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  1. Baboons (Papio hamadryas Sp.) develop features of the cardiometabolic syndrome and represent a clinically-relevant animal model in which to study the aetiology of the disorder. To further evaluate the baboon as a...

    Authors: Paul B Higgins, Raul A Bastarrachea, Juan Carlos Lopez-Alvarenga, Maggie Garcia-Forey, J Michael Proffitt, V Saroja Voruganti, M Elizabeth Tejero, Vicki Mattern, Karin Haack, Robert E Shade, Shelley A Cole and Anthony G Comuzzie

    Citation: Cardiovascular Diabetology 2010 9:71

    Content type: Original investigation

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  2. The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, and nephropathy and coronary artery disease (CAD) in patients with...

    Authors: Xiaoxiang Yan, Motoaki Sano, Lin Lu, Wei Wang, Qi Zhang, Ruiyan Zhang, Lingjie Wang, Qiujing Chen, Keiichi Fukuda and Weifeng Shen

    Citation: Cardiovascular Diabetology 2010 9:70

    Content type: Original investigation

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  3. Epidemiological evidence suggests that fibrinogen and CRP are associated with coronary heart disease risk. High CRP in Indigenous Australians has been reported in previous studies including our 'Diabetes and R...

    Authors: Louise J Maple-Brown, Joan Cunningham, Nirjhar Nandi, Allison Hodge and Kerin O'Dea

    Citation: Cardiovascular Diabetology 2010 9:69

    Content type: Original investigation

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  4. This study evaluated the relationship between the G(-866)A polymorphism of the uncoupling protein 2 (UCP2) gene and high-sensitivity C reactive protein (hs-CRP) plasma levels in diabetic patients.

    Authors: Emanuela Lapice, Michele Pinelli, Elisabetta Pisu, Antonella Monticelli, Roberto Gambino, Gianfranco Pagano, Silvia Valsecchi, Sergio Cocozza, Gabriele Riccardi and Olga Vaccaro

    Citation: Cardiovascular Diabetology 2010 9:68

    Content type: Original investigation

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  5. Although exercise training has well-known cardiorespiratory and metabolic benefits, low compliance with exercise training programs is a fact, and the harmful effects of physical detraining regarding these adap...

    Authors: Alexandre M Lehnen, Natalia M Leguisamo, Graziela H Pinto, Melissa M Markoski, Kátia De Angelis, Ubiratan F Machado and Beatriz Schaan

    Citation: Cardiovascular Diabetology 2010 9:67

    Content type: Original investigation

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  6. Advanced glycation products (AGEs), as endogenous inflammatory mediator, compromise the physiological function of mesenchymal stem cells (MSCs). MSCs have a potential role in cell replacement therapy in acute ...

    Authors: Ke Yang, Xiao Qun Wang, Yu Song He, Lin Lu, Qiu Jing Chen, Jing Liu and Wei Feng Shen

    Citation: Cardiovascular Diabetology 2010 9:66

    Content type: Original investigation

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  7. To test the early effect of fructose-induced changes in fatty acid composition and oxidative stress markers in perivascular adipose tissue (PVAT) upon vascular contractility.

    Authors: Alejandro Rebolledo, Oscar R Rebolledo, Carlos A Marra, María E García, Ana R Roldán Palomo, Laura Rimorini and Juan J Gagliardino

    Citation: Cardiovascular Diabetology 2010 9:65

    Content type: Original investigation

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  8. Inflammation of adipose tissue (AT) has been recently accepted as a first step towards obesity-mediated insulin resistance. We could previously show that mice fed with high fat diet (HFD) develop systemic insu...

    Authors: Anna Foryst-Ludwig, Martin Hartge, Markus Clemenz, Christiane Sprang, Katharina Heß, Nikolaus Marx, Thomas Unger and Ulrich Kintscher

    Citation: Cardiovascular Diabetology 2010 9:64

    Content type: Original investigation

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  9. Left ventricular diastolic dysfunction (LVDD) is considered a precursor of diabetic cardiomyopathy, while insulin resistance (IR) is a precursor of type 2 diabetes mellitus (T2DM) and independently predicts he...

