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  1. The relationship between sodium glucose co-transporter 2 inhibitors (SGLT2i) and trimethylamine N-oxide (TMAO) following acute myocardial infarction (AMI) is not yet explored.

    Authors: Faisal Aziz, Norbert J. Tripolt, Peter N. Pferschy, Ewald Kolesnik, Harald Mangge, Pero Curcic, Markus Hermann, Andreas Meinitzer, Dirk von Lewinski and Harald Sourij
    Citation: Cardiovascular Diabetology 2023 22:184
    Content type: Research Published on:

  2. To investigate the association of variability in metabolic parameters such as total cholesterol concentrations (TC), uric acid (UA), body mass index (BMI), visceral adiposity index (VAI) and systolic blood pre...

    Authors: Ning Chen, Yu-Hong Liu, Li-Kun Hu, Lin-Lin Ma, Yu Zhang, Xi Chu, Jing Dong and Yu-Xiang Yan
    Citation: Cardiovascular Diabetology 2023 22:183
    Content type: Research Published on:

  3. Type 2 diabetes mellitus (T2DM) patients are at high risk of cardiovascular (CV) events. Factor XI (FXI) is associated with arterial thromboembolism, including myocardial infarction (MI), stroke, and CV morta...

    Authors: Elżbieta Paszek, Maciej Polak, Agata Hanna Bryk-Wiązania, Małgorzata Konieczyńska and Anetta Undas
    Citation: Cardiovascular Diabetology 2023 22:182
    Content type: Research Published on:

  4. Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes and are increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed t...

    Authors: Yulong Lan, Dan Wu, Zhiwei Cai, Yuancheng Xu, Xiong Ding, Weiqiang Wu, Shaocong Lan, Lan Chen, Zheng Guo, Lois Balmer, Xingang Li, Manshu Song, Shouling Wu, Jingli Gao, Wei Wang and Youren Chen
    Citation: Cardiovascular Diabetology 2023 22:181
    Content type: Research Published on:

  5. The triglyceride-glucose (TyG) index and the stress hyperglycaemia ratio (SHR) are both positively associated with cardiovascular (CV) risk in patients with coronary heart disease. However, the prognostic valu...

    Authors: Yanjun Song, Kongyong Cui, Min Yang, Chenxi Song, Dong Yin, Qiuting Dong, Ying Gao and Kefei Dou
    Citation: Cardiovascular Diabetology 2023 22:180
    Content type: Research Published on:

  6. Knowledge of the characteristics of first-ever cardiovascular events in type 1 diabetes may impact primary prevention strategies. This study describes the first-ever manifestation of cardiovascular disease (CV...

    Authors: Gabriel Giménez-Pérez, Clara Viñals, Manel Mata-Cases, Bogdan Vlacho, Jordi Real, Josep Franch-Nadal, Emilio Ortega and Dídac Mauricio
    Citation: Cardiovascular Diabetology 2023 22:179
    Content type: Research Published on:

  7. Type 2 diabetes mellitus (T2DM) and anemia are related to some cardiovascular diseases and can predict poor outcomes. Both of them can damage the heart in their own ways, but their combined effects have not be...

    Authors: Wen-Lei Qian, Zhi-Gang Yang, Rui Shi, Ying-Kun Guo, Han Fang, Meng-ting Shen and Yuan Li
    Citation: Cardiovascular Diabetology 2023 22:178
    Content type: Research Published on:

  8. Recent studies revealed that alterations in glucose and lipid metabolism in idiopathic pulmonary arterial hypertension (IPAH) are associated with disease severity and poor survival. However, data regarding the...

