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  1. Patients with the metabolic syndrome are more likely to develop type 2 diabetes and may have an increased risk of cardiovascular disease (CVD) events.We aimed to establish whether CVD event rates were influenc...

    Authors: Russell Scott, Mark Donoghoe, Gerald F Watts, Richard O'Brien, Christopher Pardy, Marja-Riitta Taskinen, Timothy ME Davis, Peter G Colman, Patrick Manning, Gregory Fulcher and Anthony C Keech

    Citation: Cardiovascular Diabetology 2011 10:102

    Content type: Original investigation

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  2. Soluble ST2, a member of the of the Toll/IL-1 superfamily, is a novel biomarker with exceptional predictive value in heart failure and myocardial infarction- related mortality as well as in acute dyspneic stat...

    Authors: Evangelos Fousteris, Andreas Melidonis, George Panoutsopoulos, Konstantinos Tzirogiannis, Stefanos Foussas, Anastasios Theodosis-Georgilas, Stavros Tzerefos, Spiridon Matsagos, Eleni Boutati, Theofanis Economopoulos, George Dimitriadis and Sotirios Raptis

    Citation: Cardiovascular Diabetology 2011 10:101

    Content type: Original investigation

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  3. Insulin resistance is accompanied by a cluster of metabolic changes, often referred to as metabolic syndrome. Metabolic syndrome is associated with an increased cardiovascular risk in patients with manifest ar...

    Authors: Sandra N Verhagen, Annemarie MJ Wassink, Yolanda van der Graaf, Petra M Gorter and Frank LJ Visseren

    Citation: Cardiovascular Diabetology 2011 10:100

    Content type: Original investigation

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  4. Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcif...

    Authors: Melissa Simpson, Janet K Snell-Bergeon, Gregory L Kinney, Orit Lache, Rachel Miller-Lotan, Yefim Anbinder, Marian J Rewers and Andrew P Levy

    Citation: Cardiovascular Diabetology 2011 10:99

    Content type: Original investigation

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  5. The prognostic value of hemoglobin A1c (HbA1c) in coronary artery disease (CAD) remains controversial. Herein, we conducted a systematic review to quantify the association between elevated HbA1c levels and all...

    Authors: Yao Liu, Yan-min Yang, Jun Zhu, Hui-qiong Tan, Yan Liang and Jian-dong Li

    Citation: Cardiovascular Diabetology 2011 10:98

    Content type: Original investigation

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  6. Numerous evidences suggest that diabetic heart is characterized by compromised ventricular contraction and prolonged relaxation attributable to multiple causative factors including calcium accumulation, oxidat...

    Authors: Vasundhara Kain, Sandeep Kumar and Sandhya L Sitasawad

    Citation: Cardiovascular Diabetology 2011 10:97

    Content type: Original investigation

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  7. Both genetic and environmental factors play a role in the pathogenesis of type 2 diabetes and cardiovascular diseases. The magnitude of genetic and environmental influences may vary in different populations an...

    Authors: György Jermendy, Tamás Horváth, Levente Littvay, Rita Steinbach, Ádám L Jermendy, Ádám D Tárnoki, Dávid L Tárnoki, Júlia Métneki and János Osztovits

    Citation: Cardiovascular Diabetology 2011 10:96

    Content type: Original investigation

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  8. Diabetes mellitus and renal dysfunction are prognostic factors after acute myocardial infarction (AMI). However, few studies have assessed the effects of renal insufficiency in association with diabetes in the...

    Authors: Chang Seong Kim, Joon Seok Choi, Jeong Woo Park, Eun Hui Bae, Seong Kwon Ma, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim and Soo Wan Kim

    Citation: Cardiovascular Diabetology 2011 10:95

    Content type: Original investigation

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  9. Aldosterone levels are elevated in a rat model of type 2 diabetes mellitus, the Zucker Diabetic fatty rat (ZDF). Moreover blood pressure in ZDF rats is salt-sensitive. The aim of this study was to examine the ...

    Authors: Markus Resch, Peter Schmid, Kerstin Amann, Sabine Fredersdorf, Joachim Weil, Christian Schach, Christoph Birner, Daniel P Griese, Peter Kreuzer, Sabine Brunner, Andreas Luchner, Günter AJ Riegger and Dierk H Endemann

    Citation: Cardiovascular Diabetology 2011 10:94

    Content type: Original investigation

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  10. The triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been advocated as a simple clinical indicator of insulin resistance. Thresholds of TG/HDL-C appeared to depend on ethnicity. Howeve...

