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Table 2 C-statistics and net reclassification improvement (NRI) for the conventional risk markers alone, and in combination with one or more novel risk marker

From: Interleukin-6 and activin A are independently associated with cardiovascular events and mortality in type 2 diabetes: the prospective Asker and Bærum Cardiovascular Diabetes (ABCD) cohort study

 

Harrell’s C

NRI, P-value

Standard (STD) model alone

0.794

Reference model

STD + IL-6

0.913

43.2%, p = 0.001

STD + log ActivinA

0.859

20.3%, p = 0.013

STD + IL-6 + log ActivinA

0.923

46.5%, p < 0.001

STD + E/Em + pathol recovery loop

0.891

21.5%, p = 0.099

  1. The NRI calculations are based on estimated probabilities of event from logistic regression models. The three risk categories used are defined by the probability cut-offs 5% and 10%.
  2. STD model: age, gender, known CVD, diastolic blood pressure, microalbuminuria and serum levels of HDL-cholesterol and creatinine
  3. Abbreviations: STD Standard, IL-6 Interleukin-6, pathol Pathological.
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Cardiovascular Diabetology

ISSN: 1475-2840