    Authors: Wilfried Dinh, Mark Lankisch, Werner Nickl, Daniel Scheyer, Thomas Scheffold, Frank Kramer, Thomas Krahn, Rolf M Klein, Michael Coll Barroso and Reiner Füth

    Citation: Cardiovascular Diabetology 2010 9:63

    Content type: Original investigation

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  10. Interleukin-6 (IL-6) is a multifunctional cytokine regulating humoral and cellular responses and playing a central role in inflammation and tissue injury. Its effects are mediated through interaction with its ...

    Authors: Enrique Z Fisman and Alexander Tenenbaum

    Citation: Cardiovascular Diabetology 2010 9:62

    Content type: Editorial

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  11. Normotensive non-diabetic relatives of type 1 diabetes (T1D) patients have an abnormal blood pressure response to exercise testing that is associated with indices of metabolic syndrome and increased oxidative ...

    Authors: Elena Matteucci, Cristina Consani, Maria Chiara Masoni and Ottavio Giampietro

    Citation: Cardiovascular Diabetology 2010 9:61

    Content type: Original investigation

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  12. Hypertension is an important independent risk factor for renal disease. If hypertension and chronic renal disease co-exist, as is common in patients with diabetes mellitus, the risk of cardiovascular disease i...

    Authors: Eberhard Ritz, Roland E Schmieder and Carol A Pollock

    Citation: Cardiovascular Diabetology 2010 9:60

    Content type: Review

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  13. This study aimed to construct a prediction model to identify subjects with high glycated hemoglobin (HbA1c) levels by incorporating anthropometric, lifestyle, clinical, and biochemical information in a large c...

    Authors: Kuo-Liong Chien, Hung-Ju Lin, Bai-Chin Lee, Hsiu-Ching Hsu and Ming-Fong Chen

    Citation: Cardiovascular Diabetology 2010 9:59

    Content type: Original investigation

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  14. Cardiovascular disease (CVD) risk, although perceived to be high, is often difficult to demonstrate in disease free (healthy) obese adults.

    Authors: Alok K Gupta, Germaine Cornelissen, Frank L Greenway, Vijay Dhoopati, Franz Halberg and William D Johnson

    Citation: Cardiovascular Diabetology 2010 9:58

    Content type: Original investigation

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  15. Thiazolidinediones, used for the treatment of patients with type 2 diabetes mellitus (DM2), are associated with an increased incidence of heart failure. We sought to investigate the effects of pioglitazone on ...

    Authors: Katerina K Naka, Konstantinos Pappas, Katerina Papathanassiou, Nikolaos D Papamichael, Nikolaos Kazakos, Chryssanthi Kanioglou, Demetrios Makriyiannis, Christos S Katsouras, Kostas Liveris, Agathocles Tsatsoulis and Lampros K Michalis

    Citation: Cardiovascular Diabetology 2010 9:57

    Content type: Original investigation

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  16. Early markers of diabetic autonomic neuropathy (DAN) in an electrocardiogram (ECG) include elevated R wave amplitudes, widening of QTc intervals and decreased heart rate variability (HRV). The severity of DAN has...

    Authors: Lisa VanHoose, Youssef Sawers, Rajprasad Loganathan, James L Vacek, Lisa Stehno-Bittel, Lesya Novikova, Muhammed Al-Jarrah and Irina V Smirnova

    Citation: Cardiovascular Diabetology 2010 9:56

    Content type: Original investigation

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  17. Diabetic patients experience exaggerated intimal hyperplasia after endovascular procedures. Recently it has been shown that circulating smooth muscle progenitor cells (SPC) contribute to intimal hyperplasia. W...

    Authors: Peter E Westerweel, Cindy TJ van Velthoven, Tri Q Nguyen, Krista den Ouden, Dominique PV de Kleijn, Marie Jose Goumans, Roel Goldschmeding and Marianne C Verhaar

    Citation: Cardiovascular Diabetology 2010 9:55

    Content type: Original investigation

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  18. The optimum oral pharmacological treatment of diabetes mellitus to reduce cardiovascular disease and mortality following myocardial infarction has not been established. We therefore set out to investigate the ...

