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  1. The role of Lipoprotein (a) cholesterol {Lp(a)-C}as an additional and/or independent risk factor for cardiovascular disease (CVD) is not clear. We evaluated the associations between Lp(a)-C and other CVD risk ...

    Authors: Sushma Sharma, Jayshree Merchant and Sharon E Fleming

    Citation: Cardiovascular Diabetology 2012 11:10

    Content type: Original investigation

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  2. An impairment of cardiovascular function in streptozotocin (STZ)-diabetic rats has been mentioned within 5 days-to-3 months of induction. ATP-sensitive potassium (KATP) channels are expressed on cardiac sarcolemm...

    Authors: Zhih-Cherng Chen, Yung-Ze Cheng, Li-Jen Chen, Kai-Chun Cheng, Yin- Xiao Li and Juei- Tang Cheng

    Citation: Cardiovascular Diabetology 2012 11:8

    Content type: Original investigation

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  3. The role of advanced glycation end products (AGEs) in the development of diabetes, especially diabetic complications, has been emphasized in many reports. Accumulation of AGEs in the vasculature triggers a ser...

    Authors: Jiping Wang, Hongxia Liu, Bo Chen, Qiang Li, Xuliang Huang, Liqun Wang, Xiaohua Guo and Qiaobing Huang

    Citation: Cardiovascular Diabetology 2012 11:7

    Content type: Original investigation

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  4. Adiposity greatly increases the risk of atherothrombotic events, a pathological condition where a chronic state of oxidative stress is reported to play a major role. This study aimed to investigate the involve...

    Authors: Priscila F Monteiro, Rafael P Morganti, Maria A Delbin, Marina C Calixto, Maria E Lopes-Pires, Sisi Marcondes, Angelina Zanesco and Edson Antunes

    Citation: Cardiovascular Diabetology 2012 11:5

    Content type: Original investigation

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  5. The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial pe...

    Authors: Shuhei Matsumoto, Sungsam Cho, Shinya Tosaka, Ushio Higashijima, Takuji Maekawa, Tetsuya Hara and Koji Sumikawa

    Citation: Cardiovascular Diabetology 2012 11:4

    Content type: Original investigation

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  6. This study investigated the cardiovascular (CV) safety profile of the dipeptidyl peptidase (DPP)-4 inhibitor linagliptin versus comparator treatments.

    Authors: Odd Erik Johansen, Dietmar Neubacher, Maximilian von Eynatten, Sanjay Patel and Hans-Juergen Woerle

    Citation: Cardiovascular Diabetology 2012 11:3

    Content type: Original investigation

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  7. Carotid intima-media thickness (IMT) is an useful surrogate marker of cardiovascular disease. Associations between uric acid (UA), metabolic syndrome (MetS) and carotid IMT have been reported, but findings reg...

    Authors: Shuzo Takayama, Ryuichi Kawamoto, Tomo Kusunoki, Masanori Abe and Morikazu Onji

    Citation: Cardiovascular Diabetology 2012 11:2

    Content type: Original investigation

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  8. Previous randomized controlled trials demonstrated a protective effect of renin angiotensin system blocking agents for the development of type-2 diabetes in patients with pre-diabetes. However, there are no re...

    Authors: Walter Zidek, Joachim Schrader, Stephan Lüders, Stephan Matthaei, Christoph Hasslacher, Joachim Hoyer, Claudia Zemmrich, Peter Bramlage, Claus-Dieter Sturm and W Dieter Paar

    Citation: Cardiovascular Diabetology 2012 11:1

    Content type: Original investigation

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  9. The increased risk of cardiovascular disease (CVD) in diabetic compared to non-diabetic subjects seems to decrease with age. Whether this age-related reduction applies to CVD risk factors, and whether it is li...

    Authors: Margret Leosdottir, Ronnie Willenheimer, Margaretha Persson and Peter M Nilsson

    Citation: Cardiovascular Diabetology 2011 10:118

    Content type: Original investigation

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  10. Type 2 diabetes mellitus (T2DM) is associated with an increased risk of atherosclerotic vascular disease, but it is unknown whether the other way around is true too. C57BL/6 (B6) and BALB/cJ (BALB) are two mou...

    Authors: Jing Li, Qian Wang, Weidong Chai, Mei-Hua Chen, Zhenqi Liu and Weibin Shi

    Citation: Cardiovascular Diabetology 2011 10:117

    Content type: Original investigation

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  11. This study investigates the associations between changes in serum Triglycerides (S-TG), -Urate (S-Urate), and -Glucose (S-Glu) and changes in serum Calcium (S-Ca), -Magnesium (S-Mg), and -Phosphate (S-P) in pa...

