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  1. Recent clinical trials reported conflicting results on the reduction of new-onset diabetes using RAS blocking agents. Therefore the role of these agents in preventing diabetes is still not well defined. Ramipr...

    Authors: Walter Zidek, Joachim Schrader, Stephan Lüders, Stephan Matthaei, Christoph Hasslacher, Joachim Hoyer, Peter Bramlage, Claus-Dieter Sturm and W Dieter Paar

    Citation: Cardiovascular Diabetology 2008 7:22

    Content type: Original investigation

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  2. There is currently much interest in encouraging individuals to increase physical activity in order to reduce CVD risk. This study has been designed to determine if personalised CVD risk appreciation can increa...

    Authors: Hermione C Price, Lynne Tucker, Simon J Griffin and Rury R Holman

    Citation: Cardiovascular Diabetology 2008 7:21

    Content type: Study protocol

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  3. The metabolic deregulation associated with diabetes mellitus (DM) causes secondary pathophysiologic changes in multiple organ systems. Endothelial injury is induced by oxidative stress (OS) and inflammation. W...

    Authors: Raymond Farah, Revital Shurtz-Swirski and Olga Lapin

    Citation: Cardiovascular Diabetology 2008 7:20

    Content type: Original investigation

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  4. Epidemiologic studies have suggested that hypertriglyceridemia and insulin resistance are related to the development of colon cancer. Nuclear peroxisome proliferator-activated receptors (PPAR), which play a ce...

    Authors: Alexander Tenenbaum, Valentina Boyko, Enrique Z Fisman, Ilan Goldenberg, Yehuda Adler, Micha S Feinberg, Michael Motro, David Tanne, Joseph Shemesh, Ehud Schwammenthal and Solomon Behar

    Citation: Cardiovascular Diabetology 2008 7:18

    Content type: Original investigation

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  5. The large clinical trials proved that Basal-Bolus (BB) insulin therapy was effective in the prevention of diabetic complications and their progression. However, BB therapy needs multiple insulin injections per...

    Authors: Yumi Miyashita, Rimei Nishimura, Masami Nemoto, Toru Matsudaira, Hideaki Kurata, Tamotsu Yokota, Kuninobu Yokota, Katsuyoshi Tojo, Kazunori Utsunomiya and Naoko Tajima

    Citation: Cardiovascular Diabetology 2008 7:16

    Content type: Original investigation

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  6. In comparison to the well established changes in compliance that occur at the large vessel level in diabetes, much less is known about the changes in compliance of the cardiovascular system at the end-organ le...

    Authors: Richard J MacIsaac, Merlin C Thomas, Sianna Panagiotopoulos, Trudy J Smith, Huming Hao, D Geoffrey Matthews, George Jerums, Louise M Burrell and Piyush M Srivastava

    Citation: Cardiovascular Diabetology 2008 7:15

    Content type: Original investigation

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  7. Epidemiological studies have revealed a relationship between early growth restriction and the subsequent development of insulin resistance and type 2 diabetes. Ligation of the uterine arteries in rats mimics u...

    Authors: Daniela Germani, Antonella Puglianiello and Stefano Cianfarani

    Citation: Cardiovascular Diabetology 2008 7:14

    Content type: Original investigation

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  8. Diabetes has negative, and exercise training positive, effects on the skeletal muscle vasculature, but the mechanisms are not yet fully understood. In the present experiment the effects of running exercise on ...

    Authors: Riikka Kivelä, Mika Silvennoinen, Maarit Lehti, Sanni Jalava, Veikko Vihko and Heikki Kainulainen

    Citation: Cardiovascular Diabetology 2008 7:13

    Content type: Original investigation

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  9. Hypertension and type 2 diabetes are common co-morbidities. Preliminary studies suggest that thiazolidinediones reduce blood pressure (BP). We therefore used ambulatory BP to quantify BP lowering at 6–12 month...

    Authors: Michel Komajda, Paula Curtis, Markolf Hanefeld, Henning Beck-Nielsen, Stuart J Pocock, Andrew Zambanini, Nigel P Jones, Ramon Gomis and Philip D Home

    Citation: Cardiovascular Diabetology 2008 7:10

    Content type: Original investigation

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  10. There are no risk scores available for predicting heart failure in Type 2 diabetes mellitus (T2DM). Based on the Hong Kong Diabetes Registry, this study aimed to develop and validate a risk score for predictin...

    Authors: Xilin Yang, Ronald C Ma, Wing-Yee So, Alice P Kong, Gary T Ko, Chun-Shun Ho, Christopher W Lam, Clive S Cockram, Peter C Tong and Juliana C Chan

    Citation: Cardiovascular Diabetology 2008 7:9

    Content type: Original investigation

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  11. An authentic survey of the transcript-level response of the diabetic endothelium in vivo is key to understanding diabetic cardiovascular complications such as accelerated atherosclerosis and endothelial dysfun...

