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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability

Figure 3

StAR overexpression reduced inflammatory factors expression and secretion after palmitic acid treatment in RAECs. RAECs were infected with Ad-CMV-EGFP or Ad-CMV-StAR at MOI = 10 for 48 h and treated with PA (200 μM) in time-course. (A through D) The mRNA levels of IL-1β, TNFα, IL-6, VCAM-1 were analyzed by real-time quantitative PCR. Data represented as a ratio of gene-to-GAPDH expression (relative mRNA levels) and fold change over the relative mRNA levels at 0 h. (E through G) The contents of IL-1β, TNFα, IL-6 in culture supernatant were detected by ELISA. Data represents the means ± S.D. from three independent experiments. * represents P < 0.05.

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Cardiovascular Diabetology

ISSN: 1475-2840