    Authors: Lena Håglin, Lennart Bäckman and Birgitta Törnkvist

    Citation: Cardiovascular Diabetology 2011 10:116

    Content type: Original investigation

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  12. Glucose fluctuations including robust postprandial hyperglycemia are a risk for promoting atherosclerosis and diabetic complications. The α-glucosidase inhibitors and the dipeptidyl peptidase-4 (DPP-4) inhibit...

    Authors: Miyako Kishimoto and Mitsuhiko Noda

    Citation: Cardiovascular Diabetology 2011 10:115

    Content type: Original investigation

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  13. Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes. Inte...

    Authors: Xizhen Xu, Ling Tu, Luyun Wang, Xiaosai Fang and Dao Wen Wang

    Citation: Cardiovascular Diabetology 2011 10:114

    Content type: Original investigation

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    The Erratum to this article has been published in Cardiovascular Diabetology 2014 13:17

  14. Patients with type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction and arterial stiffness. Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic st...

    Authors: Wen-Sheng Yue, Kui-Kai Lau, Chung-Wah Siu, Mei Wang, Guo-Hui Yan, Kai-Hang Yiu and Hung-Fat Tse

    Citation: Cardiovascular Diabetology 2011 10:113

    Content type: Original investigation

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  15. Metabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-γ2 (PPARγ2) Pro12Ala and ...

    Authors: Angela Passaro, Edoardo Dalla Nora, Caterina Marcello, Francesca Di Vece, Mario Luca Morieri, Juana M Sanz, Cristina Bosi, Renato Fellin and Giovanni Zuliani

    Citation: Cardiovascular Diabetology 2011 10:112

    Content type: Original investigation

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  16. In the general population, peripheral metabolic complications (MC) increase the risk for left ventricular dysfunction. Human immunodeficiency virus infection (HIV) and combination anti-retroviral therapy (cART...

    Authors: W Todd Cade, Dominic N Reeds, E Turner Overton, Pilar Herrero, Alan D Waggoner, Victor G Davila-Roman, Sherry Lassa-Claxton, Robert J Gropler, Pablo F Soto, Melissa J Krauss, Kevin E Yarasheski and Linda R Peterson

    Citation: Cardiovascular Diabetology 2011 10:111

    Content type: Original investigation

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  17. Increased IL-18 serum levels have been associated with diabetes type 2, metabolic syndrome and the severity of atherosclerosis. The present study investigated the presence and influence of IL-18 genetic varian...

    Authors: Trine B Opstad, Alf Å Pettersen, Harald Arnesen and Ingebjørg Seljeflot

    Citation: Cardiovascular Diabetology 2011 10:110

    Content type: Original investigation

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  18. To examine the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on visceral fat adiposity, appetite, food preference, and biomarkers of cardiovascular system in Japanese patients with type 2...

    Authors: Kana Inoue, Norikazu Maeda, Susumu Kashine, Yuya Fujishima, Junji Kozawa, Aki Hiuge-Shimizu, Kohei Okita, Akihisa Imagawa, Tohru Funahashi and Iichiro Shimomura

    Citation: Cardiovascular Diabetology 2011 10:109

    Content type: Original investigation

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  19. There is controversy about the specific pathophysiology of metabolic syndrome (MS) but several authors have argued that hyperinsulinemia is a key feature of the cluster. We aimed to assess whether the baseline...

    Authors: Ki-Chul C Sung, Mi-Hae H Seo, Eun-Jung J Rhee and Andrew M Wilson

    Citation: Cardiovascular Diabetology 2011 10:108

    Content type: Original investigation

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  20. Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and mobilization. However, it is unknown whether the mobilization of BM-CP...

    Authors: Ilkay Bozdag-Turan, R Goekmen Turan, C Hakan Turan, Sophie Ludovicy, Ibrahim Akin, Stephan Kische, Nicole S Arsoy, Henrik Schneider, Jasmin Ortak, Tim Rehders, Tina Hermann, Liliya Paranskaya, Peter Kohlschein, Manuela Bastian, A Tulga Ulus, Kurtulus Sahin…

    Citation: Cardiovascular Diabetology 2011 10:107

    Content type: Original investigation

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  21. The growing prevalence rate of pediatric obesity, which is frequently accompanied by several cardiometabolic risk factors, has become a serious global health issue. To date, little is known regarding differenc...

