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  1. We investigated whether macronutrient composition of energy-restricted diets influences the efficacy of a telemedically guided weight loss program.

    Authors: Sabine Frisch, Armin Zittermann, Heiner K Berthold, Christian Götting, Joachim Kuhn, Knut Kleesiek, Peter Stehle and Heinrich Körtke

    Citation: Cardiovascular Diabetology 2009 8:36

    Content type: Original investigation

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  2. Our aim was to compare the effects of a Paleolithic ('Old Stone Age') diet and a diabetes diet as generally recommended on risk factors for cardiovascular disease in patients with type 2 diabetes not treated w...

    Authors: Tommy Jönsson, Yvonne Granfeldt, Bo Ahrén, Ulla-Carin Branell, Gunvor Pålsson, Anita Hansson, Margareta Söderström and Staffan Lindeberg

    Citation: Cardiovascular Diabetology 2009 8:35

    Content type: Original investigation

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  3. Few studies have assessed secular changes in the levels of cardiovascular risk factors (CV-RF) in populations of low or middle income countries. The systematic collection of a broad set of both traditional and...

    Authors: Pascal Bovet, Sarah Romain, Conrad Shamlaye, Shanti Mendis, Roger Darioli, Walter Riesen, Luc Tappy and Fred Paccaud

    Citation: Cardiovascular Diabetology 2009 8:34

    Content type: Original investigation

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  4. Both obesity and type 2 diabetes are among the risk factors for breast cancer development. Combined effect of these metabolic abnormalities on breast cancer risk however, has not been examined in premenopausal...

    Authors: Majed S Alokail, Nasser M Al-Daghri, Omar S Al-Attas and Tajamul Hussain

    Citation: Cardiovascular Diabetology 2009 8:33

    Content type: Original investigation

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  5. In streptozotocin-injected rats (STZ-rats), we previously demonstrated a role for angiotensin II (AT-II) in cardiac remodelling and insulin resistance partially counteracted by in vivo treatment with losartan, an...

    Authors: Paola Failli, Chiara Alfarano, Sergio Franchi-Micheli, Edoardo Mannucci, Elisabetta Cerbai, Alessandro Mugelli and Laura Raimondi

    Citation: Cardiovascular Diabetology 2009 8:32

    Content type: Original investigation

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  6. A variant in the promoter of the human uncoupling protein 2 (UCP2) gene, the G-866A polymorphism, has been associated with future risk of coronary heart disease events, in those devoid of traditional risk fact...

    Authors: Barry R Palmer, Courtney L Devereaux, Sukhbir S Dhamrait, Tessa J Mocatta, Anna P Pilbrow, Chris M Frampton, Lorraine Skelton, Tim G Yandle, Christine C Winterbourn, A Mark Richards, Hugh E Montgomery and Vicky A Cameron

    Citation: Cardiovascular Diabetology 2009 8:31

    Content type: Original investigation

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  7. The study examined changes in and relationship between body mass index (BMI), leptin and adiponectin levels over a 3-year period in a pediatric population-based cohort.

    Authors: Rimei Nishimura, Hironari Sano, Toru Matsudaira, Aya Morimoto, Yumi Miyashita, Takako Shirasawa, Akatsuki Kokaze and Naoko Tajima

    Citation: Cardiovascular Diabetology 2009 8:30

    Content type: Original investigation

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  8. We have recently demonstrated in man that a functional allelic polymorphism in the Haptoglobin (Hp) gene plays a major role in determining survival and congestive heart failure after myocardial infarction (MI)...

    Authors: Roy Asaf, Shany Blum, Ariel Roguin, Shiri Kalet-Litman, Jad Kheir, Avi Frisch, Rachel Miller-Lotan and Andrew P Levy

    Citation: Cardiovascular Diabetology 2009 8:29

    Content type: Original investigation

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  9. Type 2 diabetes mellitus (T2DM) is a genetically heterogeneous disease, hepatocyte nuclear factor-1 homeobox A (HNF1A) single-nucleotide polymorphisms (SNPs) playing a minor role in its pathogenesis. HNF1A is a f...

    Authors: Fernando MA Giuffrida, Gilberto K Furuzawa, Teresa S Kasamatsu, Marcos M Oliveira, Andre F Reis and Sergio A Dib

    Citation: Cardiovascular Diabetology 2009 8:28

    Content type: Original investigation

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  10. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of endothelial nitric oxide synthase (eNOS) that is associated with endothelial dysfunction, and is a risk marker for cardiovascular disease, a sig...

