Wild type | Ob/ob | DKO | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Condition | Sham | NP | P | Sham | NP | P | Sham | NP | P | |
N experiments (survivors) | Untreated | 8 (8) | 11 (9) | 9 (9) | 6 (6) | 9 (6) | 8 (7) | 7 (6) | 7 (6) | 8 (7) |
Diet | 7 (6) | 9 (6) | 8 (7) | 7 (6) | 7 (7) | 8 (8) | ||||
ACE-I | 6 (6) | 7 (6) | 8 (8) | 7 (7) | 9 (7) | 8 (7) | 7 (7) | 9 (7) | 8 (7) | |
Weight (g) | Untreated | 28.3±4.6 | 62.4±3.8 a | 59.1±9.5 a | ||||||
Diet | 38.3±4.7 b | 37.9±3.4 b | ||||||||
ACE-I | 27.1±3.4 | 62.9±9.4 ae | 63.6±8.5 ae | |||||||
Area at risk (% of heart) | Untreated | 0 | 15.4±7.6 c | 16.6±6.9 c | 0 | 15.6±6.1c | 12.4±5.5 c | 0 | 18.8±7.6 c | 12.9±3.5 c |
Diet | 0 | 18.7±2.6 c | 19.4±6.6 c | 0 | 17.5±8.7 c | 17.9±10.7 c | ||||
ACE-I | 0 | 19.0±5.8 c | 18.8±7.4 c | 0 | 16.4±3.0 c | 17.5±8.8 c | 0 | 14.4±5.3 c | 16.1±7.1 c | |
Infarct size (% of area at risk) | Untreated | 0 | 50.2±6.5 c | 28.9±12.3 cd | 0 | 72.7±8.0 ac | 62.9±7.8 ac | 0 | 67.4±6.6 ac | 65.1±7.1 ac |
Diet | 0 | 66.8±9.7 c | 56.5±6.4 cd | 0 | 71.2±12.3 c | 57.7±7.6 cd | ||||
ACE-I | 0 | 53.2±3.5 c | 23.6±6.1 cd | 0 | 69.6±8.6 ac | 49.7±5.5 abcde | 0 | 66.4±7.8 ac | 53.3±10.4 abcd |