Proteasome Modulator 9 SNPs are linked to hypertension in type 2 diabetes families

Table 1 Non-parametric and Parametric Linkage Analysis of Hypertension in the 200 Italian Families by Merlin software.

Phenotype	Prevalence	Families	Lod Score	P	Empirical P
Non-Parametric	94.60%	129	3.32	0.00005	0.001
Dominant Model; SNPs Cluster	94.60%	129	2.282	0.001202	0.000
Recessive Model; SNPs Cluster	94.60%	129	1.979	0.002561	0.000
Additive Model; SNPs Cluster	94.60%	129	0.926	0.039048	0.000

Prevalence = phenotype prevalence among the family subjects studied; Families = families number analyzed; Lod score = derived from the non-parametric linkage analysis or the parametric analysis cluster-based by Merlin; P = p-value; Empirical P = p-value derived from 1000 replicates by using the gene dropping method. Hypertension is indicated as presence of blood pressure ≥ 130/80 in absence of medications or presence at least of one anti-hypertensive drug.

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