Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Table 5 Effect of ischemic postconditioning in patients with acute myocardial infarction

First author	% of DM	Age	Protocol	Results
				ST resolution	LV function	Enzyme release	Infarct size
Ischemic PostC
Staat	20 vs. 13	58 vs. 56	4x 60sR/I	Improved	N/A	Reduced (peak, AUC)	N/A
Laskey	N/A	58 vs. 58	2x 90sR/I	Improved	N/A	Nochange (peak)	N/A
Ma	38 vs. 45	64 vs. 64	3x 30sR/I	N/A	Improved WMSI	Reduced (peak)	N/A
Yang	26 vs. 28	59 vs. 63	3x 30sR/I	No change	No change	Reduced (AUC)	Reduced (SPECT, 1w)
Thibault	12 vs. 10	56 vs. 56	4x 60sR/I	N/A	Improved EF, WMSI	Reduced (AUC)	Reduced (SPECT, 6m)
Laskey	38 vs. 42	60 vs. 58	2x 90sR/I	Improved	No change	Reduced (peak)	N/A
Xue	21 vs. 29	54 vs. 62	4x 60sR/I	Improved	Improved EF, WMSI	Reduced (peak, AUC)	Reduced (SPECT, 1w)
Lønborg	7 vs. 7	61 vs. 62	4x 30sR/I	No change	No change	N/A	Reduced (CMR, 3m)
Sörensson	25 vs. 17	63 vs. 62	4x 60sR/I	N/A	No change *1	No change (AUC)	No change (CMR, 1w) *1
Freixa	23 vs. 17	59 vs. 60	4x 60sR/I	N/A	No change	No change (peak)	No change (CMR, 1w & 6m)
Tarantini	18 vs. 3	60 vs. 60	4x 60sR/I	No change	No change	No change (AUC)	No change (CMR, 1m)

DM diabetes mellitus, MBG myocardial blush grade, CF coronary flow, WMSI wall motion score index, EF ejection fraction, AUC area under the curve, MACE major adverse cardiac events, SPECT single photon emission computed tomography, CMR cardiovascular magnetic resonance, w week, m month;
*1 Improved by postconditioning with large area at risk.

ISSN: 1475-2840