    Authors: Jui-Kun Chiang, Ning-Sheng Lai, Jiunn-Kae Chang and Malcolm Koo

    Citation: Cardiovascular Diabetology 2011 10:93

    Content type: Original investigation

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  11. Diabetic cardiomyopathy (CMP) is a common and disabling disease in diabetic patients, however no effective treatments have been developed. Although granulocyte-colony stimulating factor (G-CSF) improves heart ...

    Authors: Young-Hyo Lim, Jun-Ho Joe, Ki-Seok Jang, Yi-Sun Song, Byung-Im So, Cheng-Hu Fang, Jinho Shin, Jung-Hyun Kim, Heon-Kil Lim and Kyung-Soo Kim

    Citation: Cardiovascular Diabetology 2011 10:92

    Content type: Original investigation

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  12. Carvedilol has been shown to be superior to metoprolol tartrate to improve clinical outcomes in patients with heart failure (HF), yet the mechanisms responsible for these differences remain unclear. We examine...

    Authors: Britt Falskov, Thomas Steffen Hermann, Jakob Raunsø, Buris Christiansen, Christian Rask-Madsen, Atheline Major-Pedersen, Lars Køber, Christian Torp-Pedersen and Helena Dominguez

    Citation: Cardiovascular Diabetology 2011 10:91

    Content type: Original investigation

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  13. Cardiovascular disease morbidity-mortality is greater in people with type 2 diabetes mellitus or metabolic syndrome. The purpose of this study was to evaluate the yearly evolution of organ damage markers in di...

    Authors: Manuel A Gomez-Marcos, Jose I Recio-Rodríguez, Maria C Patino-Alonso, Cristina Agudo-Conde, Leticia Gomez-Sanchez, Emiliano Rodriguez-Sanchez, Marta Gomez-Sanchez and Luis Garcia-Ortiz

    Citation: Cardiovascular Diabetology 2011 10:90

    Content type: Original investigation

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  14. B3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic ab...

    Authors: Aibek E Mirrakhimov, Alina S Kerimkulova, Olga S Lunegova, Cholpon B Moldokeeva, Yulia V Zalesskaya, Samai S Abilova, Nurmira A Sovhozova, Almaz A Aldashev and Erkin M Mirrakhimov

    Citation: Cardiovascular Diabetology 2011 10:89

    Content type: Original investigation

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  15. Carotid intima-media thickness (IMT), indices of large artery stiffness and measures of endothelium function may be used as markers of early atherosclerosis in type 1 diabetes mellitus (T1DM). The aim of the p...

    Authors: Carlo Palombo, Michaela Kozakova, Carmela Morizzo, Laura Gnesi, Maria Chiara Barsotti, Paolo Spontoni, Francesco Massart, Paolo Salvi, Alberto Balbarini, Giuseppe Saggese, Rossella Di Stefano and Giovanni Federico

    Citation: Cardiovascular Diabetology 2011 10:88

    Content type: Original investigation

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  16. Growing evidence suggests that epicardial adipose tissue (EAT) may play a key role in the pathogenesis and development of coronary artery disease (CAD) by producing several inflammatory adipokines. Chemerin, a...

    Authors: Xiuying Gao, Shuhua Mi, Fuzhuang Zhang, Fengying Gong, Yongqiang Lai, Feng Gao, Xiaoxia Zhang, Linjie Wang and Hong Tao

    Citation: Cardiovascular Diabetology 2011 10:87

    Content type: Original investigation

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  17. We analyzed the effects of insulin therapy, age and gender on the risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) according to glycemic control.

    Authors: Toshio Hayashi, Seinosuke Kawashima, Hideki Nomura, Hideki Itoh, Hiroshi Watanabe, Takashi Ohrui, Koutaro Yokote, Hirohito Sone, Yoshiyuki Hattori, Masao Yoshizumi, Koichiro Ina and Kiyoshi Kubota

    Citation: Cardiovascular Diabetology 2011 10:86

    Content type: Original investigation

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  18. Progressive remodeling after myocardial infarction (MI) is a leading cause of morbidity and mortality. Recently, glucagon-like peptide (GLP)-1 was shown to have cardioprotective effects, but treatment with GLP...

    Authors: Meimei Yin, Herman HW Silljé, Maxi Meissner, Wiek H van Gilst and Rudolf A de Boer

    Citation: Cardiovascular Diabetology 2011 10:85

    Content type: Original investigation

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  19. Obstructive sleep apnea (OSA) is a common yet underdiagnosed condition. The aim of our study is to test whether prediabetes and type 2 diabetes are associated with obstructive sleep apnea (OSA) in extremely ob...