    Authors: Latika Sibal, Sharad C Agarwal, Edzard Schwedhelm, Nicole Lüneburg, Rainer H Böger and Philip D Home

    Citation: Cardiovascular Diabetology 2009 8:27

    Content type: Original investigation

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  11. The benefit of statins for prevention of cardiovascular events in type 2 diabetes is established, but a gap exists between guideline recommendations and clinical practice. The aim of the study was to identify ...

    Authors: Heiner K Berthold, Ioanna Gouni-Berthold, Michael Böhm, Wilhelm Krone and Kurt P Bestehorn

    Citation: Cardiovascular Diabetology 2009 8:25

    Content type: Original investigation

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  12. Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted ...

    Authors: Alberto O Chavez, Amalia Gastaldelli, Rodolfo Guardado-Mendoza, Juan C Lopez-Alvarenga, M Michelle Leland, M Elizabeth Tejero, GianPio Sorice, Francesca Casiraghi, Alberto Davalli, Raúl A Bastarrachea, Anthony G Comuzzie, Ralph A DeFronzo and Franco Folli

    Citation: Cardiovascular Diabetology 2009 8:22

    Content type: Original investigation

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  13. Over the last 30 years the citizens of the United Arab Emirates have experienced major changes in life-style secondary to increased affluence. Currently, 1 in 5 adults have diabetes mellitus, but the associati...

    Authors: Latifa M Baynouna, Anthony D Revel, Nico JD Nagelkerke, Tariq M Jaber, Aziza O Omar, Nader M Ahmed, Mohammad K Nazirudeen, Mamdouh F Al Sayed, Fuad A Nour and Sameh Abdouni

    Citation: Cardiovascular Diabetology 2009 8:21

    Content type: Original investigation

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  14. Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the dev...

    Authors: Omar S Al-Attas, Nasser M Al-Daghri, Khalid Al-Rubeaan, Nancy F da Silva, Shaun L Sabico, Sudhesh Kumar, Philip G McTernan and Alison L Harte

    Citation: Cardiovascular Diabetology 2009 8:20

    Content type: Original investigation

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  15. Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus. There is an inverse relation between plasma testosterone and insulin sensitiv...

    Authors: Svetlana Kalinchenko, Alexandr Zemlyanoy and Louis J Gooren

    Citation: Cardiovascular Diabetology 2009 8:19

    Content type: Case Report

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  16. Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol (TAG) stores, and fibrosis in left ventri...

    Authors: Fabien Forcheron, Alexandra Basset, Pauline Abdallah, Peggy Del Carmine, Nicolas Gadot and Michel Beylot

    Citation: Cardiovascular Diabetology 2009 8:16

    Content type: Original investigation

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  17. Both insulin and thiazolidinediones (TZDs) are effective in the treatment of hyperglycaemia and amelioration of insulin resistance in type 2 diabetes but have side effects including weight gain and fluid reten...

    Authors: Mozhgan Dorkhan, Magnus Dencker, Martin Stagmo and Leif Groop

    Citation: Cardiovascular Diabetology 2009 8:15

    Content type: Original investigation

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  18. Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies ...

    Authors: Joey C Eisenmann, Mark A Sarzynski, Kim Glenn, Max Rothschild and Kate A Heelan

    Citation: Cardiovascular Diabetology 2009 8:14

    Content type: Original investigation

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  19. Obesity is a major risk factor for development and progression of hypertension and diabetes, which often coexist in obese patients. Losing weight by means of energy restriction and physical activity has been e...

    Authors: Guixiang Zhao, Earl S Ford, Chaoyang Li and Ali H Mokdad

    Citation: Cardiovascular Diabetology 2009 8:13

    Content type: Original investigation

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  20. Poor control of type 2 diabetes results in substantial long-term consequences. Studies of new diabetes treatments are rarely designed to assess mortality, complication rates and costs. We sought to estimate th...

    Authors: Sean D Sullivan, Rafael Alfonso-Cristancho, Chris Conner, Mette Hammer and Lawrence Blonde

    Citation: Cardiovascular Diabetology 2009 8:12

    Content type: Original investigation

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  21. The renin-angiotensin aldosterone system (RAAS) plays an important role in regulating the blood pressure and the genetic polymorphisms of RAAS genes has been extensively studied in relation to the cardiovascul...

    Authors: Vasudevan Ramachandran, Patimah Ismail, Johnson Stanslas and Norashikin Shamsudin

    Citation: Cardiovascular Diabetology 2009 8:11

    Content type: Original investigation

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  22. Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) s...

