Table 3 Comparison of areas under the ROC curves (95% CI) for potential markers of insulin resistance (HOMA-IR ≥2.5) of subjects categorized by body mass index

Body mass index characteristics	AUC (95% CI)
	Total	P-value	Non-obese	P-value	Overweight	P-value
	All N = 1,342		<25.0 kg/m² N = 998		≥25.0 kg/m² N = 344
Triglycerides (mg/dL)	0.69 (0.65-0.73)	<0.001	0.66 (0.59-0.73)	<0.001	0.65 (0.58-0.71)	<0.001
High sensitivity CRP (mg/dL)	0.68 (0.64-0.72)	<0.001	0.61 (0.55-0.68)	0.003	0.63 (0.57-0.70)	<0.001
Serum HMW adiponectin (μg/mL)	0.32 (0.28-0.36)	<0.001	0.32 (0.25-0.39)	<0.001	0.40 (0.33-0.46)	0.003
GGT (IU/L)	0.63 (0.58-0.67)	<0.001	0.61 (0.54-0.67)	0.005	0.54 (0.48-0.61)	0.211
ALT (IU/L)	0.69 (0.64-0.73)	<0.001	0.62 (0.55-0.69)	0.002	0.66 (0.59-0.72)	<0.001
AST (IU/L)	0.56 (0.51-0.61)	0.013	0.49 (0.41-0.57)	0.818	0.59 (0.52-0.66)	0.007
ALT/AST ratio	0.74 (0.70-0.78)	<0.001	0.70 (0.63-0.77)	<0.001	0.66 (0.59-0.72)	<0.001

ROC, receiver operating characteristics; CI, confidence interval; AUC, area under ROC curve. Data for triglycerides, high sensitivity CRP, serum HMW adiponectin, GGT, ALT, AST, and ALT/AST ratio were skewed and log-transformed for analysis.

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