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  1. The relationship between body composition parameters such as thigh and calf circumference and insulin resistance or atherosclerosis in type 2 diabetes is poorly understood. The aim of this study was to investi...

    Authors: Jong Suk Park, Min Ho Cho, Chul Woo Ahn, Kyung Rae Kim and Kap Bum Huh

    Citation: Cardiovascular Diabetology 2012 11:62

    Content type: Original investigation

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  2. Insulin resistance (IR) is the major driving force behind development and progression of atherosclerosis in patients with nonalcoholic fatty liver disease (NAFLD). Therefore, correction of IR is a relevant the...

    Authors: Marina Shargorodsky, Elena Omelchenko, Zipora Matas, Mona Boaz and Dov Gavish

    Citation: Cardiovascular Diabetology 2012 11:61

    Content type: Original investigation

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  3. Diabetic patients present with an accelerated atherosclerotic process and an increased risk for future cardiovascular events. In addition to the risk imposed by the disease itself, pharmacological treatment ad...

    Authors: Robert Klempfner, Jonathan Leor, Alexander Tenenbaum, Enrique Z Fisman and Ilan Goldenberg

    Citation: Cardiovascular Diabetology 2012 11:60

    Content type: Study protocol

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  4. Women with previous gestational diabetes mellitus (pGDM) face a higher risk of developing type 2 diabetes and, consequently, a higher cardiovascular risk. This study aimed to compare the carotid intima-media t...

    Authors: Claudia Maria Vilas Freire, Felipe Batista Lima Barbosa, Maria Cristina C de Almeida, Paulo Augusto Carvalho Miranda, Márcia Melo Barbosa, Anelise Impeliziere Nogueira, Milena Moreira Guimarães, Maria do Carmo Pereira Nunes and Antônio Ribeiro-Oliveira Jr

    Citation: Cardiovascular Diabetology 2012 11:59

    Content type: Original investigation

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  5. Diabetes mellitus is associated with micro- and macrovascular complications and increased cardiovascular risk. Elevated levels of serum asymmetric dimethylarginine (ADMA) may be responsible for endothelial dys...

    Authors: Erik Salum, Priit Kampus, Mihkel Zilmer, Jaan Eha, Mark Butlin, Alberto P Avolio, Taavi Põdramägi, Andres Arend, Marina Aunapuu and Jaak Kals

    Citation: Cardiovascular Diabetology 2012 11:58

    Content type: Original investigation

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  6. Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment...

    Authors: Sabine Fredersdorf, Christian Thumann, Wolfram H Zimmermann, Roland Vetter, Tobias Graf, Andreas Luchner, Günter AJ Riegger, Heribert Schunkert, Thomas Eschenhagen and Joachim Weil

    Citation: Cardiovascular Diabetology 2012 11:57

    Content type: Original investigation

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  7. The prevention of type 2 diabetes is a globally recognised health care priority, but there is a lack of rigorous research investigating optimal methods of translating diabetes prevention programmes, based on t...

    Authors: Laura J Gray, Kamlesh Khunti, Sian Williams, Stephanie Goldby, Jacqui Troughton, Thomas Yates, Alastair Gray and Melanie J Davies

    Citation: Cardiovascular Diabetology 2012 11:56

    Content type: Study protocol

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  8. Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL conc...

    Authors: Dong-Sik Cho, Sookyoung Woo, Seonwoo Kim, Christopher D Byrne, Joon-Hyuk Kong and Ki-Chul Sung

    Citation: Cardiovascular Diabetology 2012 11:55

    Content type: Original investigation

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  9. Uncontrolled blood pressure (BP) is a significant contributor of morbidity and even mortality in type 2 diabetes (T2D) patients. This study was done to determine the significant determinants of uncontrolled bl...

    Authors: Boon How Chew, Ismail Mastura, Sazlina Shariff-Ghazali, Ping Yein Lee, Ai Theng Cheong, Zaiton Ahmad, Sri Wahyu Taher, Jamaiyah Haniff, Feisul Idzwan Mustapha and Mohd Adam Bujang

    Citation: Cardiovascular Diabetology 2012 11:54

    Content type: Original investigation

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  10. Both angiotensin II type I receptor blockers (ARBs) and calcium channel blockers (CCBs) are widely used antihypertensive drugs. Many clinical studies have demonstrated and compared the organ-protection effects...