    Authors: Kamil Jonas, Marcin Kurzyna, Ewa Mroczek, Łukasz Chrzanowski, Tatiana Mularek-Kubzdela, Ilona Skoczylas, Piotr Błaszczak, Grzegorz Grześk, Katarzyna Mizia-Stec, Beata Kuśmierczyk, Karol Kamiński, Ewa Lewicka, Małgorzata Peregud-Pogorzelska, Michał Tomaszewski, Wojciech Jacheć, Zbigniew Gąsior…
    Citation: Cardiovascular Diabetology 2023 22:177
    Content type: Research Published on:

  9. The insulin-like growth factors (IGF) play a crucial role in regulating cellular proliferation, apoptosis, and key metabolic pathways. The ratio of IGF-1 to IGF binding protein-3 (IGFBP-3) is an important fact...

    Authors: Reza Mohebi, Yuxi Liu, Michael K. Hansen, Yshai Yavin, Naveed Sattar, Carol A. Pollock, Javed Butler, Meg Jardine, Serge Masson, Hiddo J. L. Heerspink and James L. Januzzi Jr
    Citation: Cardiovascular Diabetology 2023 22:176
    Content type: Research Published on:

  10. This ANAFIE Registry sub-analysis investigated 2-year outcomes and oral anticoagulant (OAC) use stratified by glycated hemoglobin (HbA1c) levels among Japanese patients aged ≥ 75 years with non-valvular atrial...

    Authors: Yasuo Terauchi, Hiroshi Inoue, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Ken Okumura, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura…
    Citation: Cardiovascular Diabetology 2023 22:175
    Content type: Research Published on:

  11. Type 2 diabetes (T2D) is expected to worsen the prognosis of inpatients with heart failure (HF) but the evidence from observational studies is inconsistent. We aimed to compare mortality outcomes and life expe...

    Authors: Dante Salvador Jr, Arjola Bano, Faina Wehrli, Valentina Gonzalez-Jaramillo, Markus Laimer, Lukas Hunziker and Taulant Muka
    Citation: Cardiovascular Diabetology 2023 22:174
    Content type: Research Published on:

  12. Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials treatment of elevated glucose levels with insulin did ...

    Authors: Sina Rhein, Julica Inderhees, Oliver Herrmann, Alaa Othman, Kimberly Begemann, Thomas Fleming, Peter P. Nawroth, Karel D. Klika, Rakad Isa, Inke R. König, Georg Royl and Markus Schwaninger
    Citation: Cardiovascular Diabetology 2023 22:173
    Content type: Research Published on:

  13. Higher chemokine C-X-C motif ligand 5 (CXCL5) level was observed in type 2 diabetes mellitus (DM) patients; however, its role in diabetic vasculopathy was not clarified. This study aimed to explore the impacts...

    Authors: Ching Chen, Liang-Yu Lin, Jaw-Wen Chen and Ting-Ting Chang
    Citation: Cardiovascular Diabetology 2023 22:172
    Content type: Research Published on:

    The Correction to this article has been published in Cardiovascular Diabetology 2023 22:196

  14. The triglyceride–glucose (TyG) index has been demonstrated to be a reliable surrogate marker of insulin resistance (IR) and an effective predictive index of cardiovascular (CV) disease risk. However, its long-...

    Authors: You Zhou, Chi Wang, Hebin Che, Liting Cheng, Di Zhu, Chongyou Rao, Qin Zhong, Zongren Li, Xiao Wang, Zisheng Wu and Kunlun He
    Citation: Cardiovascular Diabetology 2023 22:171
    Content type: Research Published on:

    The Correction to this article has been published in Cardiovascular Diabetology 2023 22:250

  15. The TyG index is an indicator of insulin resistance (IR), which is associated with the development and prognosis of cardiovascular disease. This study aimed to summarize the relationship between the TyG index ...

    Authors: Shichu Liang, Cui Wang, Jing Zhang, Zhiyue Liu, Yanlin Bai, Zhonglan Chen, He Huang and Yong He
    Citation: Cardiovascular Diabetology 2023 22:170
    Content type: Research Published on:

  16. Triglyceride-rich lipoproteins (TRL) and low-density lipoproteins (LDL) are associated positively whereas high-density lipoproteins (HDL) are associated inversely with the development of new-onset type 2 diabe...