    Authors: Jan Magnus Fredheim, Jan Rollheim, Torbjørn Omland, Dag Hofsø, Jo Røislien, Kristian Vegsgaard and Jøran Hjelmesæth

    Citation: Cardiovascular Diabetology 2011 10:84

    Content type: Original investigation

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  20. Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized that mediate effects of adiponectin in various tis...

    Authors: Niina Siitonen, Leena Pulkkinen, Jaana Lindström, Marjukka Kolehmainen, Ursula Schwab, Johan G Eriksson, Pirjo Ilanne-Parikka, Sirkka Keinänen-Kiukaanniemi, Jaakko Tuomilehto and Matti Uusitupa

    Citation: Cardiovascular Diabetology 2011 10:83

    Content type: Original investigation

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  21. To investigate the effect of physician- and patient-specific feedback with benchmarking on the quality of care in adults with type 2 diabetes mellitus (T2DM).

    Authors: Frank Nobels, Noëmi Debacker, Carlos Brotons, Moses Elisaf, Michel P Hermans, Georges Michel and Erik Muls

    Citation: Cardiovascular Diabetology 2011 10:82

    Content type: Methodology

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  22. Metabolic syndrome (MS) is a clustering of cardiometabolic risk factors that is considered a predictor of cardiovascular disease, type 2 diabetes and mortality. There is no consistent evidence on whether the M...

    Authors: Vicente Martínez-Vizcaino, Francisco B Ortega, Montserrat Solera-Martínez, Jonatan R Ruiz, Idoia Labayen, Diva Eensoo, Jaanus Harro, Helle-Mai Loit, Toomas Veidebaum and Michael Sjöström

    Citation: Cardiovascular Diabetology 2011 10:81

    Content type: Original investigation

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  23. Type 2 diabetes and the metabolic syndrome are associated with impaired diastolic function and increased heart failure risk. Animal models and autopsy studies of diabetic patients implicate myocardial fibrosis...

    Authors: Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Casper G Schalkwijk, Mary J Black and Darren J Kelly

    Citation: Cardiovascular Diabetology 2011 10:80

    Content type: Original investigation

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  24. Hypertension is associated with impaired glucose tolerance and insulin resistance. Medical treatment that interferes with various steps in the renin-angiotensin system improves glucose tolerance and insulin re...

    Authors: Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki and Hiroyuki Daida

    Citation: Cardiovascular Diabetology 2011 10:79

    Content type: Original investigation

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  25. Cinnamon has been shown to delay gastric emptying of a high-carbohydrate meal and reduce postprandial glycemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associate...

    Authors: Oonagh Markey, Conor M McClean, Paul Medlow, Gareth W Davison, Tom R Trinick, Ellie Duly and Amir Shafat

    Citation: Cardiovascular Diabetology 2011 10:78

    Content type: Original investigation

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  26. Cardiovascular disease (CVD) is frequent in type 2 diabetes mellitus patients due to accelerated atherosclerosis. Plasma osteoprotegerin (OPG) has evolved as a biomarker for CVD. We examined the relationship b...

    Authors: Mikael K Poulsen, Mads Nybo, Jordi Dahl, Susanne Hosbond, Tina S Poulsen, Allan Johansen, Poul F Høilund-Carlsen, Henning Beck-Nielsen, Lars M Rasmussen and Jan E Henriksen

    Citation: Cardiovascular Diabetology 2011 10:76

    Content type: Original investigation

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  27. Diabetes mellitus is strongly associated with cardiovascular dysfunction, derived in part from impairment of sympathetic nervous system signaling. Glucose, insulin, and non-esterified fatty acids are potent st...

    Authors: James T Thackeray, Jerry Radziuk, Mary-Ellen Harper, Erik J Suuronen, Kathryn J Ascah, Rob S Beanlands and Jean N DaSilva

    Citation: Cardiovascular Diabetology 2011 10:75

    Content type: Original investigation

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  28. Angiotensin II receptor blockers (ARBs), including olmesartan and candesartan, are widely used antihypertensive agents. Many clinical studies have demonstrated that ARBs have organ-protecting effects, e.g., ca...

    Authors: Yayoi Nishida, Yasuo Takahashi, Tomohiro Nakayama, Masayoshi Soma and Satoshi Asai

    Citation: Cardiovascular Diabetology 2011 10:74

    Content type: Original investigation

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  29. High glucose can induce apoptosis in vascular endothelial cells, which may contribute to the development of vascular complications in diabetes. We evaluated the role of the death receptor pathway of apoptotic ...