    Authors: Yayoi Nishida, Yasuo Takahashi, Tomohiro Nakayama and Satoshi Asai

    Citation: Cardiovascular Diabetology 2012 11:53

    Content type: Original investigation

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  11. Admission hyperglycaemia is associated with mortality in patients with acute coronary syndrome (ACS), but controversy exists whether hyperglycaemia uniformly affects both genders. We evaluated coronary risk fa...

    Authors: Julio Yoshio Takada, Rogério Bicudo Ramos, Larissa Cardoso Roza, Solange Desiree Avakian, José Antonio Franchini Ramires and Antonio de Pádua Mansur

    Citation: Cardiovascular Diabetology 2012 11:47

    Content type: Original investigation

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  12. The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitation...

    Authors: Gary Huang, Dan Wang, Unab I Khan, Irfan Zeb, JoAnn E Manson, Virginia Miller, Howard N Hodis, Matthew J Budoff, George R Merriam, Mitchell S Harman, Eliot A Brinton, Marcelle I Cedars, Yali Su, Rogerio A Lobo, Frederick Naftolin, Nanette Santoro…

    Citation: Cardiovascular Diabetology 2012 11:52

    Content type: Original investigation

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  13. Although most deaths among patients with type 2 diabetes (T2D) are attributable to cardiovascular disease, modifiable cardiovascular risk factors appear to be inadequately treated in medical practice. The aim ...

    Authors: Ina-Maria Rückert, Michaela Schunk, Rolf Holle, Sabine Schipf, Henry Völzke, Alexander Kluttig, Karin-Halina Greiser, Klaus Berger, Grit Müller, Ute Ellert, Hannelore Neuhauser, Wolfgang Rathmann, Teresa Tamayo, Susanne Moebus, Silke Andrich and Christa Meisinger

    Citation: Cardiovascular Diabetology 2012 11:50

    Content type: Original investigation

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  14. Chronic elevation of glucose level activates vascular inflammation and increases endothelial adhesiveness to monocytes, an early sign of atherogenesis. This study aimed to elucidate the detailed mechanisms of ...

    Authors: Jia-Shiong Chen, Yung-Hsiang Chen, Po-Hsun Huang, Hsiao-Ya Tsai, Yuh-Lien Chen, Shing-Jong Lin and Jaw-Wen Chen

    Citation: Cardiovascular Diabetology 2012 11:49

    Content type: Original investigation

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  15. Genome-wide association studies (GWAS) are useful to reveal an association between single nucleotide polymorphisms and different measures of obesity. A multitude of new loci has recently been reported, but the...

    Authors: Peter M Schmid, Iris Heid, Christa Buechler, Andreas Steege, Markus Resch, Christoph Birner, Dierk H Endemann, Guenter A Riegger and Andreas Luchner

    Citation: Cardiovascular Diabetology 2012 11:48

    Content type: Original investigation

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  16. Endothelial progenitor cells (EPCs), especially late EPCs, play a critical role in endothelial maintenance and repair, and postnatal vasculogenesis. Advanced glycation end products (AGEs) have been shown to im...

    Authors: Hong Li, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Yuliang Wang, Hairong Chu and Min Cheng

    Citation: Cardiovascular Diabetology 2012 11:46

    Content type: Original investigation

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  17. Metabolic abnormalities have a cumulative effect on development of diabetes, but only central obesity has been defined as the essential criterion of metabolic syndrome (MetS) by the International Diabetes Fede...

    Authors: I-Te Lee, Yen-Feng Chiu, Chii-Min Hwu, Chih-Tsueng He, Fu-Tien Chiang, Yu-Chun Lin, Themistocles Assimes, J David Curb and Wayne H-H Sheu

    Citation: Cardiovascular Diabetology 2012 11:43

    Content type: Original investigation

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  18. Connective tissue growth factor (CTGF) has been implicated in the cardiac and kidney complications of type 2 diabetes, and the CTGF − 945 G/C polymorphism is associated with susceptibility to systemic sclerosis, ...

