Table 5 Relative changes in gene expression connected with oxidative stress and inhibition of angiogenesis for white (WAT) and brown (BAT) adipose tissues of eNOS -/- and DDAH animals vs. control mice.
| Â | Â | WAT | BAT | ||
|---|---|---|---|---|---|
| Â | Â | eNOS-/- | DDAH | eNOS-/- | DDAH |
Anti-Angiogenic genes | |||||
Adhesion | Â | Â | Â | Â | Â |
thrombospondin 1 | Thbs1 | ↓ |  |  |  |
thrombospondin 2 | Thbs2 | ↓ | ↓ |  |  |
Collagen |  | ↑7subunits | ↑3subunits |  |  |
|  |  |  | ↓ 1 subunit |  |  |
laminin B1 | Lamb1-1 |  |  |  | ↑ |
Laminin alpha | Lama |  | ↑ |  |  |
Laminin beta | Lamb |  | ↑ |  |  |
integrin alpha | Itga6 |  | ↓ | ↑ |  |
|  | Itga7 | ↑ |  |  |  |
|  | Itga8 | ↑ | ↓ |  |  |
|  | Itgam | ↓ | ↑ |  |  |
MMP's | Â | Â | Â | Â | |
tissue inhibitor of metalloproteinase | Timp3 |  | ↓ |  |  |
|  | Timp4 | ↓ | ↓ | ↓ |  |
Apoptosis | Â | Â | Â | Â | |
nuclear factor of kappa B | Nfkbia | ↓ | ↓ |  |  |
caspase | Casp7 |  |  |  | ↓ |
|  | Casp8 |  |  |  | ↑ |
BCL2-associated X protein | Bax | ↓ |  |  |  |
conserved helix-loop-helix ubiquitous kinase | Chuk |  | ↑ |  |  |
transformation related protein 53 | Trp53 | ↑ |  |  |  |
BCL2-related ovarian killer protein | Bok | ↑ |  |  |  |
X-linked inhibitor of apoptosis |  |  | ↑ |  | ↑ |
Oxidative stress | |||||
Repression of ROS production | Â | Â | Â | Â | |
cytochrome b-245, alpha polypeptide | Cyba |  |  | ↑ | ↑ |
nuclear factor I/X | Nfix |  |  | ↓ |  |
glutathione S-transferase, theta 2 | Gstt2 | ↓ |  |  |  |
Gtpase activating protein | Gyp1a1 | ↓ |  |  |  |
monoamine oxidase A | Maoa | ↓ |  |  |  |
Adaptation against existing ROS | Â | Â | Â | Â | |
FBJ osteosarcoma oncogene | Fos |  | ↑ | ↑ | ↑ |
superoxide dismutase 2 | Sod |  | ↑ | ↓ | ↓ |
glutathione S-transferase theta | Gstt |  | ↑ |  |  |
glutathione peroxidase 3 | Gpx |  |  |  | ↓ |
catalase | Cat |  |  |  | ↓ |
thioredoxin 2 | Txn2 |  |  |  | ↓ |