    Authors: Shun-ichiro Kageyama, Hiroki Yokoo, Kengo Tomita, Natsuko Kageyama-Yahara, Ryo Uchimido, Naoyuki Matsuda, Seiji Yamamoto and Yuichi Hattori

    Citation: Cardiovascular Diabetology 2011 10:73

    Content type: Original investigation

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  30. We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes.

    Authors: Qin Li, Zhen Yang, Bin Lu, Jie Wen, Zi Ye, Lili Chen, Min He, Xiaoming Tao, Weiwei Zhang, Ying Huang, Zhaoyun Zhang, Shen Qu and Renming Hu

    Citation: Cardiovascular Diabetology 2011 10:72

    Content type: Original investigation

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  31. Intensive multifactorial treatment aimed at cardiovascular (CV) risk factor reduction in type 2 diabetic patients with microalbuminuria can diminish fatal and non-fatal CV. Plasma N-terminal (NT)-proBNP predic...

    Authors: Henrik Reinhard, Niels Wiinberg, Peter R Hansen, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Peter Rossing and Peter K Jacobsen

    Citation: Cardiovascular Diabetology 2011 10:71

    Content type: Original investigation

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  32. Plasma osteoprotegerin (P-OPG) is an independent predictor of cardiovascular disease in diabetic and other populations. OPG is a bone-related glycopeptide produced by vascular smooth muscle cells and increased...

    Authors: Henrik Reinhard, Mads Nybo, Peter R Hansen, Niels Wiinberg, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Lars M Rasmussen, Peter Rossing and Peter K Jacobsen

    Citation: Cardiovascular Diabetology 2011 10:70

    Content type: Original investigation

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  33. Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes, which is characterized by both systolic and diastolic dysfunction. The effective treatment strategy for DCM has not been...

    Authors: Bingong Li, Zeqi Zheng, Yunfeng Wei, Menghong Wang, Jingtian Peng, Ting Kang, Xin Huang, Jian Xiao, Yong Li and Zhe Li

    Citation: Cardiovascular Diabetology 2011 10:69

    Content type: Original investigation

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  34. High fat diet impairs nitric oxide (NO) bioavailability, and induces insulin resistance. The link between NO availability and the metabolic adaptation to a high fat diet is not well characterized. The purpose ...

    Authors: Urszula Razny, Beata Kiec-Wilk, Lukasz Wator, Anna Polus, Grzegorz Dyduch, Bogdan Solnica, Maciej Malecki, Romana Tomaszewska, John P Cooke and Aldona Dembinska-Kiec

    Citation: Cardiovascular Diabetology 2011 10:68

    Content type: Original investigation

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  35. Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, is linked to cardiovascular disease. Negative associations exist between circulating OPG and cardiac function. The adi...

    Authors: Weena JY Chen, Luuk J Rijzewijk, Rutger W van der Meer, Martijn W Heymans, Eelco van Duinkerken, Mark Lubberink, Adriaan A Lammertsma, Hildo J Lamb, Albert de Roos, Johannes A Romijn, Jan WA Smit, Jeroen J Bax, Mette Bjerre, Jan Frystyk, Allan Flyvbjerg and Michaela Diamant

    Citation: Cardiovascular Diabetology 2011 10:67

    Content type: Original investigation

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  36. We aimed to identify predictors of anamnestic hypoglycaemia in type-2 diabetic patients on oral mono- or dual oral combination antidiabetic pharmacotherapy.

    Authors: Diethelm Tschöpe, Peter Bramlage, Christiane Binz, Michael Krekler, Tanja Plate, Evelin Deeg and Anselm K Gitt

    Citation: Cardiovascular Diabetology 2011 10:66

    Content type: Original investigation

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  37. We analyzed specific effects of an add-on therapy with pioglitazone compared to metformin and their combination in patients with basal insulin treatment on biomarkers of CV risk.

    Authors: Markolf Hanefeld, Andreas Pfützner, Thomas Forst, Iris Kleine and Winfried Fuchs

    Citation: Cardiovascular Diabetology 2011 10:65

    Content type: Original investigation

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  38. Diabetes is thought to accelerate cardiovascular disease depending on the type of diet. This study in diabetic subjects was performed to investigate the metabolic, inflammatory and cardiovascular effects of nu...