    Authors: Sheila K Patel, Bryan Wai, Richard J MacIsaac, Sharon Grant, Elena Velkoska, Michelle Ord, Sianna Panagiotopoulos, George Jerums, Piyush M Srivastava and Louise M Burrell

    Citation: Cardiovascular Diabetology 2012 11:42

    Content type: Original investigation

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  19. Uncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). We examined the association of commonly observed UCP2 G(−866)A (rs6593...

    Authors: Sukma Oktavianthi, Hidayat Trimarsanto, Clarissa A Febinia, Ketut Suastika, Made R Saraswati, Pande Dwipayana, Wibowo Arindrarto, Herawati Sudoyo and Safarina G Malik

    Citation: Cardiovascular Diabetology 2012 11:41

    Content type: Original investigation

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  20. Serum C-reactive protein (CRP) and leptin levels have been independently associated with the cardiovascular risk factors. The aim of the present study was to determine if their serum levels were associated wit...

    Authors: Feng-Hsiang Chiu, Chung Hsun Chuang, Wen-Cheng Li, Yi-Ming Weng, Wen-Chih Fann, Hsiang-Yun Lo, Cheng Sun and Shih-Hao Wang

    Citation: Cardiovascular Diabetology 2012 11:40

    Content type: Original investigation

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  21. Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men.

    Authors: Chang-Hee Kwon, Eun-Jung Rhee, Jae-Uk Song, Jung-Tae Kim, Hyon Joo Kwag and Ki-Chul Sung

    Citation: Cardiovascular Diabetology 2012 11:38

    Content type: Original investigation

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  22. The most common apolipoprotein E (apoE) gene polymorphism has been found to influence plasma lipid concentration and its correlation with coronary artery disease (CAD) has been extensively investigated in the ...

    Authors: Rajesh Chaudhary, Atip Likidlilid, Thavatchai Peerapatdit, Damras Tresukosol, Sorachai Srisuma, Suphachai Ratanamaneechat and Charn Sriratanasathavorn

    Citation: Cardiovascular Diabetology 2012 11:36

    Content type: Original investigation

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  23. Health utility (HU) measures are used as overall measures of quality of life and to determine quality adjusted life years (QALYs) in economic analyses. We compared baseline values of three HUs including Short ...

    Authors: Dennis W Raisch, Patricia Feeney, David C Goff Jr, KM Venkat Narayan, Patrick J O’Connor, Ping Zhang, Don G Hire and Mark D Sullivan

    Citation: Cardiovascular Diabetology 2012 11:35

    Content type: Original investigation

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  24. Since betaine is an osmolyte and methyl donor, and abnormal betaine loss is common in diabetes mellitus (>20% patients), we investigated the relationship between betaine and the post-methionine load rise in ho...

    Authors: Michael Lever, Sandy Slow, David O McGregor, Warwick J Dellow, Peter M George and Stephen T Chambers

    Citation: Cardiovascular Diabetology 2012 11:34

    Content type: Original investigation

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  25. A higher increase in intracellular Na+ via Na+/H+ exchanger (NHE) during ischemia has been reported in type 2 diabetic mouse hearts. We investigated the role of NHE in inducing changes in cytoplasmic Ca2+ concent...

    Authors: Ryuko Anzawa, Shingo Seki, Tomohisa Nagoshi, Ikuo Taniguchi, Danielle Feuvray and Michihiro Yoshimura

    Citation: Cardiovascular Diabetology 2012 11:33

    Content type: Original investigation

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  26. Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular (CV) events, comorbid diabetes mellitus, microalbuminuria and renal im...

    Authors: Samir G Mallat

    Citation: Cardiovascular Diabetology 2012 11:32

    Content type: Review

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  27. The metabolic syndrome is associated with increased risk for both diabetes and coronary artery disease, which insulin resistance alone does not satisfactorily explain. We propose an additional and complementar...