    Authors: Casper H Jørgensen, Gunnar H Gislason, Charlotte Andersson, Ole Ahlehoff, Mette Charlot, Tina K Schramm, Allan Vaag, Steen Z Abildstrøm, Christian Torp-Pedersen and Peter R Hansen

    Citation: Cardiovascular Diabetology 2010 9:54

    Content type: Original investigation

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  19. Patients with type 2 diabetes are at an increased risk for disease and treatment related complications after the initial approach of oral mono/dual antidiabetic therapy has failed. Data from clinical practice ...

    Authors: Peter Bramlage, Christiane Binz, Anselm K Gitt, Michael Krekler, Tanja Plate, Evelin Deeg and Diethelm Tschöpe

    Citation: Cardiovascular Diabetology 2010 9:53

    Content type: Study protocol

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  20. The cardiac troponins are biomarkers used for diagnosis of myocardial injury. They are also powerful prognostic markers in many diseases and settings. Recently introduced high-sensitivity assays indicate that ...

    Authors: Jonas Hallén, Odd Erik Johansen, Kåre I Birkeland, Lars Gullestad, Svend Aakhus, Knut Endresen, Solve Tjora, Allan S Jaffe and Dan Atar

    Citation: Cardiovascular Diabetology 2010 9:52

    Content type: Original investigation

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  21. It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention. On this basis the aim of our ...

    Authors: Antonino Tuttolomondo, Sergio La Placa, Domenico Di Raimondo, Chiara Bellia, Antonietta Caruso, Bruna Lo Sasso, Giovanni Guercio, Giuseppe Diana, Marcello Ciaccio, Giuseppe Licata and Antonio Pinto

    Citation: Cardiovascular Diabetology 2010 9:50

    Content type: Original investigation

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  22. Hyperhomocysteinemia (HHcy) and hyperglycemia cause diabetic cardiomyopathy by inducing oxidative stress and attenuating peroxisome proliferator- activated receptor (PPAR) gamma. However, their synergistic con...

    Authors: Paras K Mishra, Neetu Tyagi, Utpal Sen, Irving G Joshua and Suresh C Tyagi

    Citation: Cardiovascular Diabetology 2010 9:49

    Content type: Original investigation

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  23. Ambigous results exist on fetuin-A as marker for vascular disease in type 2 diabetes. This study aims to define the role of fetuin-A as marker for micro- and macrovascular disease in a high risk population of ...

    Authors: Marcel Roos, Dimitrios Oikonomou, Maximilian von Eynatten, Peter B Luppa, Uwe Heemann, Jens Lutz, Marcus Baumann, Peter P Nawroth, Angelika Bierhaus and Per M Humpert

    Citation: Cardiovascular Diabetology 2010 9:48

    Content type: Original investigation

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  24. Inflammation plays an important role in the pathophysiology of both atherosclerosis and type 2 diabetes and some inflammatory markers may also predict the risk of developing type 2 diabetes. The aims of the pr...

    Authors: Eva C Knudsen, Ingebjørg Seljeflot, Abdelnoor Michael, Jan Eritsland, Arild Mangschau, Carl Müller, Harald Arnesen and Geir Ø Andersen

    Citation: Cardiovascular Diabetology 2010 9:47

    Content type: Original investigation

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  25. Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. Data obtained from muscle biopsies have demonstrated altered insulin signaling (IS) in patients with MetS. The IS regul...

    Authors: Evasio Pasini, Vincenzo Flati, Silvia Paiardi, Damiano Rizzoni, Enzo Porteri, Roberto Aquilani, Deodato Assanelli, Giovanni Corsetti, Silvia Speca, Rita Rezzani, Carolina De Ciuceis and Enrico Agabiti-Rosei

    Citation: Cardiovascular Diabetology 2010 9:46

    Content type: Original investigation

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  26. Although diabetic patients have an increased rate of cardio-vascular events, there is considerable heterogeneity with respect to cardiovascular risk, requiring new approaches to individual cardiovascular risk ...