    Authors: Klaus Burkhardt, Sonja Schwarz, Chengrui Pan, Felix Stelter, Konstantin Kotliar, Maxilian Von Eynatten, Daniel Sollinger, Ines Lanzl, Uwe Heemann and Marcus Baumann

    Citation: Cardiovascular Diabetology 2009 8:10

    Content type: Original investigation

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  23. Insulin glargine (glargine) and premixed insulins (premix) are alternative insulin treatments. This analysis evaluated glycaemic control in 528 patients with type 1 (n = 183) or type 2 (n = 345) diabetes, afte...

    Authors: Peter Sharplin, Jason Gordon, John R Peters, Anthony P Tetlow, Andrea J Longman and Philip McEwan

    Citation: Cardiovascular Diabetology 2009 8:9

    Content type: Original investigation

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  24. High glucose could induce structure and function change in cardiomyocytes, PKC plays a core effect in the onset and progression of diabetic cardiomyopathy, but its underlying downstream signal transduction pat...

    Authors: Wang Min, Zhang Wen Bin, Zhou Bin Quan, Zhu Jun Hui and Fu Guo Sheng

    Citation: Cardiovascular Diabetology 2009 8:8

    Content type: Original investigation

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  25. The prevalence of vitamin D insufficiency and secondary hyperparathyroidism is high among morbidly obese subjects. Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated...

    Authors: Jøran Hjelmesæth, Dag Hofsø, Erlend T Aasheim, Trond Jenssen, Johan Moan, Helle Hager, Jo Røislien and Jens Bollerslev

    Citation: Cardiovascular Diabetology 2009 8:7

    Content type: Original investigation

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  26. A high prevalence of impaired glucose tolerance and unknown type 2-diabetes in patients with coronary heart disease and no previous diagnosis of diabetes have been reported. The aims of the present study were ...

    Authors: Eva C Knudsen, Ingebjørg Seljeflot, Michael Abdelnoor, Jan Eritsland, Arild Mangschau, Harald Arnesen and Geir Ø Andersen

    Citation: Cardiovascular Diabetology 2009 8:6

    Content type: Original investigation

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  27. The effects of pan-peroxisome proliferator-activated receptor (PPAR) ligand bezafibrate on N-terminal pro-B type natriuretic peptide (ProBNP) level in patients with coronary artery disease (CAD) is unknown. Th...

    Authors: Koichi Node, Teruo Inoue, Valentin Boyko, Ilan Goldberg, Enrique Z Fisman, Yehuda Adler, Ehud Schwammenthal, Zipora Matas, Solomon Behar and Alexander Tenenbaum

    Citation: Cardiovascular Diabetology 2009 8:5

    Content type: Original investigation

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  28. Poor control of blood glucose in diabetes is known to promote vascular dysfunction and hypertension. Diabetes was recently shown to be linked to an increased prevalence of pulmonary hypertension. The aim of th...

    Authors: Alison M Gurney and Frank C Howarth

    Citation: Cardiovascular Diabetology 2009 8:4

    Content type: Original investigation

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  29. Insulin glargine (glargine) and insulin NPH (NPH) are two basal insulin treatments. This study investigated the effect on glycaemic control of switching from a NPH-based regimen to a glargine-based regimen in ...

    Authors: Peter Sharplin, Jason Gordon, John R Peters, Anthony P Tetlow, Andrea J Longman and Philip McEwan

    Citation: Cardiovascular Diabetology 2009 8:3

    Content type: Original investigation

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  30. Differences in prevalence of cardiometabolic risk factors between different ethnic groups are largely unknown. We determined the variation in cardiometabolic risk profile according to ethnicity in a cohort ove...

    Authors: Mariska van Vliet, Inès A von Rosenstiel, Roger K Schindhelm, Desiderius PM Brandjes, Jos H Beijnen and Michaela Diamant

    Citation: Cardiovascular Diabetology 2009 8:2

    Content type: Original investigation

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  31. Mixed hyperlipidemia is common in patients with diabetes. Statins, the choice drugs, are effective at reducing lipoproteins that contain apolipoprotein B100, but they fail to exert good control over intestinal...

    Authors: Pedro Valdivielso, José Rioja, Carlota García-Arias, Miguel Angel Sánchez-Chaparro and Pedro González-Santos

    Citation: Cardiovascular Diabetology 2009 8:1

    Content type: Study protocol

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  32. The use of abciximab (c7E3 Fab) or eptifibatide improves clinical outcomes in diabetics undergoing percutaneous coronary intervention. These β3 integrin inhibitors antagonize fibrinogen binding to αIIbβ3 integrin...

    Authors: Alokkumar Pathak, Renyi Zhao, Jianhua Huang and George A Stouffer

    Citation: Cardiovascular Diabetology 2008 7:36

    Content type: Original investigation

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  33. Several aspects concerning the relationship between the metabolic syndrome and incident diabetes are incompletely understood including the magnitude of the risk estimate, potential gender differences in the as...