    Authors: J Gregory Maresh and Ralph V Shohet

    Citation: Cardiovascular Diabetology 2008 7:8

    Content type: Original investigation

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  12. The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this...

    Authors: Salam A Al-Attar, Rebecca L Pollex, Matthew R Ban, T Kue Young, Peter Bjerregaard, Sonia S Anand, Salim Yusuf, Bernard Zinman, Stewart B Harris, Anthony JG Hanley, Philip W Connelly, Murray W Huff and Robert A Hegele

    Citation: Cardiovascular Diabetology 2008 7:5

    Content type: Original investigation

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  13. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported to be as closely correlated with insulin resistance as is the fasting serum insulin concentration (FSI), and therefor...

    Authors: Chaoyang Li, Earl S Ford, Yuan-Xiang Meng, Ali H Mokdad and Gerald M Reaven

    Citation: Cardiovascular Diabetology 2008 7:4

    Content type: Original investigation

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  14. Thiazolidinediones exert anti-inflammatory and anti-oxidative roles and attenuate atherosclerosis by mechanisms partially independent of their metabolizing actions. High doses of angiotensin type 1 receptor (AT1R...

    Authors: Y Hernandez-Trujillo, F Rodriguez-Esparragon, A Macias-Reyes, A Caballero-Hidalgo and Jose C Rodriguez-Perez

    Citation: Cardiovascular Diabetology 2008 7:3

    Content type: Original investigation

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  15. Activation of the diacylglycerol (DAG)-protein kinase C (PKC) pathway has been implicated in the pathogenesis of a number of diabetic complications. Diacylglycerol kinase (DGK) converts DAG to phosphatidic aci...

    Authors: Olga Bilim, Yasuchika Takeishi, Tatsuro Kitahara, Takanori Arimoto, Takeshi Niizeki, Toshiki Sasaki, Kaoru Goto and Isao Kubota

    Citation: Cardiovascular Diabetology 2008 7:2

    Content type: Original investigation

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  16. Aortic distensibility (AD) is a marker of the elastic properties of the aorta. Reduction of AD occurs early in subjects with type 2 diabetes mellitus (T2DM) and it is associated with subclinical generalized at...

    Authors: Nicholas Tentolouris, Athanasia Papazafiropoulou, Ioannis Moyssakis, Stavros Liatis, Despoina Perrea, Maria Kostakis and Nicholas Katsilambros

    Citation: Cardiovascular Diabetology 2008 7:1

    Content type: Original investigation

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  17. Intensive insulin therapy to maintain normoglycemia after cardiac surgery reduces morbidity and mortality. We investigated the magnitude and duration of hyperglycemia caused by dexamethasone administered after...

    Authors: Mathijs Vogelzang, Miriam Hoekstra, José T Drost, Marcel Janse, Iwan CC van der Horst, Piet W Boonstra, Felix Zijlstra, Bert G Loef and Maarten WN Nijsten

    Citation: Cardiovascular Diabetology 2007 6:39

    Content type: Original investigation

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  18. The aim of the present study was to investigate the relationship between speed during maximum exercise test (ET) and oxygen consumption (VO2) in control and STZ-diabetic rats, in order to provide a useful method ...

    Authors: Bruno Rodrigues, Diego M Figueroa, Cristiano T Mostarda, Marcelo V Heeren, Maria-Cláudia Irigoyen and Kátia De Angelis

    Citation: Cardiovascular Diabetology 2007 6:38

    Content type: Methodology

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  19. Glycated haemoglobin (HbA1c), blood pressure and body mass index (BMI) are risk factors for albuminuria, the latter in turn can lead to hyperlipidaemia. We used novel statistical analyses to examine how albuminur...

    Authors: Xilin Yang, Ronald C Ma, Wing-Yee So, Gary T Ko, Alice P Kong, Christopher W Lam, Chun-Shun Ho, Clive S Cockram, Vivian C Wong, Peter C Tong and Juliana C Chan

    Citation: Cardiovascular Diabetology 2007 6:37

    Content type: Original investigation

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  20. A number of intervention studies have shown that therapy with angiotensin receptor blockers, such as irbesartan, can improve metabolic parameters and reduce the incidence of diabetes mellitus. It is unknown wh...

    Authors: Klaus G Parhofer, Felix Münzel and Michael Krekler

    Citation: Cardiovascular Diabetology 2007 6:36

    Content type: Original investigation

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  21. We have reviewed the impact of the ubiquitin proteasome system (UPS) on atherosclerosis progression of diabetic patients. A puzzle of many pieces of evidence suggests that UPS, in addition to its role in the r...