    Authors: Surujpal Teelucksingh, Sarada Jaimungal, Lexley Pinto Pereira, Terence Seemungal and Shivananda Nayak

    Citation: Cardiovascular Diabetology 2012 11:31

    Content type: Original investigation

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  28. Indigenous populations of Australia and Canada experience disproportionately high rates of chronic disease. Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recen...

    Authors: Louise J Maple-Brown, Joan Cunningham, Bernard Zinman, Mary Mamakeesick, Stewart B Harris, Philip W Connelly, Jonathan Shaw, Kerin O'Dea and Anthony J Hanley

    Citation: Cardiovascular Diabetology 2012 11:30

    Content type: Original investigation

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  29. The hypoglycemic effect of bezafibrate is well established, but administration to a large population of patients with diabetes has not been reported. We investigated glycemic control, relationship between lipi...

    Authors: Tamio Teramoto, Kohji Shirai, Hiroyuki Daida and Nobuhiro Yamada

    Citation: Cardiovascular Diabetology 2012 11:29

    Content type: Original investigation

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  30. The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, an...

    Authors: Taiga Ichinomiya, Sungsam Cho, Ushio Higashijima, Shuhei Matsumoto, Takuji Maekawa and Koji Sumikawa

    Citation: Cardiovascular Diabetology 2012 11:28

    Content type: Original investigation

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  31. The leading cause of death for patients suffering from diabetes is macrovascular disease. Endothelial dysfunction is often observed in type 2 diabetic patients and it is considered to be an important early eve...

    Authors: Linnéa Eriksson, Özlem Erdogdu, Thomas Nyström, Qimin Zhang and Åke Sjöholm

    Citation: Cardiovascular Diabetology 2012 11:27

    Content type: Original investigation

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  32. Chronic kidney disease (CKD) is associated with cardiovascular events. Adipocyte fatty acid-binding protein (A-FABP) plays an important role in atherosclerosis. We investigated whether plasma A-FABP is involve...

    Authors: Mutsumi Iwamoto, Toru Miyoshi, Masayuki Doi, Ko Takeda, Masahito Kajiya, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi, Kosuke Sakane, Kazuhfumi Nakamura and Hiroshi Ito

    Citation: Cardiovascular Diabetology 2012 11:26

    Content type: Original investigation

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  33. People with central obesity have an increased risk for developing the metabolic syndrome, type 2 diabetes and cardiovascular disease. However, a substantial part of obese individuals have no other cardiovascul...

    Authors: Corine den Engelsen, Paula S Koekkoek, Kees J Gorter, Maureen van den Donk, Philippe L Salomé and Guy E Rutten

    Citation: Cardiovascular Diabetology 2012 11:25

    Content type: Original investigation

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  34. Cardiac autonomic neuropathy (CAN) is a common complication of diabetes associated with poor prognosis. In addition, the autonomic imbalance is associated with cardiovascular disease (CVD) in diabetes. It is t...

    Authors: Chan-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Sang-Hee Jung and Ji-Oh Mok

    Citation: Cardiovascular Diabetology 2012 11:24

    Content type: Original investigation

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  35. Premature ventricular complexes (PVC) predict cardiovascular mortality among several adult populations. Increased arrhythmia prevalence has been reported during controlled magnesium (Mg) depletion studies in a...

    Authors: Liana C Del Gobbo, Yiqing Song, Paul Poirier, Eric Dewailly, Ronald J Elin and Grace M Egeland

    Citation: Cardiovascular Diabetology 2012 11:23

    Content type: Original investigation

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  36. B-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Intraabdominal fat accumulation is ...

    Authors: Hideaki Nakatsuji, Ken Kishida, Tohru Funahashi, Tohru Nakagawa and Iichiro Shimomura

    Citation: Cardiovascular Diabetology 2012 11:22

    Content type: Original investigation

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  37. Meta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease (CAD). Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by ...

