Cardiovascular Diabetology

Table 2 Association result for the HP duplication with measures of subclinical CVD and blood lipids

From: Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study

HP Duplication – CVD Association Results
		Additive		Dominant		Recessive
	N	Beta ± SE	p-value	Beta ± SE	p-value	Beta ± SE	p-value
CAC	1134	0.022±0.097	0.82	−0.025±0.135	0.85	0.135±0.189	0.48
CarCP	1142	−0.159±0.102	0.12	−0.180±0.142	0.21	−0.255±0.200	0.20
AACP	865	−0.025±0.102	0.81	−0.117±0.141	0.41	0.141±0.202	0.48
IMT	1103	−0.008±0.003	0.01	−0.014±0.004	0.001	−0.002±0.006	0.79
Cholesterol	1188	0.006±0.010	0.53	0.014±0.013	0.28	−0.005±0.019	0.78
Triglycerides	1188	0.060±0.024	0.01	0.091±0.033	0.005	0.050±0.047	0.28
Prevalent CVD	1084	−0.033 ± 0.061	0.58	0.006 ± 0.083	0.94	−0.140 ± 0.117	0.23
All Cause Mortality	1208	0.063 ± 0.065	0.33	0.123 ± 0.089	0.17	−0.004 ± 0.129	0.98
CVD Mortality	1208	0.145 ± 0.081	0.07	0.222 ± 0.101	0.04	0.117 ± 0.116	0.47

Associations were examined under additive, dominant and recessive genetic models. Bold indicates statistical significance. CAC: coronary artery calcified plaque; CarCP: carotid artery calcified plaque; AACP: abdominal aortic calcified plaque; IMT: carotid intima-media thickness. SE = standard error.

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