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Table 2 Numbers and infarct size

From: Angiotensin-converting enzyme inhibition and food restriction restore delayed preconditioning in diabetic mice

  

Wild type

Ob/ob

DKO

 

Condition

Sham

NP

P

Sham

NP

P

Sham

NP

P

N experiments (survivors)

Untreated

8 (8)

11 (9)

9 (9)

6 (6)

9 (6)

8 (7)

7 (6)

7 (6)

8 (7)

Diet

   

7 (6)

9 (6)

8 (7)

7 (6)

7 (7)

8 (8)

ACE-I

6 (6)

7 (6)

8 (8)

7 (7)

9 (7)

8 (7)

7 (7)

9 (7)

8 (7)

Weight (g)

Untreated

28.3±4.6

62.4±3.8 a

59.1±9.5 a

Diet

 

38.3±4.7 b

37.9±3.4 b

ACE-I

27.1±3.4

62.9±9.4 ae

63.6±8.5 ae

Area at risk (% of heart)

Untreated

0

15.4±7.6 c

16.6±6.9 c

0

15.6±6.1c

12.4±5.5 c

0

18.8±7.6 c

12.9±3.5 c

Diet

   

0

18.7±2.6 c

19.4±6.6 c

0

17.5±8.7 c

17.9±10.7 c

ACE-I

0

19.0±5.8 c

18.8±7.4 c

0

16.4±3.0 c

17.5±8.8 c

0

14.4±5.3 c

16.1±7.1 c

Infarct size (% of area at risk)

Untreated

0

50.2±6.5 c

28.9±12.3 cd

0

72.7±8.0 ac

62.9±7.8 ac

0

67.4±6.6 ac

65.1±7.1 ac

Diet

   

0

66.8±9.7 c

56.5±6.4 cd

0

71.2±12.3 c

57.7±7.6 cd

ACE-I

0

53.2±3.5 c

23.6±6.1 cd

0

69.6±8.6 ac

49.7±5.5 abcde

0

66.4±7.8 ac

53.3±10.4 abcd

  1. ACE-I: angiotensin-converting enzyme inhibition; DKO: double knock-out (ob/ob; LDLR-/-); NP: ischemia/reperfusion and Non-Preconditioned; P: ischemia/reperfusion and Preconditioned. “a” p<0.05 versus WT same treatment, same condition (sham; non-preconditioned; preconditioned); “b” p<0.05 versus same untreated genotype, same condition; “c” p<0.05 versus sham, same genotype, same treatment; “d” p<0.05 versus non-preconditioned, same genotype, same treatment; “e” p<0.05 versus diet, same genotype, same condition.