Parameters | Control (n = 20) | DM (n = 17) | TSN (n = 17) | HOE140 (n = 18) |
---|---|---|---|---|
+LV dp/dt max | ||||
baseline | 4449.8 ± 190.2 | 4458.9 ± 318.7 | 4462.5 ± 253.5 | 4430.9 ± 455.8 |
11 w | 4528.2 ± 220.4 | 3678.6 ± 335.2* | 3759.8 ± 372.1* | 3699.3 ± 257.2* |
12 w | 4502.4 ± 254.1 | 3588.1 ± 454.0* | 4180.0 ± 747.9# | 3627.3 ± 199.0* ## |
-LV dp/dt max | ||||
baseline | 4359.3 ± 397.9 | 4464.7 ± 469.9 | 4215.2 ± 681.4 | 4127.3 ± 579.7 |
11 w | 4265.1 ± 438.2 | 3561.5 ± 440.6* | 3621.5 ± 582.4* | 3655.7 ± 492.8* |
12 w | 4366.7 ± 418.3 | 3389.9 ± 380.9* | 3878.4 ± 526.2* # | 3335.7 ± 499.0* ## |
LVESV (ml) | ||||
baseline | 0.25 ± 0.06 | 0.25 ± 0.08 | 0.25 ± 0.08 | 0.24 ± 0.08 |
11 w | 0.25 ± 0.05 | 0.36 ± 0.09* | 0.35 ± 0.05* | 0.35 ± 0.07* |
12 w | 0.26 ± 0.06 | 0.38 ± 0.08* | 0.31 ± 0.07* # | 0.37 ± 0.07* ## |
LVEDV (ml) | ||||
baseline | 1.08 ± 0.07 | 1.08 ± 0.08 | 1.07 ± 0.07 | 1.09 ± 0.07 |
11 w | 1.09 ± 0.08 | 1.21 ± 0.06* | 1.20 ± 0.09* | 1.19 ± 0.06* |
12 w | 1.09 ± 0.07 | 1.20 ± 0.08* | 1.14 ± 0.06* # | 1.17 ± 0.08* |
LVEF (%) | ||||
baseline | 76.5 ± 5.8 | 76.8 ± 7.3 | 76.0 ± 7.5 | 78.1 ± 7.1 |
11 w | 75.3 ± 5.2 | 68.2 ± 7.5* | 67.4 ± 7.8* | 67.1 ± 6.4* |
12 w | 75.5 ± 4.9 | 67.9 ± 6.0* | 72.1 ± 5.7# | 68.5 ± 5.4* ## |