    Authors: Sietse J Koopmans, Ruud Dekker, Mariette T Ackermans, Hans P Sauerwein, Mireille J Serlie, Heleen MM van Beusekom, Mieke van den Heuvel and Wim J van der Giessen

    Citation: Cardiovascular Diabetology 2011 10:64

    Content type: Original investigation

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  39. Diabetes mellitus (DM) is a well-established risk factor for perioperative cardiovascular morbidity and mortality in patients undergoing noncardiac surgery. However, the impact of preoperative glucose levels o...

    Authors: Murat Biteker, Akin Dayan, Mehmet M Can, Erkan İlhan, Funda S Biteker, Ahmet Tekkeşin and Dursun Duman

    Citation: Cardiovascular Diabetology 2011 10:63

    Content type: Original investigation

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  40. Cardiovascular diseases (CVD) in diabetic patients have endothelial dysfunction as a key pathogenetic event. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), plays a ...

    Authors: Giovanni Li Volti, Salvatore Salomone, Valeria Sorrenti, Andrea Mangiameli, Vincenzo Urso, Ilias Siarkos, Fabio Galvano and Federico Salamone

    Citation: Cardiovascular Diabetology 2011 10:62

    Content type: Original investigation

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  41. South Asians have a high burden of type 2 diabetes and vascular complications. Vascular inflammation is considered central in the pathophysiology of atherosclerosis, and the complement system is thought to pla...

    Authors: Machiel A Siezenga, Prataap K Chandie Shaw, Mohamed R Daha, Ton J Rabelink and Stefan P Berger

    Citation: Cardiovascular Diabetology 2011 10:60

    Content type: Original investigation

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  42. Lack of suitable mouse models has hindered the studying of diabetic macrovascular complications. We examined the effects of type 2 diabetes on coronary artery disease and cardiac function in hypercholesterolem...

    Authors: Suvi E Heinonen, Mari Merentie, Marja Hedman, Petri I Mäkinen, Elina Loponen, Ivana Kholová, Fatima Bosch, Markku Laakso and Seppo Ylä-Herttuala

    Citation: Cardiovascular Diabetology 2011 10:59

    Content type: Original investigation

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  43. Although the ADA/EASD/IDF International Expert Committee recommends using hemoglobin A1c (HbA1c) to define diabetes, the relation between HbA1c and cardiovascular disease (CVD) has not been thoroughly investig...

    Authors: Rimei Nishimura, Tomoko Nakagami, Hirohito Sone, Yasuo Ohashi and Naoko Tajima

    Citation: Cardiovascular Diabetology 2011 10:58

    Content type: Original investigation

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  44. Diabetic cardiomyopathy, a diabetes-specific complication, refers to a disorder that eventually leads to left ventricular hypertrophy in addition to diastolic and systolic dysfunction. In recent studies, hyper...

    Authors: Po-Ming Ku, Li-Jen Chen, Jia-ru Liang, Kai-Chun Cheng, Yin-Xiao Li and Juei-Tang Cheng

    Citation: Cardiovascular Diabetology 2011 10:57

    Content type: Original investigation

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  45. Diabetes mellitus type 2 (DM2) is a risk factor for coronary heart disease (CHD). While there is a clear correlation of fasting blood glucose (FBG) and 2 h post-challenge blood glucose values (2h-BG) with micr...

    Authors: Sven Schinner, Reiner Füth, Kerstin Kempf, Stephan Martin, Holger S Willenberg, Matthias Schott, Wilfried Dinh, Werner A Scherbaum and Mark Lankisch

    Citation: Cardiovascular Diabetology 2011 10:56

    Content type: Original investigation

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  46. Type 2 diabetes is associated with increased levels of Angiopoietin-2 (Ang-2) and soluble Tie-2 (sTie-2), but its impact on vascular disease is still unknown. This study aimed to further explore the associatio...

    Authors: Sazan Rasul, Marie Helene Reiter, Aysegul Ilhan, Katharina Lampichler, Ludwig Wagner and Alexandra Kautzky-Willer

    Citation: Cardiovascular Diabetology 2011 10:55

    Content type: Original investigation

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  47. Type 1 diabetes mellitus is a generally accepted atherogenic risk factor. The aim of this prospective longitudinal study was to evaluate changes in carotid intima media thickness (cIMT) in children and adolesc...

    Authors: Robert Dalla Pozza, Andreas Beyerlein, Claude Thilmany, Claudia Weissenbacher, Heinrich Netz, Heinrich Schmidt and Susanne Bechtold

    Citation: Cardiovascular Diabetology 2011 10:53

    Content type: Original investigation

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