    Authors: Arno R. Bourgonje, Margery A. Connelly, Harry van Goor, Peter R. van Dijk and Robin P. F. Dullaart
    Citation: Cardiovascular Diabetology 2023 22:169
    Content type: Research Published on:

  17. L-type Ca2+ channel CaV1.2 is essential for cardiomyocyte excitation, contraction and gene transcription in the heart, and abnormal functions of cardiac CaV1.2 channels are presented in diabetic cardiomyopathy. H...

    Authors: Pengpeng Li, Dongxia Qin, Tiange Chen, Wei Hou, Xinyu Song, Shumin Yin, Miaomiao Song, W.C. Hewith A. Fernando, Xiaojie Chen, Yu Sun and Juejin Wang
    Citation: Cardiovascular Diabetology 2023 22:168
    Content type: Research Published on:

  18. Glycemic variability plays an important role in the development of cardiovascular disease (CVD). This study aims to determine whether long-term visit-to-visit glycemic variability is associated with aortic sti...

    Authors: Qianhua Fang, Juan Shi, Jia Zhang, Ying Peng, Cong Liu, Xing Wei, Zhuomeng Hu, Lin Sun, Jie Hong, Weiqiong Gu, Weiqing Wang and Yifei Zhang
    Citation: Cardiovascular Diabetology 2023 22:167
    Content type: Research Published on:

  19. SGTL2-inhibitors are a cornerstone in the treatment of heart failure, but data on patients with acute myocardial infarction (AMI) is limited. The EMMY trial was the first to show a significant reduction in NTp...

    Authors: Martin Benedikt, Harald Mangge, Faisal Aziz, Pero Curcic, Sabine Pailer, Markus Herrmann, Ewald Kolesnik, Norbert J. Tripolt, Peter N. Pferschy, Markus Wallner, Andreas Zirlik, Harald Sourij and Dirk von Lewinski
    Citation: Cardiovascular Diabetology 2023 22:166
    Content type: Research Published on:

  20. Stress hyperglycemia was positively associated with poor prognosis in individuals with acute myocardial infarction (AMI). However, admission glucose and stress hyperglycemia ratio (SHR) may not be the best ind...

    Authors: Kongyong Cui, Rui Fu, Jingang Yang, Haiyan Xu, Dong Yin, Weihua Song, Hongjian Wang, Chenggang Zhu, Lei Feng, Zhifang Wang, Qingsheng Wang, Ye Lu, Kefei Dou and Yuejin Yang
    Citation: Cardiovascular Diabetology 2023 22:165
    Content type: Research Published on:

  21. In recent years, GLP-1 receptor agonists (GLP-1RA), and SGLT-2 inhibitors (SGLT-2i) have become available, which have become valuable additions to therapy for type 2 diabetes as they are associated with low ri...

    Authors: Cristina Panico, Benedetta Bonora, Antonella Camera, Nino Cristiano Chilelli, Giuliana Da Prato, Giuseppe Favacchio, Valeria Grancini, Veronica Resi, Maurizio Rondinelli, Emanuela Zarra and Basilio Pintaudi
    Citation: Cardiovascular Diabetology 2023 22:164
    Content type: Review Published on:

  22. This study aimed to examine the association between the incident onset of T2DM and 5- and 10-year risks of CVD and HF in people with IGT identified in primary care in South and West Auckland, New Zealand (NZ) ...

    Authors: Dahai Yu, Bingjie Qu, Uchechukwu Levi Osuagwu, Karen Pickering, John Baker, Richard Cutfield MBChB, Yamei Cai, Brandon J Orr-Walker, Gerhard Sundborn, Zhanzheng Zhao and David Simmons
    Citation: Cardiovascular Diabetology 2023 22:163
    Content type: Research Published on:

  24. Insulin resistance (IR) has been confirmed that getting involved in the pathophysiological process of cardiovascular diseases (CVD). Recently, increasing evidence suggests metabolic score for insulin resistanc...

