85 - 2.31)

1.00 [Ref.]

0.031

Model 2

1.97 (1.18 - 3.30)

1.44 (0.86 - 2.42)

1.00 [Ref.]

0.010

Model 3

1.68 (1.02 - 2.79)

1.36 (0.82 - 2.26)

1.00 [Ref.]

0.041

Low HDL-cholesterol

    

No. low HDL-cholesterol/No. non low HDL-cholesterol

31/119

31/120

38/113

 

Crude model

0.77 (0.45 - 1.33)

0.76 (0.44 - 1.31)

1.00 [Ref.]

0.355

Model 1

0.81 (0.47 - 1.41)

0.81 (0.47 - 1.42)

1.00 [Ref.]

0.478

Model 2

0.86 (0.48 - 1.52)

0.82 (0.46 - 1.46)

1.00 [Ref.]

0.614

Model 3

0.67 (0.36 - 1.24)

0.71 (0.39 - 1.29)

1.00 [Ref.]

0.207

Hypertension

    

No. hypertension/No. non hypertension

148/2

143/8

148/3

 

Crude model

1.50 (0.25 - 9.10)

0.36 (0.09 - 1.39)

1.00 [Ref.]

0.697

Model 1

1.51 (0.25 - 9.30)

0.37 (0.09 - 1.47)

1.00 [Ref.]

0.653

Model 2

1.67 (0.25 - 11.26)

0.33 (0.08 - 1.36)

1.00 [Ref.]

0.619

Model 3

1.22 (0.18 - 8.42)

0.33 (0.07 - 1.41)

1.00 [Ref.]

0.929

  1. Results expressed as odds ratios (95% CI) for MetS components from logistic regression analysis. Abbreviations: MetS Metabolic Syndrome, sTWEAK soluble TNF-like weak inducer of apoptosis.
  2. Crude model: unadjusted; Model 1: Adjusted for gender and age; Model 2: Additionally adjusted for family history of diabetes and premature CHD (yes/no), educational level (primary education vs secondary/higher education), alcohol intake (g alcohol/d), smoking (current/not-current), physical activity (sedentary vs active) and eGFR; Model 3: Additionally adjusted for the presence of abdominal obesity (except for abdominal obesity), hyperglycemia (except for hyperglycemia), hypertriglyceridemia (except for hypertriglyceridemia), low HDL-cholesterol (except for low HDL-cholesterol), hypertension (except for hypertension). *Linear trend tests were calculated using the median serum sTWEAK concentrations of each category and using them as a new continuous variable in the models.
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Cardiovascular Diabetology

ISSN: 1475-2840