    Authors: Raffaele Marfella, Michele D' Amico, Clara Di Filippo, Mario Siniscalchi, Ferdinando Carlo sasso, Franca Ferraraccio, Francesco Rossi and Giuseppe Paolisso

    Citation: Cardiovascular Diabetology 2007 6:35

    Content type: Hypothesis

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  22. Congenital heart defects are frequently observed in infants of diabetic mothers, but the molecular basis of the defects remains obscure. Thus, the present study was performed to gain some insights into the mol...

    Authors: Srinivasan Dinesh Kumar, S Thameem Dheen and Samuel Sam Wah Tay

    Citation: Cardiovascular Diabetology 2007 6:34

    Content type: Original investigation

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  23. Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes. Thiazolidinediones (TZDs) inhibit v...

    Authors: Peter J Little, Narin Osman, Stephanie T de Dios, Nelly Cemerlang, Mandy Ballinger and Julie Nigro

    Citation: Cardiovascular Diabetology 2007 6:33

    Content type: Original investigation

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  24. Impaired glucose regulation (IGR) is associated with detrimental cardiovascular outcomes such as cardiovascular disease risk factors (CVD risk factors) or intima-media thickness (IMT). Our aim was to examine w...

    Authors: David Faeh, Julita William, Patrick Yerly, Fred Paccaud and Pascal Bovet

    Citation: Cardiovascular Diabetology 2007 6:32

    Content type: Original investigation

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  25. Because of previously reported ethnic differences in determinants and markers of obesity and related metabolic disorders, we sought to investigate circulating levels of adiponectin and their correlates in a su...

    Authors: Eugène Sobngwi, Valery Effoe, Philippe Boudou, Dieudonné Njamen, Jean-François Gautier and Jean-Claude Mbanya

    Citation: Cardiovascular Diabetology 2007 6:31

    Content type: Original investigation

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  26. Recent studies have suggested that diabetes mellitus (DM) may cause left ventricular (LV) dysfunction directly resulting in increased susceptibility to heart failure. Using pinhole collimators and advances in ...

    Authors: Bernard Cosyns, Steven Droogmans, Caroline Weytjens, Tony Lahoutte, Guy Van Camp, Danny Schoors and Philippe R Franken

    Citation: Cardiovascular Diabetology 2007 6:30

    Content type: Original investigation

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  27. Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation ...

    Authors: Muammer Karadeniz, Mehmet Erdogan, Afig Berdeli, Sadik Tamsel, Fusun Saygili and Candeger Yilmaz

    Citation: Cardiovascular Diabetology 2007 6:29

    Content type: Original investigation

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  28. The Study of Micardis (telmisartan) in Overweight/Obese patients with Type 2 diabetes and Hypertension (SMOOTH) compared hydrochlorothiazide (HCTZ) plus telmisartan or valsartan fixed-dose combination therapie...

    Authors: Arya M Sharma, Jaime Davidson, Stephen Koval and Yves Lacourcière

    Citation: Cardiovascular Diabetology 2007 6:28

    Content type: Original investigation

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  29. Since visceral fat tissue is known to release various inflammatory and anti-inflammatory cytokines, abdominal obesity may play a key role in the inflammation associated with metabolic syndrome (MetS). However,...

    Authors: Makoto Nishida, Toshiki Moriyama, Yoshiro Sugita and Keiko Yamauchi-Takihara

    Citation: Cardiovascular Diabetology 2007 6:27

    Content type: Original investigation

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  30. A beneficial effect on glucose metabolism is reported with angiotensin receptor blocker (ARB) treatment of hypertension. The effect on blood glucose level during the course of treatment with ARBs in clinical c...

    Authors: Noboru Kitamura, Yasuo Takahashi, Shuukoh Yamadate and Satoshi Asai

    Citation: Cardiovascular Diabetology 2007 6:26

    Content type: Original investigation

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  31. Lack of treatment initiation or intensification might explain why some patients with type 2 diabetes do not reach target goals. The objective is to assess trends in risk factor treatment, and identify determin...

    Authors: Jacoba P Greving, Petra Denig, Dick de Zeeuw, Henk JG Bilo and Flora M Haaijer-Ruskamp

    Citation: Cardiovascular Diabetology 2007 6:25

    Content type: Original investigation

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  32. Diabetes Mellitus (DM) is a major public health problem in the UAE with a prevalence rate reaching 24% in national citizens and 17.4% in expatriates. The aim of this study was to determine the prevalence and r...

    Authors: Fatma Al-Maskari, Mohammed El-Sadig and John N Norman

    Citation: Cardiovascular Diabetology 2007 6:24

    Content type: Original investigation

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  33. Although oxidative stress by accumulation of reactive oxygen species (ROS) in diabetes has become evident, it remains unclear what genes, involved in redox balance, would determine susceptibility for developme...