    Authors: Hannes M Findeisen, Sabine Weckbach, Renée G Stark, Maximilian F Reiser, Stefan O Schoenberg and Klaus G Parhofer

    Citation: Cardiovascular Diabetology 2010 9:44

    Content type: Original investigation

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  27. The mechanisms responsible for the cardiovascular mortality in type I diabetes (DM) have not been defined completely. We have shown in conscious dogs with DM that: 1) baseline coronary blood flow (CBF) was signif...

    Authors: Caroline Ojaimi, Shintaro Kinugawa, Fabio A Recchia and Thomas H Hintze

    Citation: Cardiovascular Diabetology 2010 9:43

    Content type: Original investigation

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  28. The beta-1 adrenergic receptor (β1AR) plays a fundamental role in the regulation of cardiovascular functions. It carries a nonsynonymous single nucleotide polymorphism in its carboxyl terminal tail (Arg389Gly), w...

    Authors: Anna E Hakalahti, Jari M Tapanainen, Juhani M Junttila, Kari S Kaikkonen, Heikki V Huikuri and Ulla E Petäjä-Repo

    Citation: Cardiovascular Diabetology 2010 9:42

    Content type: Original investigation

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  29. Accumulation of oxidized low-density lipoproteins in the intimae of arteries and endothelial dysfunction are key events in the development of atherosclerosis. Patients with metabolic syndrome are at high risk ...

    Authors: Hanna Pohjantähti-Maaroos, Ari Palomäki, Päivi Kankkunen, Ruth Laitinen, Sari Husgafvel and Kalevi Oksanen

    Citation: Cardiovascular Diabetology 2010 9:41

    Content type: Original investigation

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  30. The use of carotid intima-media thickness (carotid IMT) as a surrogate marker of cardiovascular disease is increasing and the method has now also been applied in several trials investigating patients with type...

    Authors: Louise Lundby-Christensen, Thomas P Almdal, Bendix Carstensen, Lise Tarnow and Niels Wiinberg

    Citation: Cardiovascular Diabetology 2010 9:40

    Content type: Methodology

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  31. C-reactive protein (CRP), a biomarker of inflammation, has been associated with increased risk of developing cardiovascular disease. Common variants of the hepatocyte nuclear factor 1A (HNF1A) gene encoding HNF-1...

    Authors: Sylvia H Ley, Robert A Hegele, Philip W Connelly, Stewart B Harris, Mary Mamakeesick, Henian Cao, Joel Gittelsohn, Ravi Retnakaran, Bernard Zinman and Anthony J Hanley

    Citation: Cardiovascular Diabetology 2010 9:39

    Content type: Original investigation

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  32. Studies focusing on the add-on effects of angiotensin II type 1 receptor blockers (ARBs) other than their antihypertensive effect are receiving attention. However, the effects of prolonged administration of AR...

    Authors: Yayoi Nishida, Yasuo Takahashi, Tomohiro Nakayama, Masayoshi Soma, Noboru Kitamura and Satoshi Asai

    Citation: Cardiovascular Diabetology 2010 9:38

    Content type: Original investigation

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  33. Hypertensive patients with reduced blood pressure fall (BPF) at night are at higher risk of cardiovascular events (CVE).

    Authors: João S Felício, Ana Carolina CB de Souza, Nárcia Kohlmann, Oswaldo Kohlmann Jr, Arthur B Ribeiro and Maria T Zanella

    Citation: Cardiovascular Diabetology 2010 9:36

    Content type: Original investigation

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  34. Four single nucleotide polymorphisms (SNPs) (rs2237892, rs2237895, rs2237897, and rs2283228) in KCNQ1 are reported to be associated with type 2 diabetes mellitus (T2DM), possibly caused by a reduction in insulin ...

    Authors: Zhong Chen, Quanzhong Yin, Genshan Ma and Qi Qian

    Citation: Cardiovascular Diabetology 2010 9:35

    Content type: Original investigation

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  35. Based on the AHA/NHLBI-definition three out of five cardiometabolic traits must be present for the diagnosis of the metabolic syndrome (MetS), resulting in 16 different combination types. The associated cardio...