    Authors: Mariska van Vliet, Martijn W Heymans, Inès A von Rosenstiel, Desiderius PM Brandjes, Jos H Beijnen and Michaela Diamant

    Citation: Cardiovascular Diabetology 2011 10:106

    Content type: Review

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  22. Nicorandil, an anti-angina agent, reportedly improves outcomes even in angina patients with diabetes. However, the precise mechanism underlying the beneficial effect of nicorandil on diabetic patients has not ...

    Authors: Ken-ichi Serizawa, Kenji Yogo, Ken Aizawa, Yoshihito Tashiro and Nobuhiko Ishizuka

    Citation: Cardiovascular Diabetology 2011 10:105

    Content type: Original investigation

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  23. Prediabetes (PreDM) in asymptomatic adults is associated with abnormal circadian blood pressure variability (abnormal CBPV).

    Authors: Sivarajan Kumarasamy, Kathirvel Gopalakrishnan, Dong Hyun Kim, Nader G Abraham, William D Johnson, Bina Joe and Alok K Gupta

    Citation: Cardiovascular Diabetology 2011 10:104

    Content type: Original investigation

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  24. Adipokines contribute directly to the atherosclerotic process, connecting metabolic disorders such as obesity and diabetes to cardiovascular disease. Omentin-1 is a recently discovered novel adipokine, so data...

    Authors: Hye Jin Yoo, Soon Young Hwang, Ho Cheol Hong, Hae Yoon Choi, Sae Jeong Yang, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Dong Seop Choi and Sei Hyun Baik

    Citation: Cardiovascular Diabetology 2011 10:103

    Content type: Original investigation

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  25. Patients with the metabolic syndrome are more likely to develop type 2 diabetes and may have an increased risk of cardiovascular disease (CVD) events.We aimed to establish whether CVD event rates were influenc...

    Authors: Russell Scott, Mark Donoghoe, Gerald F Watts, Richard O'Brien, Christopher Pardy, Marja-Riitta Taskinen, Timothy ME Davis, Peter G Colman, Patrick Manning, Gregory Fulcher and Anthony C Keech

    Citation: Cardiovascular Diabetology 2011 10:102

    Content type: Original investigation

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  26. Soluble ST2, a member of the of the Toll/IL-1 superfamily, is a novel biomarker with exceptional predictive value in heart failure and myocardial infarction- related mortality as well as in acute dyspneic stat...

    Authors: Evangelos Fousteris, Andreas Melidonis, George Panoutsopoulos, Konstantinos Tzirogiannis, Stefanos Foussas, Anastasios Theodosis-Georgilas, Stavros Tzerefos, Spiridon Matsagos, Eleni Boutati, Theofanis Economopoulos, George Dimitriadis and Sotirios Raptis

    Citation: Cardiovascular Diabetology 2011 10:101

    Content type: Original investigation

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  27. Insulin resistance is accompanied by a cluster of metabolic changes, often referred to as metabolic syndrome. Metabolic syndrome is associated with an increased cardiovascular risk in patients with manifest ar...

    Authors: Sandra N Verhagen, Annemarie MJ Wassink, Yolanda van der Graaf, Petra M Gorter and Frank LJ Visseren

    Citation: Cardiovascular Diabetology 2011 10:100

    Content type: Original investigation

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  28. Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcif...

    Authors: Melissa Simpson, Janet K Snell-Bergeon, Gregory L Kinney, Orit Lache, Rachel Miller-Lotan, Yefim Anbinder, Marian J Rewers and Andrew P Levy

    Citation: Cardiovascular Diabetology 2011 10:99

    Content type: Original investigation

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  29. The prognostic value of hemoglobin A1c (HbA1c) in coronary artery disease (CAD) remains controversial. Herein, we conducted a systematic review to quantify the association between elevated HbA1c levels and all...

    Authors: Yao Liu, Yan-min Yang, Jun Zhu, Hui-qiong Tan, Yan Liang and Jian-dong Li

    Citation: Cardiovascular Diabetology 2011 10:98

    Content type: Original investigation

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  30. Numerous evidences suggest that diabetic heart is characterized by compromised ventricular contraction and prolonged relaxation attributable to multiple causative factors including calcium accumulation, oxidat...