    Authors: Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng and Xianliang Zhou
    Citation: Cardiovascular Diabetology 2023 22:161
    Content type: Research Published on:

  25. Numerous studies have investigated the potential association of sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) with an increased risk of lower limb amputations (LLAs), but have produced conflicting resu...

    Authors: Nikki C. C. Werkman, Johanna H. M. Driessen, Coen D. A. Stehouwer, Peter Vestergaard, Nicolaas C. Schaper, Joop P. van den Bergh and Johannes T. H. Nielen
    Citation: Cardiovascular Diabetology 2023 22:160
    Content type: Research Published on:

  26. Authors: Ki‑Bum Won, Seung‑Ho Hur, Yun‑Kyeong Cho, Hyuck‑Jun Yoon, Chang‑Wook Nam, Kwon‑Bae Kim, Jang‑Ho Bae, Dong‑Ju Choi, Young‑Keun Ahn, Jong‑Seon Park, Hyo‑Soo Kim, Rak‑Kyeong Choi, Donghoon Choi, Joon‑Hong Kim, Kyoo‑Rok Han, Hun‑Sik Park…
    Citation: Cardiovascular Diabetology 2023 22:159
    Content type: Correction Published on:

    The original article was published in Cardiovascular Diabetology 2015 14:141

  27. Diabetic cardiovascular autonomic neuropathy (CAN) and distal symmetrical polyneuropathy (DSPN) are severe diabetic complications. Collagen type VI (COL6) and III (COL3) have been associated with nerve functio...

    Authors: Christian S. Hansen, Daniel G. K. Rasmussen, Tine W. Hansen, Signe Holm Nielsen, Simone Theilade, Morten A. Karsdal, Federica Genovese and Peter Rossing
    Citation: Cardiovascular Diabetology 2023 22:158
    Content type: Research Published on:

  28. Although there is numerous evidence on the epidemiological risk factors for insulin resistance (IR)-related metabolic diseases, there is still insufficient evidence to explore the non-linear association of Ath...

    Authors: Bei Yin, Zihong Wu, Yaqing Xia, Shunqiang Xiao, Lingling Chen and Yousheng Li
    Citation: Cardiovascular Diabetology 2023 22:157
    Content type: Research Published on:

  29. The association of the triglyceride-glucose (TyG) index with severe consciousness disturbance and in-hospital mortality in patients with cerebrovascular disease in the intensive care unit (ICU) is unclear. Thi...

    Authors: Ting Chen, Yuan Qian and Xingli Deng
    Citation: Cardiovascular Diabetology 2023 22:156
    Content type: Research Published on:

  31. Type 2 diabetes mellitus (T2DM) frequently coexists with obstructive coronary artery disease (OCAD), which are at increased risk for cardiovascular morbidity and mortality. This study aimed to investigate the ...

    Authors: Jin Wang, Zhi-Gang Yang, Ying-Kun Guo, Yu Jiang, Wei-Feng Yan, Wen-Lei Qian, Han Fang, Chen-Yan Min and Yuan Li
    Citation: Cardiovascular Diabetology 2023 22:154
    Content type: Research Published on:

  32. Recent large clinical trials have demonstrated cardiovascular benefits of similar overall magnitude for sodium–glucose cotransporter-2 inhibitor (SGLT-2i) and glucagon-like peptide-1 receptor agonist (GLP-1RA)...

    Authors: Minji Sohn, Johannes W. Dietrich, Michael A. Nauck and Soo Lim
    Citation: Cardiovascular Diabetology 2023 22:153
    Content type: Research Published on:

  33. The cardiovascular (CV) benefits of sodium-glucose transport protein 2 inhibitors have been attributed, in part, to cardiac reverse remodelling. The EMPA-HEART CardioLink-6 study reported that sodium-glucose c...