    Authors: Chih-Sheng Chu, Kun-Tai Lee, Kai-Hong Cheng, Min-Yi Lee, Hsuan-Fu Kuo, Tsung-Hsien Lin, Ho-Ming Su, Wen-Chol Voon, Sheng-Hsiung Sheu and Wen-Ter Lai

    Citation: Cardiovascular Diabetology 2012 11:21

    Content type: Original investigation

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  38. Visceral adiposity index (VAI) has recently been suggested to be used as a surrogate of visceral adiposity. We examined if VAI could improve predictive performances for CVD of the Framingham's general CVD algo...

    Authors: Bozorgmanesh Mohammadreza, Hadaegh Farzad, Khalili Davoud and Azizi Fereidoun Prof

    Citation: Cardiovascular Diabetology 2012 11:20

    Content type: Original investigation

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  39. Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predic...

    Authors: Henrik Reinhard, Peter R Hansen, Niels Wiinberg, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Peter Rossing and Peter K Jacobsen

    Citation: Cardiovascular Diabetology 2012 11:19

    Content type: Original investigation

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  40. Lower extremity amputations are costly and debilitating complications in patients with diabetes mellitus (DM). Our aim was to investigate changes in the amputation rate in patients with DM at the Karolinska Un...

    Authors: Alexandra Alvarsson, Buster Sandgren, Carl Wendel, Michael Alvarsson and Kerstin Brismar

    Citation: Cardiovascular Diabetology 2012 11:18

    Content type: Original investigation

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  41. The purpose of this study was to assess the efficacy of interventional therapy for peripheral arterial occlusive disease and the difference between diabetic patients and non-diabetic patients.

    Authors: Liang Xiao, De-sheng Huang, Jia-jie Tong and Jing Shen

    Citation: Cardiovascular Diabetology 2012 11:17

    Content type: Original investigation

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  42. People of different racial and ethnic backgrounds have a distinct pattern of central fat deposition, thus making it necessary to devise a race based approach for the diagnosis and evaluation of abdominal obesi...

    Authors: Aibek E Mirrakhimov, Olga S Lunegova, Alina S Kerimkulova, Cholpon B Moldokeeva, Malik P Nabiev and Erkin M Mirrakhimov

    Citation: Cardiovascular Diabetology 2012 11:16

    Content type: Original investigation

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  43. Generalized arterial alterations, such as endothelial dysfunction, medial matrix accumulations, and calcifications are associated with type 2 diabetes (T2D). These changes may render the vessel wall more susce...

    Authors: Vibe Skov, Steen Knudsen, Malene Olesen, Maria L Hansen and Lars M Rasmussen

    Citation: Cardiovascular Diabetology 2012 11:15

    Content type: Original investigation

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  44. The prognostic benefits of beta-blockers (BB) in patients with systolic heart failure (SHF) are known but despite this, in patients with diabetes they are underutilized. The aim of this study was to assess the...

    Authors: Bryan Wai, Leighton G Kearney, David L Hare, Michelle Ord, Louise M Burrell and Piyush M Srivastava

    Citation: Cardiovascular Diabetology 2012 11:14

    Content type: Original investigation

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  45. The aim of this study is to investigate the relationships between HbA1c and other risk factors like obesity, functional fitness, lipid profile, and inflammatory status in older adults. Epidemiological evidence...

    Authors: Raul A Martins, John G Jones, Sean P Cumming, Manuel J Coelho e Silva, Ana M Teixeira and Manuel T Veríssimo

    Citation: Cardiovascular Diabetology 2012 11:13

    Content type: Original investigation

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  46. The decrease and dysfunction of endothelial progenitor cells (EPCs) has been assumed as an important cause/consequence of diabetes mellitus (DM) and its complications, in which the senescence of EPCs induced b...

    Authors: Zhiyong Yin, Linni Fan, Gaosheng Huang, Haichang Wang and Zhe Wang

    Citation: Cardiovascular Diabetology 2012 11:12

    Content type: Hypothesis

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  47. Lipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a la...

    Authors: Ying Huang, Zhen Yang, Zi Ye, Qin Li, Jie Wen, Xiaoming Tao, Lili Chen, Min He, Xuanchun Wang, Bin Lu, Zhaoyun Zhang, Weiwei Zhang, Shen Qu and Renming Hu

    Citation: Cardiovascular Diabetology 2012 11:11

    Content type: Original investigation

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