    Authors: Vasundhara Kain, Sandeep Kumar and Sandhya L Sitasawad

    Citation: Cardiovascular Diabetology 2011 10:97

    Content type: Original investigation

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  31. Both genetic and environmental factors play a role in the pathogenesis of type 2 diabetes and cardiovascular diseases. The magnitude of genetic and environmental influences may vary in different populations an...

    Authors: György Jermendy, Tamás Horváth, Levente Littvay, Rita Steinbach, Ádám L Jermendy, Ádám D Tárnoki, Dávid L Tárnoki, Júlia Métneki and János Osztovits

    Citation: Cardiovascular Diabetology 2011 10:96

    Content type: Original investigation

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  32. Diabetes mellitus and renal dysfunction are prognostic factors after acute myocardial infarction (AMI). However, few studies have assessed the effects of renal insufficiency in association with diabetes in the...

    Authors: Chang Seong Kim, Joon Seok Choi, Jeong Woo Park, Eun Hui Bae, Seong Kwon Ma, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim and Soo Wan Kim

    Citation: Cardiovascular Diabetology 2011 10:95

    Content type: Original investigation

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  33. Aldosterone levels are elevated in a rat model of type 2 diabetes mellitus, the Zucker Diabetic fatty rat (ZDF). Moreover blood pressure in ZDF rats is salt-sensitive. The aim of this study was to examine the ...

    Authors: Markus Resch, Peter Schmid, Kerstin Amann, Sabine Fredersdorf, Joachim Weil, Christian Schach, Christoph Birner, Daniel P Griese, Peter Kreuzer, Sabine Brunner, Andreas Luchner, Günter AJ Riegger and Dierk H Endemann

    Citation: Cardiovascular Diabetology 2011 10:94

    Content type: Original investigation

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  34. The triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been advocated as a simple clinical indicator of insulin resistance. Thresholds of TG/HDL-C appeared to depend on ethnicity. Howeve...

    Authors: Jui-Kun Chiang, Ning-Sheng Lai, Jiunn-Kae Chang and Malcolm Koo

    Citation: Cardiovascular Diabetology 2011 10:93

    Content type: Original investigation

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  35. Diabetic cardiomyopathy (CMP) is a common and disabling disease in diabetic patients, however no effective treatments have been developed. Although granulocyte-colony stimulating factor (G-CSF) improves heart ...

    Authors: Young-Hyo Lim, Jun-Ho Joe, Ki-Seok Jang, Yi-Sun Song, Byung-Im So, Cheng-Hu Fang, Jinho Shin, Jung-Hyun Kim, Heon-Kil Lim and Kyung-Soo Kim

    Citation: Cardiovascular Diabetology 2011 10:92

    Content type: Original investigation

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  36. Carvedilol has been shown to be superior to metoprolol tartrate to improve clinical outcomes in patients with heart failure (HF), yet the mechanisms responsible for these differences remain unclear. We examine...

    Authors: Britt Falskov, Thomas Steffen Hermann, Jakob Raunsø, Buris Christiansen, Christian Rask-Madsen, Atheline Major-Pedersen, Lars Køber, Christian Torp-Pedersen and Helena Dominguez

    Citation: Cardiovascular Diabetology 2011 10:91

    Content type: Original investigation

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  37. Cardiovascular disease morbidity-mortality is greater in people with type 2 diabetes mellitus or metabolic syndrome. The purpose of this study was to evaluate the yearly evolution of organ damage markers in di...

    Authors: Manuel A Gomez-Marcos, Jose I Recio-Rodríguez, Maria C Patino-Alonso, Cristina Agudo-Conde, Leticia Gomez-Sanchez, Emiliano Rodriguez-Sanchez, Marta Gomez-Sanchez and Luis Garcia-Ortiz

    Citation: Cardiovascular Diabetology 2011 10:90

    Content type: Original investigation

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  38. B3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic ab...

    Authors: Aibek E Mirrakhimov, Alina S Kerimkulova, Olga S Lunegova, Cholpon B Moldokeeva, Yulia V Zalesskaya, Samai S Abilova, Nurmira A Sovhozova, Almaz A Aldashev and Erkin M Mirrakhimov

    Citation: Cardiovascular Diabetology 2011 10:89

    Content type: Original investigation

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  39. Carotid intima-media thickness (IMT), indices of large artery stiffness and measures of endothelium function may be used as markers of early atherosclerosis in type 1 diabetes mellitus (T1DM). The aim of the p...