    Authors: Pankaj Puar, Makoto Hibino, C. David Mazer, Andrew T. Yan, Arjun K. Pandey, Adrian Quan, Hwee Teoh, David A. Hess, Raj Verma, Kim A. Connelly and Subodh Verma
    Citation: Cardiovascular Diabetology 2023 22:152
    Content type: Research Published on:

  34. This study aimed to investigate the impact of lipoprotein(a) [Lp(a)] levels on the prognosis of Chinese patients with ST-segment elevation myocardial infarction (STEMI), and to explore if the impact may differ...

    Authors: Nan Li, Jinying Zhou, Runzhen Chen, Xiaoxiao Zhao, Jiannan Li, Peng Zhou, Chen Liu, Yi Chen, Ying Wang, Li Song, Shaodi Yan, Hanjun Zhao and Hongbing Yan
    Citation: Cardiovascular Diabetology 2023 22:151
    Content type: Research Published on:

  35. The potential predictive significance of atherogenic index of plasma (AIP) for cardiovascular outcomes in patients with acute coronary syndrome (ACS) and who have undergone percutaneous coronary intervention (...

    Authors: Yue Wang, Shen Wang, Shuaifeng Sun, Fadong Li, Wenxin Zhao, Hongxia Yang and Xiaofan Wu
    Citation: Cardiovascular Diabetology 2023 22:150
    Content type: Research Published on:

  36. Elevated triglyceride-glucose (TyG) index and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are independently associated with increased risk of major adverse cardio-cerebral events (MACCEs) in diabetic...

    Authors: Man Wang, Li Zhou, Wen Su, Wenxi Dang, Hongwei Li and Hui Chen
    Citation: Cardiovascular Diabetology 2023 22:149
    Content type: Research Published on:

  37. Diabetic foot is a significant cause of morbidity in diabetic patients, with a rate that is approximately twice that of patients without foot ulcers. “Metabolic memory” represents the epigenetic changes induce...

    Authors: Alessandro Del Cuore, Rosaria Maria Pipitone, Alessandra Casuccio, Marco Maria Mazzola, Maria Grazia Puleo, Gaetano Pacinella, Renata Riolo, Carlo Maida, Tiziana Di Chiara, Domenico Di Raimondo, Rossella Zito, Giulia Lupo, Luisa Agnello, Gabriele Di Maria, Marcello Ciaccio, Stefania Grimaudo…
    Citation: Cardiovascular Diabetology 2023 22:148
    Content type: Research Published on:

  38. Impaired kidney function and albuminuria are associated with increased risk of heart failure (HF) in patients with type 2 diabetes (T2D). We investigated whether rapid kidney function decline over time is an a...

    Authors: Carlos Roberto Bueno Junior, Arjola Bano, Yaling Tang, Xiuqin Sun, Alex Abate, Elizabeth Hall, Joanna Mitri, Mario Luca Morieri, Hetal Shah and Alessandro Doria
    Citation: Cardiovascular Diabetology 2023 22:131
    Content type: Research Published on:

  39. Type 2 diabetes is associated with an increased risk of developing cardiovascular events. Previous studies have reported that advanced glycation end products (AGEs) were related to cardiovascular events in typ...

    Authors: Tomoka Nakamura, Tetsuro Tsujimoto, Kazuki Yasuda, Kohjiro Ueki and Hiroshi Kajio
    Citation: Cardiovascular Diabetology 2023 22:147
    Content type: Research Published on:

  40. The occurrence and development of coronary heart disease (CHD) are closely linked to fluctuations in blood glucose levels. While the efficacy of intensified treatment guided by HbA1c levels remains uncertain f...

