Figure 3

Oxidative stress. Vascular ROS formation in isolated aortic segments of diabetic (A) and non-diabetic (B) ApoE^−/− and ApoE^−/−/AT1R^−/−-mice were assessed by L-012 chemiluminescence. Diabetic ApoE^−/−-mice showed enhanced oxidative stress compared to ApoE^−/−/AT1R^−/−-mice and telmisartan-treated ApoE^−/−-mice. Treatment of diabetic ApoE^−/− and ApoE^−/−/AT1R^−/−-mice with GW9662 raised the levels of oxidative stress to the range found in diabetic ApoE^−/−-mice. ^*P < 0.05 vs. diabetic and non-diabetic ApoE^−/−, ^#P < 0.05 vs. diabetic and non-diabetic ApoE^−/−/AT1R^−/−, ^‡P < 0.05 vs diabetic ApoE^−/− + GW9662, n = 6-8 per group.