    Authors: Carlo Palombo, Michaela Kozakova, Carmela Morizzo, Laura Gnesi, Maria Chiara Barsotti, Paolo Spontoni, Francesco Massart, Paolo Salvi, Alberto Balbarini, Giuseppe Saggese, Rossella Di Stefano and Giovanni Federico

    Citation: Cardiovascular Diabetology 2011 10:88

    Content type: Original investigation

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  40. Growing evidence suggests that epicardial adipose tissue (EAT) may play a key role in the pathogenesis and development of coronary artery disease (CAD) by producing several inflammatory adipokines. Chemerin, a...

    Authors: Xiuying Gao, Shuhua Mi, Fuzhuang Zhang, Fengying Gong, Yongqiang Lai, Feng Gao, Xiaoxia Zhang, Linjie Wang and Hong Tao

    Citation: Cardiovascular Diabetology 2011 10:87

    Content type: Original investigation

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  41. We analyzed the effects of insulin therapy, age and gender on the risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) according to glycemic control.

    Authors: Toshio Hayashi, Seinosuke Kawashima, Hideki Nomura, Hideki Itoh, Hiroshi Watanabe, Takashi Ohrui, Koutaro Yokote, Hirohito Sone, Yoshiyuki Hattori, Masao Yoshizumi, Koichiro Ina and Kiyoshi Kubota

    Citation: Cardiovascular Diabetology 2011 10:86

    Content type: Original investigation

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  42. Progressive remodeling after myocardial infarction (MI) is a leading cause of morbidity and mortality. Recently, glucagon-like peptide (GLP)-1 was shown to have cardioprotective effects, but treatment with GLP...

    Authors: Meimei Yin, Herman HW Silljé, Maxi Meissner, Wiek H van Gilst and Rudolf A de Boer

    Citation: Cardiovascular Diabetology 2011 10:85

    Content type: Original investigation

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  43. Obstructive sleep apnea (OSA) is a common yet underdiagnosed condition. The aim of our study is to test whether prediabetes and type 2 diabetes are associated with obstructive sleep apnea (OSA) in extremely ob...

    Authors: Jan Magnus Fredheim, Jan Rollheim, Torbjørn Omland, Dag Hofsø, Jo Røislien, Kristian Vegsgaard and Jøran Hjelmesæth

    Citation: Cardiovascular Diabetology 2011 10:84

    Content type: Original investigation

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  44. Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized that mediate effects of adiponectin in various tis...

    Authors: Niina Siitonen, Leena Pulkkinen, Jaana Lindström, Marjukka Kolehmainen, Ursula Schwab, Johan G Eriksson, Pirjo Ilanne-Parikka, Sirkka Keinänen-Kiukaanniemi, Jaakko Tuomilehto and Matti Uusitupa

    Citation: Cardiovascular Diabetology 2011 10:83

    Content type: Original investigation

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  45. To investigate the effect of physician- and patient-specific feedback with benchmarking on the quality of care in adults with type 2 diabetes mellitus (T2DM).

    Authors: Frank Nobels, Noëmi Debacker, Carlos Brotons, Moses Elisaf, Michel P Hermans, Georges Michel and Erik Muls

    Citation: Cardiovascular Diabetology 2011 10:82

    Content type: Methodology

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  46. Metabolic syndrome (MS) is a clustering of cardiometabolic risk factors that is considered a predictor of cardiovascular disease, type 2 diabetes and mortality. There is no consistent evidence on whether the M...

    Authors: Vicente Martínez-Vizcaino, Francisco B Ortega, Montserrat Solera-Martínez, Jonatan R Ruiz, Idoia Labayen, Diva Eensoo, Jaanus Harro, Helle-Mai Loit, Toomas Veidebaum and Michael Sjöström

    Citation: Cardiovascular Diabetology 2011 10:81

    Content type: Original investigation

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  47. Type 2 diabetes and the metabolic syndrome are associated with impaired diastolic function and increased heart failure risk. Animal models and autopsy studies of diabetic patients implicate myocardial fibrosis...

    Authors: Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Casper G Schalkwijk, Mary J Black and Darren J Kelly

    Citation: Cardiovascular Diabetology 2011 10:80

    Content type: Original investigation

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  48. Hypertension is associated with impaired glucose tolerance and insulin resistance. Medical treatment that interferes with various steps in the renin-angiotensin system improves glucose tolerance and insulin re...

    Authors: Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki and Hiroyuki Daida

    Citation: Cardiovascular Diabetology 2011 10:79

    Content type: Original investigation

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