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Figure 2 | Cardiovascular Diabetology

Figure 2

From: CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models

Figure 2

CNX-012-570 improves insulin sensitivity and glucose tolerance in DIO and db/db mice. (A) OGTT in DIO mice on week 8 of treatment. Open square-Lean control, closed square -HFD control and Triangle-CNX-012-570 (3 mpk, qd). (D) Fed glucose levels in db/db mice study were monitored weekly. (B & E) Fasting insulin, (C & F) HOMA IR in both DIO and db/db mice were measured at week 8 and 6 respectively. Clear bar-lean control, black bar-HFD or db/db control, grey bar-CNX-012-570 treatment (3 and 2.5 mg/kg, orally once a day in DIO and db/db mouse respectively). All the values are expressed as Mean ± SEM. Statistical comparison between control and treatment group was conducted by One-way ANOVA followed by Dunnett’s test (*P < 0.05, ** P < 0.01 and *** P < 0.001).

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Cardiovascular Diabetology

ISSN: 1475-2840