    Authors: Masami Nemoto, Rimei Nishimura, Takashi Sasaki, Yoshito Hiki, Yumi Miyashita, Makiko Nishioka, Kei Fujimoto, Toru Sakuma, Toya Ohashi, Kunihiko Fukuda, Yoshikatsu Eto and Naoko Tajima

    Citation: Cardiovascular Diabetology 2007 6:23

    Content type: Original investigation

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  34. The metabolic syndrome (MetSyn) places individuals at increased risk for type 2 diabetes and cardiovascular disease. Prevalence rates of the population of the MetSyn are still scarce. Moreover, the impact of d...

    Authors: Susanne Moebus, Jens Ulrich Hanisch, Pamela Aidelsburger, Peter Bramlage, Jürgen Wasem and Karl-Heinz Jöckel

    Citation: Cardiovascular Diabetology 2007 6:22

    Content type: Original investigation

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  35. Type 2 diabetes is characterised by increased plasma concentrations of pro-inflammatory cytokines [such as tumour necrosis factor – alpha; TNF-α] and soluble forms of adhesion molecules involved in leukocyte –...

    Authors: Joanna R Worley, David A Hughes, Nicoletta Dozio, Jelena Gavrilovic and Mike J Sampson

    Citation: Cardiovascular Diabetology 2007 6:21

    Content type: Original investigation

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  36. The association between TGF-β1 levels and long-term major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) is controversial. No study specifically addressed patients with CAD...

    Authors: Beatriz D Schaan, Alexandre S Quadros, Rogério Sarmento-Leite, Giuseppe De Lucca Jr, Alexandra Bender and Marcello Bertoluci

    Citation: Cardiovascular Diabetology 2007 6:19

    Content type: Original investigation

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  37. Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in pre-diabetic, (IFG and IGT), ...

    Authors: Nasser M Al-Daghri, Omar S Al-Attas, Khalid Al-Rubeaan, Mehad Mohieldin, Mohammad Al-Katari, Alan F Jones and Sudhesh Kumar

    Citation: Cardiovascular Diabetology 2007 6:18

    Content type: Original investigation

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  38. Sensitivity to ischemia and its underlying mechanisms in type 2 diabetic hearts are still largely unknown. Especially, correlation between reperfusion induced ventricular arrhythmia and changes in intracellula...

    Authors: Ryuko Anzawa, Shingo Seki, Kazuaki Horikoshi, Masayuki Taniguchi and Seibu Mochizuki

    Citation: Cardiovascular Diabetology 2007 6:17

    Content type: Original investigation

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  39. Observational clinical studies have shown that patients with diabetes have less favorable results after percutaneous coronary intervention compared with the non-diabetic counterparts, but its mechanism remains...

    Authors: Qi Zhang, Lin Lu, LiJin Pu, RuiYan Zhang, Jie Shen, ZhengBing Zhu, Jian Hu, ZhenKun Yang, QiuJin Chen and WeiFeng Shen

    Citation: Cardiovascular Diabetology 2007 6:16

    Content type: Original investigation

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  40. The atheroprotective effects of systemic delivery of either apolipoprotein A-I (wtApoA-I) or the naturally occurring mutant ApoA-I Milano (ApoA-IM) have been established in animal and human trials, but direct com...

    Authors: Corinna Lebherz, Julio Sanmiguel, James M Wilson and Daniel J Rader

    Citation: Cardiovascular Diabetology 2007 6:15

    Content type: Original investigation

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  41. Because cardiomyopathy is the leading cause of death in diabetic patients, the determination of myocardial function in diabetes mellitus is essential. In the present study, we provide an integrated approach, u...

    Authors: Rogério Wichi, Christiane Malfitano, Kaleizu Rosa, Silvia B De Souza, Vera Salemi, Cristiano Mostarda, Kátia De Angelis and Maria Claudia Irigoyen

    Citation: Cardiovascular Diabetology 2007 6:14

    Content type: Original investigation

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  42. One of the major controversies surrounding the metabolic syndrome (MetS) in type 2 diabetes is whether its single components act synergistically as risk factors for atherosclerotic vascular disease (AVD). We a...

    Authors: Markolf Hanefeld, Carsta Koehler, Silvina Gallo, Inge Benke and Petra Ott

    Citation: Cardiovascular Diabetology 2007 6:13

    Content type: Original investigation

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  43. The metabolic syndrome is a cluster of cardiovascular risk factors leading to an increased risk for the subsequent development of diabetes and cardiovascular morbidity and mortality. Blocking the renin-angiote...

    Authors: Ulrich Kintscher, Peter Bramlage, W Dieter Paar, Martin Thoenes and Thomas Unger

    Citation: Cardiovascular Diabetology 2007 6:12

    Content type: Original investigation

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