    Authors: Earl S Ford, Matthias B Schulze, Tobias Pischon, Manuela M Bergmann, Hans-Georg Joost and Heiner Boeing

    Citation: Cardiovascular Diabetology 2008 7:35

    Content type: Original investigation

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  34. Different mechanisms of diabetic-induced NO dysfunction have been proposed and central to most of them are significant changes in eNOS function as the rate-limiting step in NO bioavailability. eNOS exists in b...

    Authors: James Grijalva, Steven Hicks, Xiangmin Zhao, Sushma Medikayala, Pawel M Kaminski, Michael S Wolin and John G Edwards

    Citation: Cardiovascular Diabetology 2008 7:34

    Content type: Original investigation

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  35. We investigated the role of polyol pathway enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH) in mediating injury due to ischemia-reperfusion (IR) in Type 2 diabetic BBZ rat hearts. Specifically, w...

    Authors: Qing Li, Yuying C Hwang, Radha Ananthakrishnan, Peter J Oates, Dennis Guberski and Ravichandran Ramasamy

    Citation: Cardiovascular Diabetology 2008 7:33

    Content type: Original investigation

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  36. In Sweden, diabetes prevalence is increasing in spite of unchanged incidence, indicating improved survival. In recent US studies mortality in diabetic subjects has decreased over three decades, but only in men...

    Authors: Mats Eliasson, Mats Talbäck and Måns Rosén

    Citation: Cardiovascular Diabetology 2008 7:32

    Content type: Original investigation

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  37. Current guidelines from the European Society of Cardiology (ESC) define low thresholds for the diagnosis of dyslipidemia using total cholesterol (TC) and LDL-cholesterol (LDL-C) to guide treatment. Although be...

    Authors: Elisabeth Steinhagen-Thiessen, Peter Bramlage, Christian Lösch, Hans Hauner, Heribert Schunkert, Anja Vogt, Jürgen Wasem, Karl-Heinz Jöckel and Susanne Moebus

    Citation: Cardiovascular Diabetology 2008 7:31

    Content type: Original investigation

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  38. Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in...

    Authors: Robbert Meerwaldt, Thera Links, Clark Zeebregts, Rene Tio, Jan-Luuk Hillebrands and Andries Smit

    Citation: Cardiovascular Diabetology 2008 7:29

    Content type: Review

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  39. We examined, in a country of the African region, i) the prevalence of the metabolic syndrome (MetS) according to three definitions (ATP, WHO and IDF); ii) the distribution of the MetS criteria; iii) the level ...

    Authors: Clara Kelliny, Julita William, Walter Riesen, Fred Paccaud and Pascal Bovet

    Citation: Cardiovascular Diabetology 2008 7:27

    Content type: Original investigation

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  40. The role of structural and functional abnormalities of small vessels in diabetes cardiomyopathy remains unclear. Myocardial contrast echocardiography allows the quantification of myocardial blood flow at rest ...

    Authors: Bernard Cosyns, Steven Droogmans, Sophie Hernot, Céline Degaillier, Christian Garbar, Caroline Weytjens, Bram Roosens, Danny Schoors, Tony Lahoutte, Philippe R Franken and Guy Van Camp

    Citation: Cardiovascular Diabetology 2008 7:26

    Content type: Original investigation

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  41. Anaemia has been shown in previous studies to be a risk factor for cardiovascular disease in diabetic patients with chronic kidney disorder. This study was aimed to assess the prevalence of anaemia and kidney ...

    Authors: Chidum E Ezenwaka, Altheia Jones-LeCointe, Emeka Nwagbara, Dawn Seales and Fidelis Okali

    Citation: Cardiovascular Diabetology 2008 7:25

    Content type: Original investigation

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  42. Exenatide belongs to a new therapeutic class in the treatment of diabetes (incretin mimetics), allowing glucose-dependent glycaemic control in Type 2 diabetes. Randomised controlled trial data suggest that exe...

    Authors: Anette Woehl, Mark Evans, Anthony P Tetlow and Philip McEwan

    Citation: Cardiovascular Diabetology 2008 7:24

    Content type: Original investigation

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  43. Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.

    Authors: María E Sáez, Antonio Grilo, Francisco J Morón, Luis Manzano, María T Martínez-Larrad, Antonio González-Pérez, Javier Serrano-Hernando, Agustín Ruiz, Reposo Ramírez-Lorca and Manuel Serrano-Ríos

    Citation: Cardiovascular Diabetology 2008 7:23

    Content type: Original investigation

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