    Authors: Susanne Moebus, Chakrapani Balijepalli, Christian Lösch, Laura Göres, Bernd von Stritzky, Peter Bramlage, Jürgen Wasem and Karl-Heinz Jöckel

    Citation: Cardiovascular Diabetology 2010 9:34

    Content type: Original investigation

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  36. We sought to explore the association of variant rs1333049 on chromosome 9p21.3 with coronary artery disease (CAD) and angiographic plaque progression in non-diabetic and type 2 diabetic patients.

    Authors: Wei Wang, Wenhui Peng, Xianling Zhang, Lin Lu, Ruiyan Zhang, Qi Zhang, Lingjie Wang, Qiujing Chen and Weifeng Shen

    Citation: Cardiovascular Diabetology 2010 9:33

    Content type: Original investigation

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  37. Activation of glucagon-like peptide-1 (GLP-1) receptors improves insulin sensitivity and induces vasodilatation and diuresis. AC3174 is a peptide analogue with pharmacologic properties similar to the GLP-1 rec...

    Authors: Que Liu, Lisa Adams, Anatoly Broyde, Rayne Fernandez, Alain D Baron and David G Parkes

    Citation: Cardiovascular Diabetology 2010 9:32

    Content type: Original investigation

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  38. Substantial evidence suggests that high glucose (HG) causes endothelial cell damage; however, the potential mechanism therein has yet to be clarified. The aim of this study was to investigate the influence of ...

    Authors: Rining Tang, Qing Li, Linli Lv, Houyong Dai, Min Zheng, Kunling Ma and Bicheng Liu

    Citation: Cardiovascular Diabetology 2010 9:31

    Content type: Original investigation

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  39. Metabolic syndrome (MetS) is frequently characterized by elevated liver enzymes, including gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT). Our objective was to evaluate the range of preval...

    Authors: Arie Steinvil, Itzhak Shapira, Orit Kliuk Ben-Bassat, Michael Cohen, Yaffa Vered, Shlomo Berliner and Ori Rogowski

    Citation: Cardiovascular Diabetology 2010 9:30

    Content type: Original investigation

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  40. In a previous study, we demonstrated that the thickness of epicardial adipose tissue (EAT), measured by echocardiography, was increased in patients with metabolic syndrome (MS) and coronary artery disease (CAD...

    Authors: Jin-Sun Park, Sung-Gyun Ahn, Jung-Won Hwang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk and Joon-Han Shin

    Citation: Cardiovascular Diabetology 2010 9:29

    Content type: Original investigation

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  41. The purpose of this study was to test the hypothesis that sidestream tobacco smoke extracts would inhibit the culture of endothelial cells and enhance platelet aggregation under diabetic vascular conditions. S...

    Authors: David A Rubenstein, Blake E Morton and Wei Yin

    Citation: Cardiovascular Diabetology 2010 9:28

    Content type: Original investigation

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  42. Insulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. High molecular weight adiponectin (HMWA) is considered the active form of adiponectin and a better mar...

    Authors: Paloma Almeda-Valdes, Daniel Cuevas-Ramos, Roopa Mehta, Francisco J Gomez-Perez, Ivette Cruz-Bautista, Olimpia Arellano-Campos, Mariana Navarrete-Lopez and Carlos A Aguilar-Salinas

    Citation: Cardiovascular Diabetology 2010 9:26

    Content type: Original investigation

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  43. In patients with myocardial infarction or heart failure, right ventricular (RV) dysfunction is associated with death, shock and arrhythmias. In patients with type 2 diabetes mellitus, structural and functional...

    Authors: Charissa E van den Brom, Joanna WAM Bosmans, Ronald Vlasblom, Louis M Handoko, Marc C Huisman, Mark Lubberink, Carla FM Molthoff, Adriaan A Lammertsma, Margriet D Ouwens, Michaela Diamant and Christa Boer

    Citation: Cardiovascular Diabetology 2010 9:25

    Content type: Original investigation

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  44. Diabetes is a major challenge for the health care system and especially for the primary care provider. The Chronic Care Model represents an evidence-based framework for the care for chronically ill. An increas...

    Authors: Anja Frei, Corinne Chmiel, Hansueli Schläpfer, Beatrice Birnbaum, Ulrike Held, Johann Steurer and Thomas Rosemann

    Citation: Cardiovascular Diabetology 2010 9:23

    Content type: Study protocol

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