Table 2 Incidence of CVD events in relation to HbA1c level
% HbA1c | Men | Women | All | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Events/pts, n (/1000 py) | HR (95%CI) | p-value | Trend-p | Events/pts, n (/1000 py) | HR (95%CI) | p-value | Trend-p | Events/pts, n (/1000 py) | HR (95%CI) | p-value | Trend-p | |
CHD | <0.01 | <0.01 | <0.01 | |||||||||
<6.0 | 16/630 (5.6) | 1.0 | -- | 9/1481 (1.3) | 1.0 | -- | 25/2111 (2.6) | 1.0 | -- | |||
6.0-< 6.5 | 7/226 (7.1) | 1.2 (0.5-2.9) | 0.73 | 6/419 (3.2) | 2.1 (0.7-6.0) | 0.16 | 13/645 (4.5) | 1.5 (0.8-2.9) | 0.24 | |||
≥6.5 | 33/518 (14.7) | 2.3 (1.3-4.2) | <0.01 | 24/728 (7.2) | 4.9 (2.2-10.6) | <0.01 | 57/1246 (10.3) | 3.1 (1.9-5.0) | <0.01 | |||
Stroke (all) | 0.33 | 0.14 | 0.07 | |||||||||
<6.0 | 11/630 (3.9) | 1.0 | -- | 13/1481 (1.9) | 1.0 | -- | 24/2111 (2.5) | 1.0 | -- | |||
6.0-< 6.5 | 5/226 (5.0) | 1.1 (0.4-3.3) | 0.82 | 4/419 (2.1) | 1.0 (0.3-3.0) | 0.94 | 9/645 (3.1) | 1.1 (0.5-2.3) | 0.85 | |||
≥6.5 | 15/518 (6.5) | 1.5 (0.7-3.2) | 0.33 | 14/728 (4.2) | 1.8 (0.8-3.9) | 0.13 | 29/1246 (5.1) | 1.7 (1.0-2.9) | 0.07 | |||
CVD | <0.01 | <0.01 | <0.01 | |||||||||
<6.0 | 27/630 (9.6) | 1.0 | -- | 26/1481 (3.9) | 1.0 | -- | 53/2111 (5.6) | 1.0 | -- | |||
6.0-< 6.5 | 12/226 (12.2) | 1.2 (0.6-2.3) | 0.69 | 10/419 (5.4) | 1.2 (0.6-2.5) | 0.64 | 22/645 (7.7) | 1.2 (0.7-2.0) | 0.48 | |||
≥6.5 | 50/518 (22.9) | 2.1 (1.3-3.4) | <0.01 | 42/728 (12.8) | 2.9 (1.8-4.7) | <0.01 | 92/1246 (16.9) | 2.4 (1.7-3.4) | <0.01 | |||
Death (total) | 0.01 | 0.53 | 0.04 | |||||||||
<6.0 | 4/630 (1.4) | 1.0 | -- | 16/1481 (2.3) | 1.0 | -- | 20/2111 (2.1) | 1.0 | -- | |||
6.0-< 6.5 | 5/226 (4.9) | 3.4 (0.9-12.9) | 0.07 | 10/419 (5.2) | 2.2 (1.0-4.9) | 0.05 | 15/645 (5.1) | 2.3 (1.2-4.4) | 0.02 | |||
≥6.5 | 16/518 (6.7) | 4.1 (1.3-12.5) | 0.01 | 10/728 (2.9) | 1.2 (0.5-2.6) | 0.68 | 26/1246 (4.5) | 1.9 (1.0-3.4) | 0.04 | |||