Table 2 Effect of hyperglycemia on infarct size
Species | Duration of hyperglycemia | Blood sugar (mg/dl) | Index ischemia | Â | First author | Journal |
|---|---|---|---|---|---|---|
| Â | Â | Â | min | type | Â | Â |
Hyperglycemia | ||||||
Infarct size enlargement | ||||||
Dog | before I | 585 vs. 71 | 60 | regional, vivo | Kersten | Am J Physiol 1998 |
Rabbit (NZ white) | throughout | 594 vs. 99 | 30 | regional, vitro | Wong | J Diabetes Complications 2011 |
Rat (SD) | during I | 324 vs 85 | 30 | regional, vivo | Su | Am J Physiol 2007 |
No change in infarct size | ||||||
Dog | before I | 310 vs. 71 | 60 | regional, vivo | Kersten | Am J Physiol 1998 |
Dog | before I | 310 vs. 75 | 60 | regional, vivo | Kersten | Am J Physiol 2001 |
Dog | before I | 316, 579 vs. 78 | 60 | regional, vivo | Kehl | Anesthesiology 2002 |
Dog | before I | 307 vs 83 | 60 | regional, vivo | Gu | Anesthesiology 2008 |
Rabbit (NZ white) | before and during I | 660 vs. 185 | 30 | regional, vivo | Ebel | Pflugers Arch 2003 |
Rabbit (NZ white) | before I | 257 vs 124 | 30 | regional, vivo | Amour | Anesthesiology 2010 |
Rabbit (NZ white) | before and during I | 338 vs 142 | 40 | regional, vivo | Raphael | J Cardiovasc Pharmacol 2010 |
Rat (SD) | before and during I | 360 vs 112 | 30 | regional, vivo | Ichinomiya | Cardiovasc Diabetol 2012 |
Rat (Wistar) | before and during I | >400 vs. 121 | 25 | regional, vivo | Weber | Eur J Pharmacol 2008 |
Rat (Wistar) | before and during I | 459 vs 128 | 25 | regional, vivo | Huhn | Br J Anaesth 2008 |
Rat (Wistar) | before and during I | 355 vs 89 | 30 | regional, vivo | Matsumoto | Cardiovasc Diabetol 2012 |
Metabolic syndrome | ||||||
Infarct size enlargement | ||||||
Rat (Wistar) | Western diet for 16 w | 95 vs 87 | 40 | regional, vitro | du Toit | Am J Physiol 2008 |
No change in infarct size | ||||||
Rat (SD) | high fat diet for 13 w | 160 vs 144 | 45 | regional, vivo | Thim | Clin Sci (Lond) 2006 |
Rat (WOKW) | (28 w old) | 105 vs. ? | 30 | regional, vivo | Wagner | J Cardiovasc Pharmacol 2008 |