    Authors: Jingyang Chen, Dong Yin and Kefei Dou
    Citation: Cardiovascular Diabetology 2023 22:146
    Content type: Review Published on:

  42. The nuclear receptor corepressor 1 (NCOR1) plays an important role in the regulation of gene expression in immunometabolic conditions by connecting chromatin-modifying enzymes, coregulators and transcription f...

    Authors: Martin Geiger, Sara Oppi, Stefanie Nusser-Stein, Sarah Costantino, Shafeeq Ahmed Mohammed, Era Gorica, Joanne A. Hoogerland, Christian M. Matter, Ana T. Guillaumon, Frank Ruschitzka, Francesco Paneni, Maaike H. Oosterveer and Sokrates Stein
    Citation: Cardiovascular Diabetology 2023 22:144
    Content type: Research Published on:

  43. This study aimed to assess the long-term effects of tofogliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression and major clinical parameters in patients with type 2 diabe...

    Authors: Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Akira Kurozumi, Masahiro Hatazaki, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi…
    Citation: Cardiovascular Diabetology 2023 22:143
    Content type: Research Published on:

  44. Biomarker of insulin resistance, namely triglyceride-glucose index, is potentially useful in identifying critically ill patients at high risk of hospital death. However, the TyG index might have variations ove...

    Authors: Long Cheng, Feng Zhang, Wenjing Xue, Peng Yu, Xiaoyan Wang, Hairong Wang, Jun Wang, Tianyang Hu, Hui Gong and Li Lin
    Citation: Cardiovascular Diabetology 2023 22:142
    Content type: Research Published on:

  45. Metabolic Syndrome (MetS) is characterized by risk factors such as abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), hypertension, and hyperglycemia, which contribute t...

    Authors: Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone, Shixiang Yu, Makoto Harada, Ann-Kristin Henning, Nele Friedrich, Martin Bahls, Marcus Dörr, Matthias Nauck, Henry Völzke, Georg Homuth, Hans J. Grabe, Cornelia Prehn…
    Citation: Cardiovascular Diabetology 2023 22:141
    Content type: Research Published on:

  46. Cardiovascular mortality and the impact of cardiac risk factors in advanced chronic kidney disease (CKD) remain poorly investigated. We examined the risk of cardiovascular mortality in patients with advanced C...

    Authors: Dea Haagensen Kofod, Nicholas Carlson, Ellen Freese Ballegaard, Thomas Peter Almdal, Christian Torp-Pedersen, Gunnar Gislason, Jesper Hastrup Svendsen, Bo Feldt-Rasmussen and Mads Hornum
    Citation: Cardiovascular Diabetology 2023 22:140
    Content type: Research Published on:

  47. An accurate prediction of survival prognosis is beneficial to guide clinical decision-making. This prospective study aimed to develop a model to predict one-year mortality among older patients with coronary ar...

    Authors: Yan Li, Lixun Guan, Chaoxue Ning, Pei Zhang, Yali Zhao, Qiong Liu, Ping Ping and Shihui Fu
    Citation: Cardiovascular Diabetology 2023 22:139
    Content type: Research Published on:

  48. The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG inde...

    Authors: Weimin Cai, Jun Xu, Xiao Wu, Zhuoyan Chen, Liuwei Zeng, Xian Song, Yuan Zeng and Fujun Yu
    Citation: Cardiovascular Diabetology 2023 22:138
    Content type: Research Published on:

  49. Visceral obesity is associated with high cardiovascular events risk in type 2 diabetes mellitus (T2DM). Whether normal-weight visceral obesity will pose a higher atherosclerotic cardiovascular disease (ASCVD) ...

    Authors: Jia Zheng, Ye Hu, Hanwen Xu, Yu Lei, Jieji Zhang, Qidong Zheng, Li Li, Weiping Tu, Riqiu Chen, Qiongyao Guo, Xunxiong Zang, Qiaoying You, Zhiyong Xu, Qiang Zhou and Xiaohong Wu
    Citation: Cardiovascular Diabetology 2023 22:137
    Content type: Research Published on:
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